The Differences of Depth Parameters of Deposits Depending on the Morphology in Granular Corneal Dystrophy Type Ⅱ by Fourier Domain Optical Coherence Tomography.

Slides:

Advertisements

Similar presentations

Financial Disclosure Calhoun Vision consultant, equity Clarity Massey Labs consultant, equity.

Advertisements

Endothelial Cell Changes as an Indicator for Upcoming Allograft Rejection Following Descemet Membrane Endothelial Keratoplasty Jack Parker Jr, MD; Lamis.

Corneal biomechanical properties and their association with intraocular pressure (IOP) and central corneal thickness (CCT) Dimitrios P. Bessinis 1, Pandelis.

Corneal morphology in Epithelial Basement Membrane Dystrophy: A large cross-sectional study with in vivo confocal microscopy Johan Germundsson M.D, Per.

Swept Source Optical Coherence Tomography for Evaluation of Posterior Corneal Changes after Refractive Surgery Dr. Tommy Chung Yan Chan Dr. Vishal Jhanji.

Severe Phenotypes of Granular Corneal Dystrophy Type 2 and Genetic Analysis Results Yong Woo Ji, MD, Eung Kweon Kim, MD, PhD, Seung-Il Choi, PhD, Bong-Yoon.

Department of Ophthalmology, University Hospital Ayr, Scotland

Influence of Keratoplasty Technique on Corneal Biomechanical Properties in Keratoconus Hans R Vellara, Noor Q Ali, Charles NJ McGhee, Dipika V Patel Department.

1 Swept Source Frequency Domain Optical Coherence Tomography Swept Source Frequency Domain Optical Coherence Tomography Anurag Gupta University of Rochester,

Grand Rounds Amir R. Hajrasouliha, M.D. University of Louisville Department of Ophthalmology and Visual Sciences Friday, June 20th, 2014.

Anterior Chamber Depth, Iridocorneal Angle Width, and Intraocular Pressure Changes After Phacoemulsification: Narrow vs Open Iridocorneal Angles Huang.

Director: Gulani Vision Institute Jacksonville, Florida

Macular Corneal Dystrophy

Outcome of refractive surgery in keratoconus suspect eyes

Contrast-Enhanced Corneal Wound Imaging by Optical Coherence Tomography Preeya K. Gupta, MD Justis P. Ehlers, MD Terry Kim, MD Duke Eye Center, Durham,

So-Hyang Chung, MD, PhD, Choun-Ki Joo, MD, PhD Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul,

Somasheila I. Murthy, Prashant Garg, Pravin K. Vaddavalli

Clear Corneal Incisions (CCIs) and innovative blade design in C-MICS Dan Calladine - No financial interests Richard Packard – Consultant for Core Surgical.

INTRA OPERATIVE ONLINE PACHY METRY –A SAFETY TOOL Dr. KUMAR J DOCTOR DOCTOR EYE INSTITUTE MUMBAIINDIA NO FINANCIAL INTEREST.

TRANSPALPEBRAL TONOMETER APPLICATION DURING INTRAOCULAR PRESSURE EVALUATION IN THE PATIENTS WITH REFRACTION ANOMALY BEFORE AND AFTER KERATOPHOTOREFRACTIVE.

Evaluation of Epithelial Changes in Limbal Stem Cell Deficiency Using in Vivo Confocal Microscopy ERIC CHAN, Luxia Chen, Sophie X. Deng Cornea and Uveitis.

A Novel Technique to Diagnose and Follow up Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High Resolution Optical Coherence Tomography.

Ki Cheol Chang, MD 1, 2, Mee Kum Kim, MD 1, 2, Won Ryang Wee, MD 1,2, Jin Hak Lee, MD 2,3, Beom Seok Jeon, MD 4 Department of Ophthalmology, Seoul National.

Ocular Pathology Case Presentation Kristin Rarey, M.D. February 2010.

Photorefractive Keratectomy in Posterior Polymorphous Dystrophy [CONTROL ID: ] Edward W. Trudo 1, Kraig S. Bower 2, Charles D. Coe 2, Denise A. Sediq.

Effect of CXL on FS laser Channel Creation for ICR in KC Tamer M. El-Raggal, MD, PhD, FRCSEd Associate Professor of Ophthalmology Ain Shams University,

Mee Kum Kim 1,2, Kyoung Min Lee 1,2, Young Eun Lee 1,2, Won Ryang Wee 1,2 1 Department of Ophthalmology, Seoul National University College of Medicine,

Clinical outcomes of Epi-LASIK : 1-Year-Long Results of Flap ON/OFF with Mitomycin-C ON/OFF Gil-Joong Yoon (MD/PhD) 1 Seong-Taeck Kim (MD) 2 Jae-Woong.

Khairidzan Mohd Kamal MD

Different epithelial cleavage planes produced by various epikeratomes in Epi-LASIK Doh Lee, M.D., Ph.D. 1, Suk kyue Choi, M.D. 1, Jin Hyoung Kim, M.D.

Clinical outcome of DALK in Keratoconus – A one year follow up

Comparison of Central Corneal Thickness and Peripheral Corneal Thickness using Sheimpflug system, Optical Coherence Tomography and Ultrasound Pachymetry.

1 Non-contact Specular Microscopy for Evaluation of Corneal Endothelium in Early Fuchs’ Endothelial Corneal Dystrophy Jianyan Huang 1, MD, PhD; Tudor Tepelus.

The Effect of Corneal Anterior Surface Eccentricity on Astigmatism after Cataract Surgery Choul Yong Park MD 1 Sung Jun Lee MD 1 Prabjot Channa MD 2 Roy.

King Saud University College of Medicine

SALK IN REFRACTIVE SURGERY INDUCED CORNEAL OPACITY- A VIABLE OPTION Anita Ganger, Radhika Tandon, Murgesan Vanathi Cornea & Ocular Surface Services, Dr.

10 year follow up of LASIK surgery for low to high levels of myopia Qasim Qasem FRCS, Caitriona Kirwan MRCOpth, Michael O’Keefe FRCS. Institutional Affiliations:

Jae Lim Chung MD, MBA 1,3 ; Jin Pyo Hong MD 2,3 ; Kyoung Yul Seo MD, PhD 3 ; Eung Kweon Kim MD, PhD 3 ; Tae-im Kim MD, PhD Noo Ne Eye Hospital, Seoul,

Comparison of Central Corneal Thickness, Anterior Chamber Depth, and Central Corneal Power Measurements between Two Scheimpflug Imaging Systems Yuichi.

PTERYGIUM PROGRESSION DETECTED BY IN VIVO CONFOCAL MICROSCOPY Martone Gianluca, Malandrini Alex, Balestrazzi Angelo, Tosi Gian Marco, Pichierri Patrizia,

Long Term Results of Femtosecond Laser-Assisted Sutureless Anterior Lamellar Keratoplasty “FALK” Mohamed Abou Shousha, MD, Sonia H. Yoo, MD, William Feuer,

Simulated Experiments on IOL Power Calculation Using Anterior Segment OCT Dong Hyun Jo, M.D., 1,2 Mee Kum Kim, M.D., 1,2 Won Ryang Wee, M.D. 1,2 1 Department.

Evaluating Post Laser Refractive Surgery Corneal Thickness Using Artemis-2 Very High Frequency Arc-Scanning Ultrasonography Versus Pentacam * † Sharon.

Corneal dystrophies. Corneal dystrophies Corneal dystrophies Group of progressive , usually bilateral , mostly genetically determined , non inflammatory.

The results of PTK using Fourier-Domain Optical Coherence Tomography for Granular Corneal Dystrophy Type 2 Eung Kweon Kim, MD, Ph.D 1 ; Tae-im Kim, MD,

1. Ankara University School of Medicine, Department of Ophthalmology

and Microperimetry visual field parameters for Glaucomatous Loss

Varsha Rathi DO, P K Vaddavalli MS, S Murthy MS, V S Sangwan, MS

The Efficacy and Safety of the Low Intensity Ultrasound Treatment in Patients with Open Angle Glaucoma Hyoung Won Bae, Gong Je Seong, Chan Yun Kim Institute.

Reproducibility of retinal thickness measurements in eyes with

Department of Ophthalmology, University of Ulsan College of Medicine,

Correlation between visual acuity

Characteristics of Primary Angle-Closure Glaucoma Patients with Normal Intraocular Pressure at the First Visit Won Hyuk Oh1, Bum Gi Kim1, Joo Hwa Lee2.

Eun Chul Kim, M.D. , Man Soo Kim,M.D.

Outcome of LASIK in Pre-Descemet’s Membrane Corneal Dystrophy

Intraocular lens repositioning in a glaucoma patient with recurrent pupillary capture Kyoung Tak Ma¹, Hyung Won, Bae² , Gong Je Seong², Chan Yun Kim².

Maria A Henriquez MD Luis Izquierdo MD Jackeline Parraga MD

Moran Eye Center, University of Utah

Clinical effect of citicoline combined with choline alfoscerate for treatment of glaucomatous optic neuropathy Karliychuk M.A., Pinchuk S.V. Department.

Fig. 3. Slit-lamp photographs

Comparison of Central Corneal Thickness measured by

Wylegala Edward, Nowinska Anna

Three-Year Follow-up after LASIK in Eye with Extremely Thin Corneal Bed Hidemasa Torii, MD, Kazuno Negishi, MD, Murat Dogru, MD, Takefumi Yamaguchi, MD,

Sun Woong Kim, M.D.1, Hae Jung Sun, M.D.1,

Optical Coherence Pachymetry with the ESIRIS DOCTOR EYE INSTITUTE

Corneal Biomechanics after Penetrating Keratoplasty and Descemet’s Stripping Automated Endothelial Keratoplasty Samer Hamada MRCOphth FRCS(Ed)1,3 Louai.

The authors have no financial interest

Authors have no financial interest.

Hyuck Jin Choi, Joo Youn Oh, Won Ryang Wee, Mee Kum Kim,

Jun Her MD. PhD, Sung-wook Kim MD, Jae-hwan Ahn MD

Presentation transcript:

The Differences of Depth Parameters of Deposits Depending on the Morphology in Granular Corneal Dystrophy Type Ⅱ by Fourier Domain Optical Coherence Tomography Jin Pyo Hong,MD 1, Jae Lim Chung,MD 1, Jung Won Park,MD 2, Tae-im Kim,MD,PhD 1, Kyoung Yul Seo,MD,PhD 1, Eung Kweon Kim,MD,PhD 1 1 Corneal Dystrophy Research Institute, Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea 2 Daegu Yonsei Eye Clinic, Daegu, Korea Authors have no financial interest

Purpose Granular corneal dystrophy type Ⅱ (GCD Ⅱ )  Arg124His mutation in the Bigh-3 gene  Histologic feature of hyaline granules and amyloid lattice lines  Granular deposits as the earliest manifestation  Lattice deposits as later presentation  Diffuse haziness as getting older Surgical treatment of GCD Ⅱ  Phototherapeutic keratectomy(PTK)  Penetrating keratoplasty(PKP)  Lamellar keratoplasty(LKP) The depth of different deposits according to the patterns  Should be identified before surgery  Critical to decide which treatment modalities  Such as PTK, PKP, LKP

Purpose Fourier domain optical coherence tomography, RTVue- 100 ® (Optovue Inc, Fremont, CA)  High speed, high resolution tomography scanning  5 μm depth resolution  Layer by layer assessment  26,000 A scan/second  0.04 second of one B scan acquisition Purpose of this study  To evaluate the differences of depth parameters depending on morphology of deposits using Fourier domain optical coherence tomography, RTVue- 100 ®

Methods Patients  54 patients were evaluated  Heterozygous GCD Ⅱ by gene analysis  No history of uveitis, glaucoma, other ocular surface disease, previous operation Methods  Standardization of measuring CCT for RTVue-100® with ultrasonic pachymeter 20 normal subjects (40 eyes) 13 GDCII patients (23 eyes)  3 Classifications of deposits detected by RTVue-100® Granular, lattice, diffuse haziness  Recurrent deposit after refractive surgery  Two points for each different deposits per one patient

Methods Classification  Type I – diffuse haziness  Type II – granular deposits Type IIa – round granulated Type IIb – round spiculated  Type III – lattice deposits Type IIIa – spiculated lattice Type IIIb – conventional lattice (with long branches) Parameters  Following parameters measured from Bowman’s layer perpendicularily Distance of upper surface from Bowman’s layer(USBL) Distance of lower surface from Bowman’s layer(LSBL) Thickness of deposits(TD) LSBL TD USBL Bowman’s layer

Results Standardization of measuring CCT for RTVue-100 ® with ultrasonic pachymeter CCTRTVueUltra sonop Normal subjects (n=40) 526.3± ± GCDII patients (n=23) 528.6± ± p Type I  diffuse haziness (white arrow)

Results Type IIa  Round granulated (white arrow) Type IIb  Round spiculated (white arrow)

Results Type IIIa  Spiculated lattice (white arrow) Type IIIb  Conventional lattice (white arrow)

Results Recurrent deposits after LASIK

Results The various parameters of deposits Diffuse haziness (n=58) Granular deposits (n=59) Lattice deposits (n=74) P USBL0065.4±48.0<0.001 LSBL47.7± ± ±71.4<0.001 TD47.7± ± ±71.9<0.001 The differences of depth between granular deposits (Type IIa vs Type IIb) Parameters of granular deposits P Round granulated (n=45)Round spiculated (n=14) USBL00- LSBL85.7± ± TD85.7± ±

Results The differences of depth between two different shaped lattice trunks(Type IIIa vs Type IIIb) Parameters of lattice trunks P Spiculated lattice (n=14)Conventional lattice (n=45) USBL62.2± ± LSBL305.7± ± TD242.5± ± The differences of depth between trunks and limbs of lattice with long branches (Type IIIb) Parameters of lattice(n=74) P Trunkslimbs USBL67.1± ±110.1< LSBL321.9± ± TD253.0± ±40.9< Parameters of recurrent deposits after LASIK (n=15) Parametersmean±SD (min – max) Mean depth of center of deposits84.9±43.6 (22 – 191) Mean maximum thickness85.6±24.9 (47 – 125) Mean minimum thickness45.1±18.0 (22 – 85)

Conclusion 1st report investigating in vivo the depth of deposits depending on the morphology Three deposits had three distinct depths  Diffuse haziness at the superficial layer  Granules at ant. stroma  Lattice deposits at mid to post. Stroma No differences of depth between two shaped lattice deposits Easily detected by RTVue-100 ® in case slit lamp examination can not reveal the depth Most of all  Guide the treatment modality according to what the main pattern of deposits are in the visual axis, such as PTK, DLKP, PKP by in vivo measuring with RTVue-100 ®