Animal form and function: endocrine
Controls Animals have 2 systems of control Nervous: rapid response Endocrine: slower response. Longer lasting Reception: hormone binds receptor protein on target cell (or in) Change receptor protien: initiates transduction Hormones (steroid): bind protein in cytosol: enter nucleus as transcription factors and turn genes off or on. Signal transduction: binding triggers events within the cell Response: change in cells behavior
Types of signals Endocrine: long distance stim. Carried through blood stream Paracrine: local. Stim neighboring cells Neurotransmitters Growth factors prostoglandins
Endocrine example: epinephrine Epinephrine is secreted from the adrenal medulla in response to stress. Receives Neural stimulus from hypothalmus Epinephrine stimulates the breakdown of glycogen to glucose in the muscle and liver Sutherland found: in test tube epinephrine + glycogen phosphorylase + glycogen = no work Need intact cells and cell membrane Epinephrine uses G protein-linked receptors: binds on outside of cell: stims change in G protein in cytosol. Makes it active
FYI: epinephrine stimulates: Dilation of capillaries in the lungs Increased heart rate and cardiac output Smooth muscles of some blood vessels contract, others dilate
Remember cell signaling Hormones that act inside the cell (steroids) transcription factors G-protein linked receptors: on cell membrane: act on protein in the cytosol (change out the guanine) making it active Tyrosine kinase: catalyze the transfer of a phosphate group from ATP to tyrosine Ion gated channels: affected by the level of certain ions in the extracellular fluid (Na)
Glands of endocrine Hypothalamus Pineal Pituitary Thyroid Thymus Adrenals Pancreas Ovaries/ testes
Hypothalamus Hypothalamus makes hormones and stores them in: Posterior pituitary: oxytocin: uterine contraction ADH: anti diuretic hormone (decrease urination) Anterior pituitary: Secretes trophic hormones: control other glands: regulated by hypothalmus ACTH: adrenal control FSH/LH: gonad regulation Growth hormone: growth regulation Prolactin: milk production TSH: thyroid stim
Hypothalamus Hypothalamus: TSH releasing hormone Stims Anterior Pituitary to release: TSH Stims Thyroid: release T3 and T4 Negative feedback: T3 and T4 negative feedback to hypothal. A signal transduction pathway with cAMP as 2 nd messenger
Thyroid Thyroid Thyroxine: metabolic rate Calcitonin: decreases blood calcium Parathyroid PTH: when Ca++ is low, PTH stim osteoclasts to breakdown bone and kidneys to retain Ca++ so, raises Blood calcium
Pancreas Exocrine: digestive enzymes: through DUCT to small intestine Endocrine: Islets of Langerhan: Alpha cells: glucagon Beta cells: insulin Glucagon: stim breakdown of glycogen Insulin: increases cells ability to take up glucose. And stim. the storage of glucose as glycogen in liver and muscles
Adrenal glands Adrenal Medulla Stim by acetylcholine from sympathetic nerve system Epinepherine norepinepherine Adrenal Cortex Glucocorticoids: aldosterone
Blood Pressure Blood volume low: Kidneys secrete renin Stims angiotensin from liver: constricts blood vessels Stims aldosterone from adrenal cortex Kidney tubules increase reabsorbtion of water Antiduiretic hormone works in same situation
Ovaries & testes Ovaries Estrogen progesterone Testes Testosterone
Pineal gland Melatonin: involved in light/dark cycles