PHOS-ISTOS D EVELOPMENT OF BIOPHOTONIC DEVICE BASED ON FLEXIBLE LIGHT EMITTING TEXTILE DEDICATED TO THE MONITORING AND TREATMENT FOR DERMATOLOGIC DISEASES.

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Presentation transcript:

PHOS-ISTOS D EVELOPMENT OF BIOPHOTONIC DEVICE BASED ON FLEXIBLE LIGHT EMITTING TEXTILE DEDICATED TO THE MONITORING AND TREATMENT FOR DERMATOLOGIC DISEASES AND CARCINOMA

C ONTEXT Actinic Keratosis (AK) Cutaneous carcinoma in situ Scaly erythematous plaque Caused by sun damage Epidemiology: In Europe a prevalence of 15 % in men and 6 % in women has been documented Over the age of 70 years, 34 % of males and 18 % of females were found to have AKs Evolution 10% risk to develop into invasive Squamous Cell Carcinoma 2 Localization on sun-exposed areas

C ONTEXT Photodynamic therapy (PDT) for Actinic Keratosis Destruction of the AK cells by the interaction between three elements: Photosensitizer: Protoporphyrin IX Generated from a topical photosensitizing agent Selectively accumulated in the target cells Light of appropriate wavelength Oxygen in sufficient quantities in the target cells 3

C ONTEXT Photodynamic therapy (PDT) for Actinic Keratosis Benefits Cure rates between 69 and 93 % Excellent cosmetic results: no scare Drawbacks Important variation in cure rates  Perfectible Very painful therapy Half a day equipment occupancy per patient Cost and limited availability of equipment (only available in specialized environment) 4

O BJECTIVES 5 Objective: To increase the efficiency of treatment Solutions proposed by Phos-Istos: To ensure illumination homogeneity using a flexible light emitting textile To determine in real time the optimal treatment parameters by monitoring the PDT reaction Conventional rigid LED panels: Flexible light emitting textile proposed by Phos-Istos:

O BJECTIVES 6 Objective: To manage patient pain Solutions proposed by Phos-Istos: To ensure oxygen in sufficient quantities using light fractionation (succession of illumination and rest periods) To provide a cooling effect on the affected area Fractionated illumination proposed by Phos-Istos: Conventional continuous illumination: ON t OFF t ON Reoxygenation during rest periods

O BJECTIVES 7 Objective: To extend the use of PDT Solutions proposed by Phos-Istos: To miniaturize the system for ambulatory use To limit the cost of the ambulatory system Conventional PDT systems: Ambulatory system proposed by Phos-Istos:

E VALUATION 8 Comparative clinical evaluation of the light emitting textile for AK Efficacy assessments: Complete (or not) disappearance of lesions 3 months after treatment Safety assessments Pain assessment during treatment Assessment of adverse effects (erythema, crusting…) 1-3 days after treatment. PDT using conventional red light-emitting diode light PDT using the light emitting textile

10 P ARTNERS 9 Institut National de la Santé et de la Recherche Médicale REDEN MODULIGHT TEXINOV KLINIKUM VEST GMBH EREO Centre Hospitalier Régional et Universitaire de Lille FLUENCE THERAPEUTICS Ecole Nationale Supérieure des Arts et Industries Textile (ENSAIT) PROPLAST