Chapter 11.3 Genetic Changes
Mutations Sudden genetic change Point mutations Frameshift mutation Chromosomal mutation www.chemistryexplained.com/images/chfa_03_img
www.catpaws.dk/images/mutation.jpg
Point Mutation Single base pair in DNA Ex: Normal – AUG AAG UUU GGC Point - AUG AAA UUU GGC Happens at a single point, you point to one thing.
Frameshift Mutation Addition or deletion of a single base Ex: Normal – AUG AAG UUU GGC Frameshift – AUG AAG UU GGC Think KEYBOARD
Chromosomal Mutation Change in chromosomes Causing nondisjunction (to many or not enough parts) – failure of chromosomes to separate Trisomy – extra chromosome Monosomy – missing chromosomes Triploidy – an extra set - plants mostly
Source: www.brooklyn.cuny.edu/.../MUT/Mut.Types.html
Mutations Some mutations can be positive – mutation may make an organism faster, stronger Mutations may be passed on if it occurs in reproductive cells, will not be passed on however in nonreproductive cells (skin, muscle, or bone.)
Mutagen Any agent that can cause a change in DNA
Causes of Mutations (Mutagens) Error in DNA Radiation – x-ray exposure, gamma radiation, cosmic rays, UV, nuclear Chemicals – dioxins, asbestos, benzene, cyanide, formaldehyde, radioactive chemicals
Results of Mutations Birth Defects Cancer
Repairing DNA Enzymes proofread the DNA and replace incorrect nucleotides with correct ones