‘ Green’ Architects ‘Green’ Builders Southeast Asia’s first ‘zero’ energy building Bradell Road, Singapore

Floor Diffusers Dimmers/ Sensors Fluorescent Lighting Photovoltaics Solar Chimney Shading Devices

The Historical ‘Toolkit’

Capability = Tools & Methods + People

The Tools & Methods Needed Sustainable Manufacturing Problem Areas –Chemical Transformations –Biotransformations –Physical Transformations –Solvent Selection and Optimization –Unit Operation Selection and Optimization –Equipment and Technology Selection –Controls Selection and Optimization –Recovery and Reuse Integration –Waste Treatment and Minimization –Lifecycle Analysis –Facilities and Supply Chain 1 st RFP, 27 Jan 10

J. Am. Chem. Soc., 2003, 125 (28), pp 8456– 8457

A/Prof Robin Chi, NTU “New Green Organocatalytic Methods for Atom-Economic Amide Synthesis” Dr Rudiyanto Gunawan, NUS “Single-step crystallisation in droplets for sustainable drug formulation processes” A/Prof. Reginald Tan, ICES & NUS “Enhanced Bioavailability through formulating amorphous forms with porous biocompatible excipients” A/Prof. Loh Kai Chee, NUS “Enhanced and sustainable biohydroxylation reactions for pharmaceutical production” Dr. Anqi Chen (ICES) “Development of cost-effective and environmentally benign amide synthesis for the manufacturing of pharmaceuticals and fine chemicals” Dr Jayasree Seayad (ICES) “Development of efficient Carbon-Carbon coupling methodology by Carbon-Hydrogen bond activation for pharmaceutical and specialty chemicals synthesis.” A/Prof Tan Choon Hong (NUS) “Flavins as Biomimetic Organocatalysts for Green Chemistry” A/Prof Li Zhi (NUS) “Enantioselective biotransformations for sustainable pharmaceutical production: enzyme discovery, engineering and synthetic application”

17 ‘green’ talents to be developed by initial projects; up to 100 over program lifetime

Next Steps 2 nd call for proposals Annual symposia Build strong industrial sponsorship Continue to grow the Green and Sustainable Manufacturing Community

Do more, feel better, live longer

Back Up Slides for Media

Amide Bond Formation: The Problem Issues: Thionyl Chloride (SOCl 2, toxic, difficult to use); excess base (wasted); impure product (need extra purification step = wasted solvent)

An illustrative route of synthesis

An illustrative route of synthesis (2)