Alcohol and Ovarian Cancer Publication Genkinger, JM, et al.. Br J Cancer 2006 Mar 13;94(5):757-62. Genkinger, JM, et al. Alcohol intake and ovarian cancer.

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Alcohol and Ovarian Cancer Publication Genkinger, JM, et al.. Br J Cancer 2006 Mar 13;94(5): Genkinger, JM, et al. Alcohol intake and ovarian cancer risk: A pooled analysis of ten cohort studies. Br J Cancer 2006 Mar 13;94(5):

Genkinger et al, 2006 Swedish Mammography Cohort (SMC) Netherlands Cohort Study (NLCS) New York State Cohort (NYSC) Iowa Women’s Health Study (IWHS) Canadian National Breast Screening Study (CNBSS) Cohort studies in the pooled analysis of alcohol intake and ovarian cancer Cancer Prevention Study II Nutrition Cohort (CPS II) Breast Cancer Detection Demonstration Project Follow-up Study (BCDDP) Total cohort size= 529,638 Total # of cases = 2,001 Nurses’ Health Study (NHSa, NHSb), Nurses’ Health Study II (NHS II), Women’s Health Study (WHS)

Genkinger et al, 2006 Cohort studies in the pooled analysis of alcohol intake and ovarian cancer Study Follow-upYearsBaselineCohort#Cases Baseline Age Range, years BCDDP , CNBSS , CPS II , IWHS , NLCS , NYSC , NHSa , NHSb , NHS II , SMC , WHS ,

Genkinger et al, 2006 Median Intakes (Interquartile Range) of Alcohol Among Drinkers by Cohort Study Median Intake(g/day) Among Drinkers CohortPercent of Drinkers Total Alcohol Intake Alcohol Intake from Wine Alcohol Intake from Beer Alcohol Intake from Spirits from Spirits BCDDP ( ) 1.4 ( ) 0.9 ( ) 2.2 ( ) CNBSS ( ) 3.1 ( ) 1.7 ( ) 2.3 ( ) CPS II ( ) 1.4 ( ) 0.9 ( ) 2.1 ( ) IWHS ( ) 1.7 ( ) 1.8 ( ) 2.1 ( ) NLCS ( ) 3.2 ( ) 1.1 ( ) 4.6 ( ) NYSC ( ) NHS(a) ( ) 1.5 ( ) 1.8 ( ) 2.0 ( ) NHS(b) ( ) 1.8 ( ) 1.8 ( ) 2.0 ( ) NHS II ( ) 1.5 ( ) 2.0 ( ) 1.2 ( ) SMC ( ) 1.8 ( ) 0.9 ( ) 1.0 ( ) WHS ( ) 1.7 ( ) 1.8 ( ) 2.1 ( )

Genkinger et al, 2006 Study-Specific and Pooled Multivariate Adjusted RR and 95% CI for Ovarian Cancer According to Intake of Total Alcohol Study Categories of Alcohol Intake (g/day) >30 BCDDP 1.00 (Ref) 1.25 ( ) 1.39 ( ) 1.70 ( ) 2.21 ( ) CNBSS 1.00 (Ref) 0.90 ( ) 1.21 ( ) 1.10 ( ) 1.27 ( ) CPS II 1.00 (Ref) 1.07 ( ) 0.85 ( ) 0.82 ( ) 0.79 ( ) IWHS 1.00 (Ref) 1.28 ( ) 0.87 ( ) 0.71 ( ) 0.75 ( ) NLCS 1.00 (Ref) 1.06 ( ) 1.07 ( ) 0.77 ( ) 1.79 ( ) NYSC 1.00 (Ref) 0.98 ( ) 0.28 ( ) 0.41 ( ) 0.53 ( ) NHSa 1.00 (Ref) 0.90 ( ) 0.82 ( ) 0.92 ( ) 0.78 ( ) NHSb 1.00 (Ref) 1.13 ( ) 0.85 ( ) 1.52 ( ) 0.87 ( ) NHS II 1.00 (Ref) 0.94 ( ) 0.73 ( ) 0.60 ( ) 1.59 ( ) SMC 1.00 (Ref) 1.04 ( ) 1.04 ( ) 1.19 ( ) --- WHS 1.00 (Ref) 0.78 ( ) 1.10 ( ) 1.04 ( ) 1.66 ( ) Cases Pooled 1.00 (Ref) 1.06 ( ) 0.96 ( ) 1.09 ( ) 1.12 ( )

Genkinger et al, 2006 Pooled Age and Multivariate Adjusted RR and 95% CI for Ovarian Cancer According to Intake of Alcohol from Specific Beverages Categories of Alcohol Intake (g/day) WineRange >15 Cases Age RR 1.00 (Ref) 1.04 ( ) 1.05 ( ) 1.21 ( ) MV RR 1.00 (Ref) 1.03 ( ) 1.03 ( ) 1.18 ( ) Beer Cases Age RR 1.00 (Ref) 1.11 ( ) 0.76 ( ) 1.40 ( ) MV RR 1.00 (Ref) 1.09 ( ) 0.75 ( ) 1.38 ( ) Spirits Cases Age RR 1.00 (Ref) 1.01 ( ) 1.03 ( ) 1.17 ( ) MV RR 1.00 (Ref) 1.01 ( ) 1.02 ( ) 1.16 ( )

Genkinger et al, 2006 Pooled Multivariate RR and 95% CI for a 15g/day Increment in Total Alcohol Intake by Levels of Hormonal/Reproductive Ovarian Cancer Risk Factors, Continuous Model FactorCases Relative Risk (95% CI) P-value, test for Interaction Hormonal/Reproductive Parity (live birth) Parity (live birth) < 1< 1< 1< ( ) > ( ) >0.99 Oral Contraceptive Use Oral Contraceptive Use Never ( ) Ever ( ) 0.41 Hormone Replacement Therapy Hormone Replacement Therapy Never ( ) Past ( ) Current ( ) 0.39 Menopausal Status at Diagnosis Menopausal Status at Diagnosis Premenopausal ( ) Postmenopausal ( ) 0.24

Genkinger et al, 2006 Pooled Multivariate RR and 95% CI for a 15g/day Increment in Total Alcohol Intake by Levels of Nutritional Factors, Continuous Model FactorCases Relative Risk (95% CI) P-value, test for Interaction Nutritional Methionine Intake (Median) Methionine Intake (Median) Low ( ) High ( ) 0.34 Folate Intake (Median) Folate Intake (Median) Low ( ) High ( ) 0.18 Multivitamin Use Multivitamin Use No ( ) Yes ( ) 0.56

Genkinger et al, 2006 Pooled Multivariate RR and 95% CI for a 15g/day Increment in Total Alcohol Intake by Levels of Other Ovarian Cancer Risk Factors, Continuous Model FactorCases Relative Risk (95% CI) P-value, test for Interaction Other Smoking Status Smoking Status Never ( ) Past ( ) Current ( ) 0.52 Body Mass Index (kg/m 2 ) Body Mass Index (kg/m 2 ) < ( ) 23-<25 23-< ( ) 25-<30 25-< ( ) > ( ) 0.74