1 One-Minute NMR History Current Events 17 August 2006 Presented by Tim Peck & Dean Olson

2 e-Seminar Etiquette Press *6 to mute Press #6 to un-mute (to ask a question) As a courtesy to others, please mute your phone line while listening:

3 One-Minute NMR historical roots UIUC Campus Paul Lauterbur: MRI Herb Gutowski Memorial

4 One-Minute NMR 2006 tour Am. Soc. of Pharmacognosy: Arlington, VA 8/6 – 8/9 ENC: Monterey, CA 4/24 – 4/28

5 MicroFlow NMR The NMR Front End for the Modern Analytical Laboratory

6 Live Participation Enter Your Sample Info

7 System Operation Watch the Analysis!

8 NMR Data Collected Pre-Conference Varian Inova 600 MHz

9 View the Results! Automated Structure Confirmation Click … Thumbs Up! (Confirmation) Thumbs Down! (Rejection)

10 View the Results! Automated Structure Confirmation Integrated ACD/Web Librarian

11 Am. Soc. Pharmacognosy August 6-9, 2006

12 Natural Products Chemical AssignmentRapid Dereplication M. Gronquist, J. Meinwald, F. C. Schroeder, JACS 2005, 127, pp dqf-COSY HMQC HMBC NOESY S. Van der Sar, J. Blunt, and M. Munro, Org. Let. 2006, 8(10), pp

13 Some time for fun…

14 And re-connecting with old friends

15 How Small is 10 μL?

16 Autosampler Injection Port

17 Autosampler Needle on a 96-Well Microtitre Plate

18 Needle at Wash Station

19 Autosampler Control Pad

20 Solvent Conditioner Bottles

21 Solvent Conditioner

22 One-Minute NMR Features Sample Return Sample Return Stacked Sample Drawers

23 One-Minute NMR System Configuration

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25 Quiz Question: What is this?

26 Hint: Am. Soc. Pharmacognosy Dinner Cruise was down the Potomac river