Eric Niederhoffer SIU-SOM How are CO 2, NO, and O 2 processed and transported? A 40-year-old man complains of progressive exertional shortness of breath.

Slides:

Advertisements

Similar presentations

Lecture – 6 Dr. Zahoor Ali Shaikh

Advertisements

Review exam questions. XxwY.

Transport of CO 2 Dissolved in plasma As bicarbonate ions As carbamino Hb or Carbamino Proteins Under normal resting conditions,an average of 4 ml of CO.

Oxygen Binding Proteins

Blood Gas Transport Dr Taha Sadig Ahmed Physiology Dept College of Medicine King Saud University Riyadh.

GAS TRANSPORT OXYGEN(O2) & CARBONDIOXIDE(CO2)

Myoglobin and Hemoglobin

Figure 49.2 The Double Bind of Water Breathers. Figure 49.3 Gas Exchange Systems.

Eric Niederhoffer SIU-SOM What affects the normal functions of an erythrocyte? A 4-year-old African boy is brought in by his adoptive parents who say that.

The Respiratory System: Gas Exchange and Regulation of Breathing

Respiratory Bohr Effect Alterations in hemoglobin’s structure Alterations in hemoglobin’s structure Shift to the right in the oxyhemoglobin dissociation.

Synthesis of Heme Copyright © by Joyce J. Diwan. All rights reserved. Molecular Biochemistry II.

Structure, function and metabolism of hemoglobin

Hemoglobin synthesis, structure & function

Biochemistry Sixth Edition

1 Respiratory system L4 Faisal I. Mohammed, MD, PhD University of Jordan.

AP Biology Why do we need a respiratory system? O2O2 food ATP CO 2  Need O 2 in  for aerobic cellular respiration  make ATP  Need CO 2 out  waste.

Structures of Myoglobin and Hemoglobin

Gas Exchange and Transport

Bound and Dissolved Oxygen in the Blood of Most Animals.

Iron and heme metabolism © Michael Palmer Functions of heme Redox chemistry ● electron transport: cytochromes in the respiratory chain ● enzyme.

Transport and exchange of O 2 and CO 2 Lungs:pH 7.4Temp 37 °C Tissues:pH 7.38Temp 38 °C.

Pathophysiology of Heme Synthesis Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2006.

Ventilation/Perfusion Ratios in the Lung. O 2 Transport in the Blood O 2 is bound to hemoglobin (Hb) for transport in the blood –Oxyhemoglobin: O 2 bound.

NITROGEN BIOSYNTHETIC PATHWAYS BIOC 460 DR. TISCHLER LECTURE 39.

Chapter 22 Respiratory System Lecture 8 Part 2: O2 and CO2 Transport

Pathophysiology of Heme Synthesis Beth A. Bouchard BIOC 212: Biochemistry of Human Disease Spring 2005.

Carbon Dioxide Transport

HIV protease + drug inhibitor

Myoglobin and hemoglobin

Structure, function, and metabolism of hemoglobin

Transport of Oxygen and carbon dioxide

Chapter 16 Hemal Biochemistry The biochemistry and molecular biology department of CMU.

About this Chapter Diffusion and solubility of gases

HEME SYNTHESIS DR AMINA TARIQ BIOCHEMISTRY. HEME PROTEINS These are a group of specialized proteins that contain heme and globin. Heme is the prosthetic.

CHMI E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Quaternary structure.

Hemoglobin, an AllostericProtein. Hemoglobin vs Myoglobin Hemoglobin (Hb): - found in red blood cells - responsible for transport of O 2 from lungs to.

Carriage of respiratory Gases By Y Stock. Objectives  You should be able to:  Describe the structure of erythrocytes.  Describe the role of respiratory.

Porphyrins and Porphyrias Dr. Zeyad El-Akawi Jreisat, M.D, M.A, Ph.D.

PORPHYRIAS  A group of rare disorders caused by deficiencies of enzymes of the heme biosynthetic pathway  Affected individuals have an accumulation of.

Overview The Sites of Heme Biosynthesis are: 1.The liver, which synthesizes a number of heme proteins (particularly cytochrome P450). 2.The bone marrow,

Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings Concept 42.7: Respiratory pigments bind and transport gases The metabolic demands.

ACID-BASE BALANCE  AIMS:  What are acids and bases?  What is pH?  Why does pH vary?  How do you regulate pH?

3-D Structure / Function. Myoglobin/ Hemoglobin First protein structures determined Oxygen carriers Hemoglobin transport O 2 from lungs to tissues Myoglobin.

Protein Function Function relies on interactions with other molecules Binding of molecules to proteins is reversible Ligand = Binding site = HIV protease.

Transport of O 2 in blood: 1. Some dissolved  1.5% at normal atmospheric pressure 2. Most combined with hemoglobin  98.5%

Respiration III  Partial pressure of gases  O 2 and CO 2 transport in the blood  Ventilation and acid-base balance.

Structure Hemoglobin –Tetramer of  2  2 –Each subunit binds one heme –Oxygen transporter in RBCs Myoglobin –Monomer with one heme –Oxygen reservoir.

Metabolism of tetrapyrrols Pavla Balínová. Tetrapyrrols circular compounds binding a metal ion (most frequently Fe 2+ and Fe 3+ ) consist of 4 pyrrol.

George III Mary, Queen of Scot Attempted murder of Elizabeth I Executed 1587 James I Intermittent Porphyria Purple Urine George I (great grandfather) -

Hemoglobin and Myoglobin These are conjugated proteins.A simple protein has only a polypeptide chain. A conjugated protein has a non-protein part in addition.

Gas Exchange Part 2: Gas Exchange and Oxygen Dissociation

TRANSPORT OF RESPIRATORY GASES BY BLOOD. OXYGEN TRANSPORT  Bound to hemoglobin  Dissolved in plasma  1.5% of the oxygen transported is carried in the.

Biochemical role of Hemoglobin

Iron and heme metabolism

F211: Exchange & transport

RESPIRATORY SYSTEM LECTURE-6 (GAS TRANSPORT)

Oxygen and Carbon dioxide Transport

Human respiratory system

Faisal I. Mohammed, MD, PhD

Chapter 22 – The Respiratory System

Transport of CO2.

Dr. Shumaila Asim Lecture # 2

Dry Atmospheric Gas at Standard Barometric Pressure Po torr Pco torr PN torr.

Human Anatomy and Physiology II

The Bohr effect.

Proteins: Quaternary structure

PGC-1α: Looking behind the Sweet Treat for Porphyria

Oxygen and Carbon dioxide Transport

TRANSPORT OF OXYGEN AND

Presentation transcript:

Eric Niederhoffer SIU-SOM How are CO 2, NO, and O 2 processed and transported? A 40-year-old man complains of progressive exertional shortness of breath A 4-year-old African boy is brought in by his adoptive parents who say that he has pain in his limbs and does not want to walk How is heme synthesized?

Small Molecule Processing and Transport CO 2 processing and transport carbonic anhydrase, anion exchanger, carbamate formation, Bohr effect NO processing and transport glutathione O 2 processing and transport hemoglobin/myoglobin structure, allostery, cooperativity Heme synthesis pathway, disorders

CO 2 Processing and Transport CO 2 H2OH2O CA H 2 CO 3 H + Hb Hb(O 2 ) 4 O2O2 HCO 3 - O2O2 HbNH 2 HbNH-CO 2 - H+H from tissues to tissuesplasma Cl - AE1 CO 2 H2OH2O CA H 2 CO 3 H + Hb Hb(O 2 ) 4 O2O2 HCO 3 - O2O2 HbNH 2 HbNH-CO 2 - H+H to air from airplasma Cl - AE1 Percent Distribution of CO 2 SpeciesArterialVenous Carbamino530 HCO CO 2 dissolved 810

NO Processing and Transport

Hemoglobin Structure Changes

Factors Affecting Binding of O 2 Depends on pH ([H + ]), CO 2, BPG, Temp

Factors Affecting Binding of O 2 Adaptation Figures from /ch10/index.html

Heme Synthesis mit SCoA + Gly 5-Aminolevulinic acid synthase 5ALA PBG Porphobilinogen synthase PBG deaminase Hydroxymethylbilane Uroporphyrinogen III synthase UPGIII UPGIII decarboxylase CPGIII Coproporphyrinogen oxidase PPGIX PPIX Protoporphyrinogen oxidase Ferrochelatase Heme Pb

Review Questions How are CO 2 and NO processed and transported? How are myoglobin and hemoglobin similar and different? What portion of hemoglobin is involved in small molecule transport? What allosteric effectors bind hemoglobin? How do allosteric effectors produce left and right shifts of the hemoglobin-O 2 binding curves? How is heme synthesized? How is heme synthesis regulated?