Thymocyte System Analysis Cells: Type Anatomical site Migration Receptor profile State markers Proliferation Apoptosis Molecules: Cytokines, etc. Interactions:

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Thymocyte System Analysis Cells: Type Anatomical site Migration Receptor profile State markers Proliferation Apoptosis Molecules: Cytokines, etc. Interactions: Organ: Cell type DPDN SP Cell phase G1 G2 S M Receptor Profile Cell movement Interactions Expression Apoptosis Cell memory CD44 hi CD44 lo Up Down Object 1 Object 2 TNF IL1

Cell Phase

Concept of RA

Cell Motifs for Animation =

Emergent anatomy of the thymic lobule. The circles are developing thymocytes. The figure is a snapshot of an animated simulation. Thymocytes are color-coded for each developmental stage. Emergent Anatomy

Cell Migration

Zooming into the Thymus

Experimenting in silico

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