© Chemometric Optimization Of A SIA Promethazine Hydrochloride Assay Method Idris, AM; Assubaie, FN; Sultan, SM ELSEVIER SCIENCE BV, MICROCHEMICAL JOURNAL; pp: 7-13; Vol: 83 King Fahd University of Petroleum & Minerals Summary A sequential injection analysis (SIA) method for the assay of promethazine hydrochloride, based on its oxidation by acidified cerium(W), was optimized. Three chemometric approaches were applied: (i) factorial design (3(3) applied to surface plot and 2(3) applied to effect factor) for screening the potential interacting variables, (ii) univariant for optimizing insignificantly interacting variables and (iii) simplex for optimizing potentially interacting variables. The optimum experimental conditions were 30 mu l of 0.38 mol/l sulphuric acid, 30 mu l of 3.99 x 10(-3) mol/l cerium(IV), 20 mu l of promethazine hydrochloride and 20 mu l/s flow rate. The detection limit was x 10(-5) mol/l and the calibration curve was linear up to mol/l with a correlation coefficient , accuracy range of %, relative standard deviation 1.1 % (n = 10) and sample frequency at least 20 samples/h. The method was applied to tablet form and validated with the British Pharmacopoeia method. The developed SIA method is fully automated, reproducible, sensitive, rapid and reagent- saving, and therefore suitable for routine control in tablets form. (c) 2006 Elsevier B.V All rights reserved. References: *BRIT PHARM, E COP CD VER 6 0 *GRAB SOL, 2000, MULTISIMPLEX US GUID *US PHARM, 2003, E COP CD VER 26 NF 2 ALWARTHAN AA, 1993, ANAL CHIM ACTA, V282, P169 AMAN T, 2003, ANAL LETT, V36, P2961, DOI /AL BASAVAIAH K, 1998, TALANTA, V47, P59 Copyright: King Fahd University of Petroleum & Minerals;
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