Overview of the Harvard Catalyst Imaging program Randy Gollub,MD,PhD; Ron Kikinis, MD; Bruce Rosen, MD, PhD;Clare Tempany, MD; Valerie Humblet, PhD April 14, 2009

Harvard Catalyst: The History and the Basics 1 GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued –BWH/MGH imaging cores CTSA 2007(Roadmap initiative) HU- Response-Harvard Catalyst –(PI Lee Nadler/Co-Director: Steve Freedman) –GCRC at BWH incorporated in Center for Clinical Investigation We are a pan-Harvard enterprise dedicated to improving human health by: –Creating Connections –Enabling research At the Cutting Edge of discovery –Nurturing clinical and translational researchers

National Effort in C/T Research 38 AHC/23 states 2 Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 Source: Duke Mayo Clinic Cornell J.Hopkins UC Davis Wash. U. Northwestern Emory U. Imaging programs-(Dan Sullivan/RSNA)

Institutions participating in Harvard CTSC 3 Academic Healthcare Centers Beth Israel-Deaconess Medical Center Brigham and Women’s Hospital Massachusetts General Hospital Children’s Hospital Boston Specialty Hospitals and Institutes Dana-Farber Cancer Institute Forsyth Dental Institute Joslin Diabetes Center Massachusetts Eye and Ear Infirmary McLean Hospital Schepens Eye Research Institute Massachusetts Institutes of Technology Harvard University Faculty of Arts and Sciences Harvard Business School Harvard School of Dental Medicine Harvard Divinity School Graduate School of Design Graduate School of Education Kennedy School of Government Harvard Law School Harvard Medical School Harvard School of Public Health Harvard School of Engineering Community Healthcare Institutions Cambridge Health Alliance HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare Red –Imaging Consortium Yearly budget: $38 million (23 NIH + 15 matching)

Harvard Catalyst Programs (Selected list) –Development of Novel C/T Methodologies –Biomedical Informatics –Research Education, Career Development –Pilot studies –Community Engagement –Design and Biostatistics –Diversity and Health Disparities Research –Ethics –Linkages across the institutions –Regulatory Knowledge and Support 4

Harvard Catalyst Programs –Translational Technologies and Resources Imaging and Genetics –increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies. 5

Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, XNAT Engineer Imaging Consortium Team 6

Mission of the Imaging Consortium 7 Expand imaging in clinical research –Build infrastructure (software, image analysis and visualization tools, cross-site acquisition tools) –Provide expert consultation in the use of imaging as part of clinical translational research –Educate and advise about available imaging and image processing capabilities in the Harvard environment. –Provide education at the local and national level (participation in RSNA education program)

Harvard Catalyst website 8

Harvard Catalyst website

Image Consortium Consultation Service 10

Image Consortium Consultation Service 11

Technologies and Expertise 12 Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging. Focused on assisting with planning and design of research proposals and/or methods for image analysis. Consultation is available for the preparation of a grant or IRB submission. We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies.

Examples of Imaging Consultation 13 Standardization of physiologic monitoring system for MRI. Development of lingual nerve imaging (MGH- BIDMC) Multi-site structural and functional neuroimaging (BIDMC-MGH)

Examples of Imaging Consultation 14 Study of brain-development in premature infants (CHB-BWH-MGH) Slicer (BWH): quantitative tractography ( Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation in Infants (MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center

Medical Imaging Informatics 15 Examples: –Clinical: Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? Quantitative output from Freesurfer for Alzheimer disease –Research: Helping TIMC get easier access to PACS system for clinical trials

Medical Imaging Informatics 16 IT Catalyst infrastructure: –i2b2: scalable computational framework to help translation of genomic findings. –BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. –NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer.

XNAT Enterprise Data Repository (CRC) File Repository Identity Management Ontology Management Correlation Analysis De - Identification Of data Natural Language Processing Annotating Genomic Data #1 Project Management Workflow Framework Annotating Genomic Data #2 PACS i2b2 HIVE Dr X Desktop Pediatric rare disease Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr W Desktop Quantitative cancer biomarkers Medical Imaging Informatics 17

Educational Opportunities proposal 18 Nanocourse: –Imaging 101 to increase knowledge about imaging More advanced classes for radiologists: –Tumor metrics –Radiation safety issues for IRB submission –Hands-on classes on data analysis –Imaging perfusion –Example:

Pilot funds Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. First round: 62 projects funded (out of 602) Funds: Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected) Deadlines: Letter of intent: May 13, 2009 Full application: June 12, 2009 Contact: Harvard Catalyst Research Navigators

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