Protein Microspheres for Stimulating Bone Regeneration A. Scruggs, G. Farrar and A. W. Morgan Summer Objectives 1. Synthesize albumin microspheres for.

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Protein Microspheres for Stimulating Bone Regeneration A. Scruggs, G. Farrar and A. W. Morgan Summer Objectives 1. Synthesize albumin microspheres for enhancing bone marrow regeneration 2. Crosslink the protein with a reducing sugar such as ribose 3. Identify an enzyme to enable controlled degradation of the microspheres to release the protein NSF-Virginia Tech-REU DMR on Field-Responsive Materials: 2008 Research Highlight Akia Scruggs Rising senior in Chemistry Norfolk State University GPA: 3.2 Hometown: Columbus, OH Akia Scruggs Rising senior in Chemistry Norfolk State University GPA: 3.2 Hometown: Columbus, OH Protein microspheres prepared in a water-in-oil emulsion

Middle Schoolers in VT’s NSF Summer Science Program, mentored by REU students, conduct science experiments and prepare their demonstration projects NSF-Virginia Tech-REU DMR Field-Responsive Materials and Young Scientist Experience

NSF-Virginia Tech-REU DMR Field-Responsive Materials 2008 Field-Responsive Materials Summer undergraduates Middle School Young Scientists Virginia Tech’s materials’ REU features mentored research, education in communications and scientific ethics, an introductory short course on polymers, team-building skills, picnics, a talent show, an end-of summer symposium and science and engineering projects with Middle Schoolers.

Well-defined Amphiphilic Polymer-coated Magnetite Nanoparticles Judy S. Riffle (Virginia Tech), DMR , in collaboration with Richey M. Davis, (Virginia Tech) Fe 3 O 4 Dynamic structures In a hydrophobic lipid membrane In hydrophilic media The diameters of the amphiphilic nanoparticles can be estimated from DLVO theory combined with experimental magnetite sizes from TEM. Then colloidal stability in water can be predicted from the half-lives for doublet formation. Long t 1/2 values correspond to predictions of long-standing colloidal stability. Select examples of these complexes are sufficiently hydrophilic to maintain colloid stability in water, yet sufficiently hydrophobic to interact with hydrophobic areas in cell membranes.

We have synthesized a systematic series of polymer-magnetite nanoparticles to determine how molecular parameters of polymeric amphiphilic coatings affect interactions with select cell membranes. Magnetite nanoparticles coated with a poly(propylene oxide-b-ethylene oxide) diblock copolymer (block MWs of 3300 g/mole PPO and 2600 g/mole PEO) inhibit the drug resistance that develops in cancer cells, likely by interacting with membrane-bound proteins via the hydrophobic copolymer block. Rhodamine accumulation in the cells mimics how chemotherapy drugs can enter cancer cells. Thus, high dye accumulation in the cells indicates that the multi-drug resistance P- glycoprotein pump has been partially inactivated. Amphiphilic Polymer-coated Magnetite Nanoparticles Interact with Cancer Cell Membranes Judy S. Riffle (Virginia Tech), DMR , in collaboration with Alexander V. Kabanov and Tatiana Bronich (University of Nebraska Medical Center) Michelle Gasko, toxicology grad student at UNMC while on an internship at VT

Polymer-coated Magnetite Nanoparticles have High NMR Relaxivities Judy S. Riffle and Richey M. Davis (VA Tech), DMR , in collaboration with Tim St. Pierre and Robert Woodward, School of Physics, University of Western Australia, Perth Polymer % Magnetite R 2 (s -1 ) 5.6kPPO- 7.2kPEO PPOk- 3.8kPEO kPPO- 4.8kPEO kPPO- 2.6kPEO Ferridex-81 Transverse NMR relaxivities of magnetite nanoparticles are very sensitive to the block lengths and hydrophobic-hydrophilic relationships of their polymer coatings, and it is not yet clear why this is so. High relaxivities are associated with faster MRI diagnostics and the opportunity to reduce the concentration of contrast agents. Select PPO-b-PEO coatings yield relaxivities four times higher than current commercial sources.

Materials World Network for the Study of Macromolecular Ferrofluids Judy S. Riffle and Richey M. Davis (VA Tech), DMR , in collaboration with Tim St. Pierre and Robert Woodward, School of Physics, University of Western Australia, Perth Left to right, front row, Nikorn Pothayee (VT), Annette Tyler (UWA), back row, Tim St. Pierre (UWA), Rob Woodward (UWA), Phil Huffstetler (VT), Thompson Mefford (former VT student, now Ass’t Prof, Clemson), Matt Carroll (UWA), Jon Goff (VT), Judy Riffle (VT) Working group meeting with VA Tech and UWA: held in conjunction with the 6 th International Conference on Scientific and Clinical Applications of Magnetic Carriers, May, 2008, Vancouver, CA We presented 10 papers!