Unit Six: Blood Cells, Immunity, and Blood Coagulation

Slides:



Advertisements
Similar presentations
17 Blood.
Advertisements

BLOOD Chapter 10.
Blood cells. Types of blood cells Red blood cells Macrophage system Lymphatic system.
Overview of Vessels Arteries: blood vessels that move AWAY from the heart Veins: vessels that move TOWARD the heart Capillaries: Small vessels created.
Alterations of Erythrocyte Function
Chapter 18 Blood Part A.
Lecture – 3 Dr. Zahoor Ali Shaikh
BIOL 2304 Fall 2006Chapter 171 Chapter 17 - Blood.
Learning Objectives of today’s Revise –Erythropoiesis –Regulation of Erythropoiesis Fate of RBCs.
Chapter 17: Blood. William Harvey Discovered the nature of blood and circulation with the heart.
Week 6 Dr. Walid Daoud, A. Professor
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Fundamentals of Anatomy & Physiology SIXTH EDITION Frederic H. Martini PowerPoint.
Notes : Blood Magette Eudora High School.
Aims Lymphatics. Blood composition Blood clotting Readings; Sherwood, Chapter 10 & 11; Robbins, pages
Mostly water that _ – Nutrients, gas, hormone, wastes, ions, proteins – Most abundant solutes are the _ Blood Plasma.
Two types of tissues for secretion – ______________________________________ ____: digestive juices deposited into the duodenum – ______________________________________.
COMPOSITION AND FUNCTION OF BLOOD
Anemia Dr Gihan Gawish.
Lecture – 2 Dr. Zahoor Ali Shaikh
Chapter 14: The Cardiovascular System- Blood. Functions of the Blood 1)Transportation -Gases (O 2 and CO 2 ) -Nutrients -Heat and waste -Hormones 2)Regulation.
Red Blood cells = rbc’s =erythrocytes I.Structure = function Biconcave discs, no nucleus*, 4-5 million per uL of blood II.Erythropoiesis = erythrocyte.
Arsalan Yousuf BS 4th Semester
BIO 265 – Human A&P Chapter 17 - Blood. Preview of Circulation Figure 18.5.
Chapter 7 Diseases of the Blood. Elsevier items and derived items © 2009 by Saunders, an imprint of Elsevier Inc. 1 Terms  Erythrocytes: Red blood cells.
Chapter 14 Blood. Structure & Function Blood is a type of connective tissue (consists of cells in a matrix) Function – pH – Volume – 5L (in avg. adult.
Erythropoiesis Dr.Salah Elmalik Department of Physiology
White blood cells Platelets Red blood cells Artery.
Blood Physiology Professor A.M.A Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of Medicine & The Blood Bank,
ERYTHROCYTES [RBCs] Lecture – 2 Dr. Zahoor Ali Shaikh 1.
Blood Physiology Professor A. M. A Abdel Gader MD, PhD, FRCP (Lond
HEMATOLOGY/ HEMATOPOIESIS Introduction. HEMATOLOGY Introduction Study of blood & its components Window of rest of body.
Circulatory System BLOODBLOOD OVERVIEW OF FUNCTIONS TRANSPORT A.OF RESPIRATORY GASES O 2 & CO 2 B.NUTRIENTS C.METABOLIC WASTES D.HORMONES E. HEAT.
Chapter 11 Blood Functions transports vital substances
BLOOD AND BODY DEFENCE Dr. Amel Eassawi Dr. Abdelrahman Mustafa 1.
Lecture 2 Red Blood Cells, Anemias & Polycythemias
E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.
Control of erythropoiesis, iron metabolism, and hemoglobin
Red Blood Cells Formation and structure.
BLOOD Disorders.
Hematopoiesis (The formation of Blood Cells)‏
Regulation of Erythropoiesis Dr Ghulam Mustafa Regulation of Erythropoiesis Importance Factors affecting Erythropoiesis  Tissue Oxygenation Anemia,
Chapter 14 Blood. Structure & Function Blood is a type of connective tissue (consists of cells in a matrix) Function – transports O 2 & nutrients, maintains.
Red blood Cell Changes and Circulatory problems
BLOOD CELLS. LEC 2 Nov Objectives Objectives Types of blood cells Types of blood cells 2.Hemopoiesis(Hematopoiesis) 2.Hemopoiesis(Hematopoiesis)
Chapter 15: Blood.
Dr Nervana Bayoumy TEXTBOOK OF MEDICAL PHYSIOLOGY GUYTON & HALL 11 TH EDITION UNIT VI CHAPTERS
Objectives : When you complete this section ,you should be able to :
ERYTHROCYTE II (Anemia Polycythemia)
Anemia.
Copyright © 2009 Pearson Education, Inc., publishing as Benjamin Cummings Photomicrograph of a Blood Smear -- review Figure Which type of blood.
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Chapter 17 Blood.
Physiology of Red Blood Cells (RBCs) Erythrocytes
Introduction Physiology is the study of the living things
Professor A.M.A Abdel Gader MD, PhD, FRCP (Lond., Edin), FRSH (London) Professor of Physiology, College of Medicine King Khalid University Hospital Riyadh,
Review - Anemias/WBCs. Hemolytic Anemia Arrows indicate cells being destroyed; Acquired (thru certain chemicals) or inherited RBCs are destroyed before.
Blood Physiology Red Blood Cells.
Review - Anemias/WBCs. Hemolytic Anemia Arrows indicate cells being destroyed; Acquired (thru certain chemicals) or inherited.
Cardiovascular System 11-1 to 11-4
Objectives At the end of this lecture student should be able to:
BLOOD PHYSIOLOGY Dr Nervana Bayoumy TEXTBOOK OF MEDICAL PHYSIOLOGY
Topics of this lecture : RBC
The Hematologic and Lymphatic Systems and Assessment
BLOOD PHYSIOLOGY Lecture 2
Polycythemia.
Dr. Shaikh Mujeeb Ahmed Assistant Professor AlMaarefa College
2 Basic Types of Bone Marrow
Introduction Physiology is the study of the living things
BLOOD PHYSIOLOGY Lecture 2
BLOOD PHYSIOLOGY Dr Nervana Bayoumy TEXTBOOK OF MEDICAL PHYSIOLOGY
Packed cell volume count (Hematocrit)
Presentation transcript:

Unit Six: Blood Cells, Immunity, and Blood Coagulation Chapter 32: Red Blood Cells, Anemia, and Polycythemia Guyton and Hall, Textbook of Medical Physiology, 12th edition

Red Blood Cells Red Blood Cells (Erythrocytes) Transport hemoglobin Contain carbonic anhydrase (acid-base buffering) Shape and size of rbcs-pliable Concentration in the blood- 40-45% Quantity of hemoglobin in the cells- 14-15 g/100 ml of cells

Production of Red Blood Cells Fig. 32.1 Relative rates of rbc production in the bone marrow of different bones at different ages

Pluripotential Hematopoietic Stem Cells Genesis of Blood Cells Pluripotential Hematopoietic Stem Cells Fig. 32.2

Stages of Differentiation of RBCs Genesis of Blood Cells Stages of Differentiation of RBCs Fig. 32.3

Red Blood Cells (cont.) Regulation of RBC Production-Erythropoietin Tissue oxygenation is the most essential regulator of rbc production Erythropoietin stimulates rbc production, and its formation increases in response to hypoxia Role of the kidney-90% of the erythropoietin is formed in the kidney (liver-10%)

Red Blood Cells (cont.) Fig. 32.4 Function of the erythropoietin mechanism to increase production of rbcs when tissue oxygenation decreases.

Red Blood Cells (cont.) Maturation of RBCs Requirement for Vitamin B12 and Folic acid Maturation failure with poor absorption of B12-leads to pernicious anemia Maturation failure with poor absorption of Folic acid- leads to sprue (usually occurs in association with the vitamin deficiency

Formation of Hemoglobin Red Blood Cells (cont.) Formation of Hemoglobin Fig. 32.5 Formation of hemoglobin Fig. 32.6 Basic structure of hemoglobin

Red Blood Cells (cont.) Iron Metabolism Transport and storage of iron- transferrin, ferritin Daily loss of iron (0.6 mg/day; feces) Absorption of iron from the GI tract Regulation of total body iron by controlling the rate of absorption

Red Blood Cells (cont.) Iron Metabolism Fig. 32.7 Iron transport and metabolism

Red Blood Cells (cont.) Life Span of RBCs is about 120 Days Destruction of Hemoglobin Fe is carried by transferrin to bone marrow Fe is stored as ferritin Porphyrin ring is converted to bilirubin

Anemias Blood Loss Anemia- hemorrhage Aplastic Anemia- lack of functioning bone marrow Megaloblastic Anemia- slow reproduction of erythroblasts Hemolytic Anemia- abnormalities of rbcs Effects on the Circulatory System- low blood viscosity, decreased resistance to blood flow, increased CO, increased workload on the heart

Polycythemia Secondary Polycythemia- abnormal quantities of rbcs Polycythemia vera (Erythremia)- genetic aberration Effects on the Circulatory System- CO and arterial pressure is normal, blood is sluggish passing through the capillaries and skin color may take on a bluish cast