Copyright © 2009 Pearson Education, Inc. Art and Photos in PowerPoint ® Concepts of Genetics Ninth Edition Klug, Cummings, Spencer, Palladino Chapter 12.

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Copyright © 2009 Pearson Education, Inc. Art and Photos in PowerPoint ® Concepts of Genetics Ninth Edition Klug, Cummings, Spencer, Palladino Chapter 12 DNA Organization in Chromosomes Copyright © 2009 Pearson Education, Inc.

12.1Viral and Bacterial Chromosomes Are Relatively Simple DNA Molecules

Copyright © 2009 Pearson Education, Inc. Figure 12.1

Copyright © 2009 Pearson Education, Inc. Table 12.1

Copyright © 2009 Pearson Education, Inc. Figure 12.2

Copyright © 2009 Pearson Education, Inc.

Figure 12.3

Copyright © 2009 Pearson Education, Inc.

12.2 Supercoiling Facilitates Compaction of the DNA of Viral and Bacterial Chromosomes

Copyright © 2009 Pearson Education, Inc. Figure 12.4

Copyright © 2009 Pearson Education, Inc. Figure 12.4a

Copyright © 2009 Pearson Education, Inc. Figure 12.4b

Copyright © 2009 Pearson Education, Inc. Figure 12.4c

Copyright © 2009 Pearson Education, Inc. Figure 12.4d

Copyright © 2009 Pearson Education, Inc. 12.4DNA Is Organized into Chromatin in Eukaryotes Chromatin Structure and Nucleosomes

Copyright © 2009 Pearson Education, Inc. DNA Fun Fact Length of DNA in human cell ~ 2 meters No. of cells in human body ~10 14 So, total length of DNA in human body ~ 2 x meters = 2 x km Distance from Earth to Sun ~ 1.5 x 10 8 km This means that you have enough DNA in your body to stretch back and forth between the Earth and Sun 1000 times!

Copyright © 2009 Pearson Education, Inc. Table 12.2

Copyright © 2009 Pearson Education, Inc. Figure 12.8

Copyright © 2009 Pearson Education, Inc. Figure 12.8a

Copyright © 2009 Pearson Education, Inc. Figure 12.8b

Copyright © 2009 Pearson Education, Inc. ~200 bp 147 bp digest linker DNA

Copyright © 2009 Pearson Education, Inc.

Figure 12.9

Copyright © 2009 Pearson Education, Inc.

12.4DNA Is Organized into Chromatin in Eukaryotes High Resolution Studies of the Nucleosome Core

Copyright © 2009 Pearson Education, Inc. Figure 12.10

Copyright © 2009 Pearson Education, Inc. 12.4DNA Is Organized into Chromatin in Eukaryotes Heterochromatin

Copyright © 2009 Pearson Education, Inc Chromosome Banding Differentiates Regions along the Mitotic Chromosome

Copyright © 2009 Pearson Education, Inc. Figure 12.11

Copyright © 2009 Pearson Education, Inc. Figure 12.12

Copyright © 2009 Pearson Education, Inc. Figure 12.13

Copyright © 2009 Pearson Education, Inc Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA

Copyright © 2009 Pearson Education, Inc. Figure 12.14

Copyright © 2009 Pearson Education, Inc Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA Satellite DNA

Copyright © 2009 Pearson Education, Inc. Figure 12.15

Copyright © 2009 Pearson Education, Inc. Figure 12.16

Copyright © 2009 Pearson Education, Inc Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA Centromeric DNA Sequences

Copyright © 2009 Pearson Education, Inc. Centromeric DNA Sequences “point” versus “regional” centromeres

Copyright © 2009 Pearson Education, Inc. Figure 12.17

Copyright © 2009 Pearson Education, Inc Eukaryotic Chromosomes Demonstrate Complex Sequence Organization Characterized by Repetitive DNA Telomeric DNA Sequences Middle Repetitive Sequences: VNTRs and STRs Repetitive Transposed Sequences: SINEs and LINEs Middle Repetitive Multiple-Copy Genes

Copyright © 2009 Pearson Education, Inc The Vast Majority of a Eukaryotic Genome Does Not Encode Functional Genes “C- value paradox”