Human Endocrine Physiology February 27, 2014.

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Presentation transcript:

Human Endocrine Physiology February 27, 2014

Sex Determination and Differentiation

SRY

AMH T

SRY Gene

Testicular Steroid Pathways Progesterone Pregnenolone Cholesterol 17OH-Prog 17OH-Preg T A4 LH/FSH

Conversion of Testosterone to Dihydrotestosterone

SRY AMH T

Conversion of Testosterone to Dihydrotestosterone

Adrenal Steroid Pathways Progesterone Pregnenolone Cholesterol Cortisol 17OH-Prog 17OH-PregDHEA Testosterone Androstenedione Aldosterone ACTH

Classical Congenital Adrenal Hyperplasia Progesterone Pregnenolone Cholesterol Cortisol 17OH-Prog 17OH-PregDHEA Testosterone Androstenedione Aldosterone ACTH * *21-hydroxylase loss of function mutation *

Classical Congenital Adrenal Hyperplasia Progesterone Pregnenolone Cholesterol Cortisol 17OH-Prog 17OH-Preg DHEA Testosterone Androstenedione Aldosterone ACTH * *21-hydroxylase loss of function mutation *

Human Endocrine Physiology: The Menstrual Cycle

Ovarian Physiology GnRH Pituitary Ovary LH FSH Inhibin Estrogens Progesterone Androgens

FSH Sex steroid Inhibin* + Gonadotropin Releasing Hormone (GnRH) + (pituitary) (hypothalamus) (ovary) LH - (+) *Inhibin exerts negative feedback only at the pituitary and only on FSH

Insulin

Ovarian Steroid Pathways Progesterone Pregnenolone Cholesterol 17OH-Prog 17OH-Preg T A4 LH/FSH Estrone Estradiol

*Only enzyme to know **

Changes in Hormones Across the Menstrual Cycle 0 Ov30 FSH

Changes in Hormones Across the Menstrual Cycle 0 Ov30 Estradiol

Changes in Hormones Across the Menstrual Cycle 0 Ov30 LH

Changes in Hormones Across the Menstrual Cycle 0 Ov30 Progesterone

Inhibin * * *LH receptors on granulosa cells induced by FSH

Changes in Hormones Across the Menstrual Cycle 0 Ov30 Inhibin

* * *LH receptors on granulosa cells induced by FSH

Functions of FSH During the Menstrual Cycle

Functions of LH During the Menstrual Cycle

Functions of Estradiol During the Menstrual Cycle

Functions of Progesterone During the Menstrual Cycle

Functions of Inhibin During the Menstrual Cycle

Changes in Hormones Across the Menstrual Cycle 0 Ov30