1/7/15 Starter: What affect do mutations have on proteins? 1/7/15 Mutations and Pedigrees Application: Ws Connection/Exit: Your cousin has hemophilia but no one else in your immediate family does. How could you go about finding where he/she got this disease? Practice: Explain Non-disjunction

January 7, 2015 AGENDA B.6 E Students will Identify and illustrate changes in DNA and evaluate the significance of these changes. by reading and writing during an activity. 1 Starter 2. Activity

Date Lecture/ Activity/ Lab Page 11/20 DNA Model /21 DNA Writing /1 DNA Replication Activity /2 DNA Replication Model /3 Cell Cycle Notes /4 Cell Cycle Lab /5 Cell Cycle Writing /8 Cell Cycle Activity /10 RNA Notes /11 Transcription and Translation /15 Protein Synthesis Simulation /16 Mutations /17 Mutations /7 Mutations and Pedigrees Table of Contents 11/19 DNA notes 97-98

Changes in DNA

Non-Disjunction Ex: Trisomy 21 or Down Syndrome Sometimes, there is an error in meiosis when egg or sperm cells divide resulting in too many or too few chromosomes. How do you think this type of change would impact an organism? Causes an abnormal number of chromosomes and often results in genetic disorders (ex. Down Syndrome, Turner’s Syndrome, Triple-X Syndrome). This can also result in death of the fetus. karyotype

Mutation Impact The impact of a mutation on an individual also depends on where and when it occurs. If there was a mutation in the DNA of a zygote, how would that impact the individual? How might a mutation in a skin cell affect an individual?

Pedigree Charts Pedigree charts are like a genetic family tree. They can use family information to trace genetic conditions that have been passed along in the family (genetic conditions caused by mutations). Genetic counselors use them to help people analyze their family history and determine the probability of them having or passing on a particular condition (mutation).

Pedigree Chart Symbols Empty Square = male Empty Circle = female Filled/Darkened Square = affected male Filled/Darkened Circle = affected female Square/Circle with Slash through = deceased individual

Pedigree Chart Example

12/11/13 Starter: What is a “silent” point mutation, and what impact does it have on a point? What is an example? 12/11/ Mutations and Pedigrees Application: Ws Connection/Exit: Your cousin has hemophilia but no one else in your immediate family does. How could you go about finding where he/she got this disease? Practice: Notes