Inflammation and repair Dr Shaesta Naseem 19-09-13.

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Presentation transcript:

Inflammation and repair Dr Shaesta Naseem

Inflammation and repair

Gross and histopathology

1- Fibrinous pericarditis

Organ: Pericardium Dx: Fibrinous Inflammation

ACUTE FIBRINOUS PERICARDITIS

Fibrinous Pericarditis: Section of Heart shows: The pericardium is distorted by thick irregular layer of pinkish fibrinous exudate with some red cells and inflammatory cells. The subpericardial layer is thickened by edema and shows dilated blood vessels, chronic inflammatory cells and areas of calcification.

2- Acute appendicitis

ACUTE APPENDICITIS

Acute appendicitis

ACUTE APPENDICITIS Accumulation of inflammatory exudate and pus cells in the lumen The mucosa is ulcerated

ACUTE APPENDICITIS Infiltration by many neutrophils. Edema Dilated and congested blood vessels

Acute Suppurative appendicitis: Cross Section of Appendix shows: On gross, fibrino-purulent exudate is present on the serosal surface. Accumulation of inflammatory exudate and pus cells in the lumen and the mucosa is ulcerated. All layers of the appendix wall show edema, dilated and congested blood vessels and infiltration by many neutrophils.

3-Skin pilonidal sinus

3- FOREIGN BODY REACTION (PILONIDAL SINUS) Sinus tract with surrounding inflammation and hairs

FOREIGN BODY REACTION (PILONIDAL SINUS) Hair Shaft

Foreign Body reaction (Pilonidal sinus): Section of Skin Shows: A sinus tract lined by an inflammatory granulation tissue in the dermis. The lumen of sinus and wall contain large number of hair shafts with foreign body giant cells, lymphocytes, macrophages & neutrophils.

4-Chronic cholecystitis with stones

CHRONIC CHOLECYSTITIS Rokitansky- Aschoff sinuses

Chronic cholecystitis: Section of gallbladder wall shows: Irregular mucosal folds and foci of ulceration in mucosa. Wall is penetrated by mucosal glands which are present in muscle coat ( Rokitansky- Aschoff sinuses). All layers show chronic inflammatory cells infiltration and fibrosis.

5- Brain abscess

6- Granulation tissue

GRANULATION TISSUE (Inflammatory vascular granulation tissue)

GRANULATION TISSUE  Edema  Chronic inflammatory infiltration  Proliferating blood vessels

Granulation Tissue: Section of fragments of edematous, loose connective tissue shows: Many small newly formed capillaries lined by plump endothelial cells. Proliferation of fibroblasts is seen. Inflammatory cells including macrophages, lymphocytes, plasma cells and neutrophils in the oedematous stroma. Pink homogenous collagen fibres may be identified.