L4 L7 TB4 TB7 Regulation of Genes Relevant to General Immune Response C6Complement component 6, facilitates clearance of antigen-antibody complexes C1RComplement component 1r, facilitates clearance of antigen-antibody complexes CD59Inhibitor of the membrane attack complex LTB4DHCatalyses conversion of leukotriene B4 into its less active metabolite C7Complement component 7, facilitates clearance of antigen-antibody complexes C1RComplement component 1r, facilitates clearance of antigen-antibody complexes DAFAntagonist of the complement cascade C3AR1Complement component 3a receptor 1 IL1RAPEssential for activation of interleukin 1-associated kinase MMP15Tissue remodeling (reactivity and plasticity of lymphoid tissue) MMP25Tissue remodeling (reactivity and plasticity of lymphoid tissue) PTX3Acute phase reactant induced by interleukin 1beta in vascular endothelial cells Regulation of Genes Relevant to Interferon Pathways G1P3Inducible by interferon alpha SP110Inducible by interferon gamma IFIT1Inducible by interferon alpha, IL1, retinoic acid, viral infection IFNGR1Interferon gamma receptor 1 IFI16Inducible by interferon gamma and later by interferon alpha MNDAResponsive to interferon alpha IRF2Represses interferon alpha/beta and interferon-induced MHC Class I JAK1Janus kinase 1 (a protein tyrosine kinase) IFRD2interferon-related developmental regulator 2 PKRHomo sapiens double stranded RNA activated protein kinase (PKR) gene, intron 4 IFNARReceptor for interferon alpha/beta IFNAR2Receptor for interferon alpha/beta/omega CCL11Responsive to interferon gamma, IL1, TNFalpha MX1Myxovirus (influenza virus) resistance 1, inducible by interferons alpha, beta, gamma IFNGinterferon, gamma IFITM1Inducible by interferon alpha and gamma IL13Downregulates interferon gamma IRF7Induces interferon alpha IFITM2Inducible by interferon alpha and gamma IFITM3Inducible by interferon alpha and gamma L4 L7 TB4 TB7

Regulation of Genes Relevant to Immune Cell Migration DPTAdhesion protein expressed in connective tissue ITGBL1Integrin, beta-like 1 ITGA2BIntegrin, alpha 2b SDC2Syndecan 2, heparin sulfate proteoglycan CXCL12Attracts both T lymphocytes and monocytes IL8Attracts neutrophils and T cells CXCR6Chemokine receptor present on activated T cells and lymphoid tissue IL8Attracts neutrophils and T cells CCL3Attracts neutrophils CD44Plays a role in lymphocyte homing to lymph nodes ICAP-1ARecruit integrins β-1 to the focal contacts during cell adhesion CCL5Chemoattractant for T helper cells and monocytes CCL28Chemoattractant for T helper cells and cytotoxic T cells ITGB1Beta 1 integrin isoform CD47Transduces signals from integrins, facilitates neutrophil migration & activation ITGALIntegrin, alpha L PECAM-1Cell adhesion molecule on endothelial cells, monocytes, neutrophils, & certain T cells AOC3Adhesion protein on high endothelial venules of lymph nodes, chemoattractants for T cells SELESelectin E (endothelial adhesion molecule 1) CCL11Chemokine induced by interleukin 1, TNF α, and interferon γ ITGB3BPIntegrin beta 3 binding protein CXCL11Chemoattractant for activated T cells CMKBR3Chemokine receptor for T helper 2 cells CXCR3Chemokine receptor for interferon-inducible proteins ICAM2Lymphocyte recirculation from lymph nodes and MK cell-mediated clearance L4 L7 TB4 TB7 L4 L7 TB4 TB7 Regulation of Genes Relevant to Antigen Presentation on MHC Complexes HSPA2Heat shock protein A2, may play a role in processing of MHC Class I complexes HLA-DOBMajor histocompatibility complex, class II, DO beta HLA-AMajor histocompatibility complex, class I, A HLA-CMajor histocompatibility complex, class I, C HERPUD1ER stress-inducible, ubiquitin-like domain member 1 PSMA1Proteasome subunit involved in antigen processing for presentation CALRCalreticulin, heat shock protein important in processing MHC Class I complexes HSP89-alphaHeat shock protein 89-alpha, may be involved in processing of MHC Class I complexes SERPINH1Heat shock protein 47, may be involved in processing of MHC Class I complexes IFNARStimulation during type I INF response causes MHC Class I induction in infected cells IFNAR2Stimulation during type I IFN response causes MHC Class I induction in infected cells HSPA9Bheat shock 70kDa protein 9B (mortalin-2) TRAP1Heat shock protein 75 HLA-DQA1Major histocompatibility complex, class II, DQ alpha 1 Regulation of Genes Relevant to Neutrophil Function EBI2Expressed in pro-myelocytic cell lines IL2RBMediates Induction of stem cells into myeloid development IL8Attracts and activates neutrophils CCL3Chemotactic factor for neutrophils AOAHPhagocytosis by neutrophils C3AR1Stimulates granule release and superoxide production CSF2RBReceptor for stimulation factor of granulocytes MNDAStimulation of myeloid cells CD47Facilitates neutrophil migration and activation ITGALAntibody-dependent neutrophil killing PECAM-1Cell adhesion molecule present on neutrophils TNFSF14Expressed in granulocytes and mediating T cell proliferation MMP2Facilitates egress of neutrophils from lung parenchyma to airways MMP9Present in neutrophils IL3Growth stimulation factor of granulocytes c-fmsUpregulated in stem cells induced into myeloid development IL2RAMediates induction of stem cells into myeloid development MMP7Facilitates egress of neutrophils from lung parenchyma to airways

L4 L7 TB4 TB7 L4 L7 TB4 TB7 Regulation of Genes Relevant to Monocyte/Macrophage Function CES1Detoxifying enzyme specific to alveolar macrophages CXCL12Attracts monocytes EBI2Expressed in pro-myelocytic cell lines IL2RBMediates in induction of stem cells into myeloid development IL15Produced by monocytes TNFSF5Expressed on macrophages, mediates cytokine production CSF2RBReceptor for stimulation factor of macrophages MNDAStimulation of myeloid cells PDE4BInvolved in signal transduction in monocytes CD80Expression on B cells is induced by secretion of ICAM1 by macrophages CD84Expressed by monocytes CCL5Chemoattractant for monocytes ITGALAntibody-dependent macrophage killing PECAM-1Cell adhesion molecule present on monocytes TNFSF14Expressed in monocytes and mediating T cell proliferation LILRB1Expressed on monocytes MMP2Facilitates egress of macrophages from lung parenchyma to airways MMP9Present in alveolar macrophages IFNGSecreted by macrophages LILRB2Expressed on monocytes IL3Growth stimulation factor of macrophages c-fmsUpregulated in stem cells induced into myeloid development IL2RAMediates in induction of stem cells into myeloid development MRC1Macrophage mannose receptor TGFB3Expressed in macrophages Regulation of Genes Relevant to NK cell Function GZMACytotoxicity GZMBCytotoxicity TNFRSF6Involved in cytotoxic functions of NK cells IL15Induces differentiation of NK cells KLRC1Inhibitory lectin-like receptor present on NK cells KIR3DL2Inhibitory killer immunoglobulin-like receptor present on NK cells TNFSF6Involved in cytotoxic functions of NK cells KLRC4Inhibitory lectin-like receptor present on NK cells KLRC3Inhibitory lectin-like receptor present on NK cells KLRD1Inhibitory lectin-like receptor present on NK cells KIR2DL3Inhibitory killer immunoglobulin-like receptor present on NK cells NKG2-DInhibitory lectin-like receptor present on NK cells IL5RABinds IL5 secreted by NK cells JAK3Tyrosine kinase expressed by NK cells LILRB1Inhibitory immunoglobulin-like receptor present on NK cells IFNGinterferon, gamma, produced by NK cells LILRB2Inhibitory immunoglobulin-like receptor present on NK cells ICAM2Plays a role in NK cell-mediated clearance Regulation of Genes Relevant to Dendritic Cell Function TNFSF11Augments the ability of dendritic cells to stimulate naïve T cells to proliferate CD80Expressed by dendritic cells LY75Antigen uptake receptor on dendritic cells LILRB1Inhibitory immunoglobulin-like receptor present on dendritic cells LILRB2Inhibitory immunoglobulin-like receptor present on dendritic cells

Regulation of Genes Relevant to T cell Function GZMACytotoxicity GZMBCytotoxicity CXCL12Attracts T cells TNFSF11Stimulation of naïve T cells to proliferate CXCL12Attracts T cells TNFRSF6Apoptosis of non-activated T cells and Tc cell-mediated apoptosis IL2RBMediates activation of T cells, and required for IL15-induced T cell proliferation LNKAdaptor protein between the T cell receptor and proteins participating in T cell activation IL15Induces proliferation of T cells KLRC1Inhibitory killer immunoglobulin-like receptor present on Tc cells IL8Chemoattractant for T cells TNFSF5Expressed on T cells and implicated in inflammatory cytokine production KIR3DL2Inhibitory killer immunoglobulin-like receptor present on Tc cells IL8Chemoattractant for T cells TNFSF6Apoptosis of non-activated T cells and Tc cell-mediated apoptosis LAKlymphocyte alpha-kinase, participates in the T cell activation pathway KLRC4Inhibitory lectin-like receptor present on Tc cells IFI16Induced by interferon in lymphocyte, acts as a transcriptional repressor TNFSF4OX40L induced on antigen-presenting cells after interaction with T cells IL1RAPChemoattractant and pro-inflammatory for T cells KLRC3Inhibitory lectin-like receptor present on Tc cells KLRD1Inhibitory lectin-like receptor present on Tc cells KIR2DL3Inhibitory killer immunoglobulin-like receptor present on Tc cells CD7Marker of T cells CD80T lymphocyte stimulation, proliferation, cytokine production, interacts with CD28 or CTLA4 CD84Adhesion interactions between T cells and other cells TNFSF7lymphocyte activation, proliferation, and generation of Tc cells CD44Lymphocyte homing to lymph nodes JAK1Involved in lymphocyte activation, cell cytotoxicity, and apoptosis CCL5Chemoattractant for T helper cells FASTKMediates apoptosis of mature T cells through caspase pathways and cytotoxicity CCL28Chemoattractant for T helper cells and cytotoxic T cells ITGB1Involved in lymphocyte activation and cytotoxicity IFNARInvolved in T cell survival & in enhancement of production of interferon gamma by T cells IL5RABinds IL5 secreted by Tc and T helper cells to differentiate B cells to produce antibodies ITGALLymphocyte activation, cytotoxicity, apoptosis, recirculation of lymphocytes from LN JAK3Functional competence of mature Tc cells TNFSF14Stimulates proliferation of T cells IFNAR2Involved in T cell survival & in enhancement of production of interferon gamma by T cells AOC3Chemoattractant for T cells, recirculation of immune cells CXCL11Chemoattractant for activated T lymphocytes IFNGProduced by Tc cells CMKBR3Expressed in T helper 2 cells which activate B cells to produce antibodies IL2RAMediates activation of T cells, and required for IL15-induced T cell proliferation ICAM2Lymphocyte recirculation from lymph nodes L4 L7 TB4 TB7

L4 L7 TB4 TB7 Regulation of Genes Relevant to B Cell Function EBI2Mediator of lymphocytic functions IL2RBinterleukin 2 receptor, beta, present on B cells KLRC1killer cell lectin-like receptor subfamily C, member 1 TNFSF5tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) KIR3DL2Inhibitory killer immunoglobulin-like receptor present on B cells KLRC3Inhibitory lectin-like receptor present on B cells PDE4BInvolved in signal transduction in B cells KLRD1Inhibitory lectin-like receptor present on B cells KIR2DL3Inhibitory killer immunoglobulin-like receptor present on B cells CD80B cell stimulation, interacts with CD28 or CTLA4 on T cells CD84 On B cells, interacts with T cells NFKB1Nuclear transcription factor of the kappa light chain in B cells IL5RAB cell receptor, differentiation of B cells into antibody-producing cells JAK3Tyrosine kinase, plays a role in B cell development LILRB1Inhibitory immunoglobulin-like receptor present on B cells TCF3Facilitates transcription of immunoglobulin in B cells PTPN7Stress-induced protein tyrosine kinase acting as a tumor suppressor in pre-B cells IL2RAinterleukin 2 receptor, alpha, present on B cells TNFRSF17B cell maturation factor, which promotes B cell survival