PHYSIOLOGY OF LEUKOCYTES.

Function of leukocytes 1. Protective 1. Protective 2. Transport 2. Transport 3. Metabolic 3. Metabolic 4. Regenerator 4. Regenerator

Quantity of leukocytes and their changes White cells are nucleated and somewhat variable in size and shape. Their number is 4-9Giga per liter. The number of lymphocytes are – %, White cells are nucleated and somewhat variable in size and shape. Their number is 4-9Giga per liter. The number of lymphocytes are – %, monocytes – 3-11 %, monocytes – 3-11 %, eosinophils –0,5-5 %, eosinophils –0,5-5 %, basophils – 0-1 %, basophils – 0-1 %, juvenile neutrophile – 0-1 %, juvenile neutrophile – 0-1 %, relating to stab (rod-shaped) neutrophil – 1-6 %, relating to stab (rod-shaped) neutrophil – 1-6 %, segmented neutrophil – %. segmented neutrophil – %. The number of leukocytes may increase or decrease. The number of leukocytes may increase or decrease.

Development of monocytes common progenitor cell – common progenitor cell – uncommited stem cell – uncommited stem cell – commited stem cell – commited stem cell – monoblast – monoblast – promonocyte – promonocyte – monocyte – monocyte – tissue macrophage. tissue macrophage.

Development of lymphocytes common progenitor cell – common progenitor cell – bone marrow lymphocytes precursor – bone marrow lymphocytes precursor – lymphoblast – lymphoblast – prolymphocyte – prolymphocyte – large lymphocyte – large lymphocyte – small lymphocyte. small lymphocyte. Lymphocytes in the fetus are thought to arise first in the thymus. Later they are found in lymph nodes, spleen, and other lymphoid tissues as well as in bone marrow. Lymphocytes in the fetus are thought to arise first in the thymus. Later they are found in lymph nodes, spleen, and other lymphoid tissues as well as in bone marrow.

Development of gtanulocytes common progenitor cell – common progenitor cell – uncommited stem cell – uncommited stem cell – commited stem cell – commited stem cell – myeloblast (basophil, neutrophil, eosinophil) – promyelocyte – myeloblast (basophil, neutrophil, eosinophil) – promyelocyte – myelocyte – myelocyte – metamyelocyte – metamyelocyte – juvenile – juvenile – rod-shaped neutrophil (basophil, eosinophil), rod-shaped neutrophil (basophil, eosinophil), segmented neutrophil, basophil, eosinophil. segmented neutrophil, basophil, eosinophil.

Physiological role of T-lymphocytes 1. Immune memory. 1. Immune memory. 2. Anti viruses immunity. 2. Anti viruses immunity. 3. Anti tissue immunity. 3. Anti tissue immunity. 4. Regulate phagocytosis. 4. Regulate phagocytosis. Function of В-lymphocytes Function of В-lymphocytes 1. Immune memory. 1. Immune memory. 2. Specific immunity. B-lymphocytes syntheses the immunoglobulins such as IgM, IgN, IgA, IgG, IgB, IgE. 2. Specific immunity. B-lymphocytes syntheses the immunoglobulins such as IgM, IgN, IgA, IgG, IgB, IgE.

System of mononucleares phagocytes These is the system, which common the cells with one nucleus, These is the system, which common the cells with one nucleus, common origin from red bone marrow, common function of high specific phagocytosis common origin from red bone marrow, common function of high specific phagocytosis

EOSINOPHILS

The index of nuclear’s changing of neutrophyls, it interpretation NCN=(M+J+S1)/S2, where NCN=(M+J+S1)/S2, where M – myelocytes, M – myelocytes, J– juvenile, J– juvenile, S1 – stab neutrophils, S1 – stab neutrophils, S2 – segmented neutrophils S2 – segmented neutrophils Norm is 0,06-0,09 Norm is 0,06-0,09

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