Systematic identification of 3′-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons by Jonathan E. Cohen, Philip R. Lee,

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Systematic identification of 3′-UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons by Jonathan E. Cohen, Philip R. Lee, and R. Douglas Fields Philosophical Transactions B Volume 369(1652): September 26, 2014 ©2014 by The Royal Society

Activity-dependent, post-transcriptional gene regulation experiment. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369: ©2014 by The Royal Society

(Opposite.) Rapid, post-transcriptional regulation in hippocampal neurons mirrors activity- regulated genes in DRG axons. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369: ©2014 by The Royal Society

Discovery of enriched motifs for destabilized and stabilized genes. 3′-UTR analysis by MEME on downregulated (destabilized) and upregulated (stabilized) transcripts by MEME identifies miRNA-binding sites. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369: ©2014 by The Royal Society

Predicted miRNAs are developmentally regulated in the hippocampus and may control nervous system development. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369: ©2014 by The Royal Society

miR-485 blocks NGF-induced neurite outgrowth in PC12 cells. miR-485 overexpression inhibits NGF-induced neurite outgrowth in PC12 cells. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369: ©2014 by The Royal Society

miR-485 decreases tau expression in hippocampal neurons. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369: ©2014 by The Royal Society

miR-485 overexpression controls tau expression and axonal outgrowth in hippocampal neurons. miR-485-5p overexpression reduced the extent of axonal outgrowth in hippocampal neurons. Jonathan E. Cohen et al. Phil. Trans. R. Soc. B 2014;369: ©2014 by The Royal Society