Review of 10 years Hamid R Baradaran, M.D., PhD. Assistant Professor of Epidemiology Iran University of Medical Sciences October 2007

Review of 10 years How to register your title in Cochrane

Review of 10 years Evidence for up-to-date clinical dental practice – a review of 10 years of the Cochrane Oral Health Group 30 th -31 st May 2006, Manchester Cochrane Oral Health Group - 10 years on Own logo Review of 10 years

Cochrane Oral Health Group Include all randomised controlled trials of oral health broadly conceived to include the prevention, treatment and rehabilitation of oral, dental and craniofacial diseases and disorders

Review of 10 years Oral Health Group: Background Aug ‘96UK Base established Dec ‘96 Part-time Co-ordinator appointed Mar ‘97New reviews underway July ‘97Funding secured Feb ‘98Official opening May ’0610 year symposium

Review of 10 years Editors Bill Shaw Helen Worthington Jayne Harrison Jan Clarkson Marco Esposito Ian Needleman Paul Coulthard Valeria Marinho Anne-Marie Glenny Lee Hooper

Review of 10 years Editorial Base Staff Review Group Co-ordinator Trials Search Co-ordinator (P/T) Administrator Lecturer in Evidence Based Oral Health Care Senior Research Fellow (Jan 06)

Review of 10 years Achievements Worldwide network of 624 members from 40 countries International panel of referees Set up OHG Trials Register (approx 20,000 entries) Established handsearching programme Input into NICE, HTA, SIGN, vCOHI & ADA NIDCR award

Review of 10 years Funding Base- salaries (DoH) NIDCR Italian Government NICE DoH UK (vCOHI)

Review of 10 years NIDCR Funded Project To undertake –New reviews on treatment of oral cancer –Update/new reviews on oral care for patients with cancer First NIH funding of Cochrane Reviews Unusual to fund group totally outside US

Review of 10 years Progress of Oral Health Group

Review of 10 years Number of Reviews by Collaborative Review Groups (CRGs)

Review of 10 years Status of OHG Reviews (The Cochrane Library, Issue 2, April 2006) 52 reviews published 9 reviews out with referees 69 protocols published 14 protocols out with referees 34 titles registered

Review of 10 years Systematic review Structured process involving several steps: –Well formulated question –Comprehensive data search –Unbiased selection and abstraction process –Critical appraisal of data –Synthesis of data

Review of 10 years OHG Editorial Process Register title Prepare protocol Editorial and external review of protocol Protocol entered on Cochrane Library Identify trials Complete systematic review Peer review of systematic review Systematic review entered on Library Regularly updated

Review of 10 years Title [Intervention] for [disease] in [patients] Treating periodontal disease for preventing preterm birth in pregnant women Surgical techniques for the removal of mandibular wisdom teeth

Review of 10 years Objectives To assess the effects of treating periodontal disease in pregnant women in order to prevent preterm birth, with the primary aim of reducing fetal, infant, childhood and maternal morbidity and mortality. To compare the relative benefits and risks of different surgical techniques for removing mandibular wisdom teeth.

Review of 10 years Criteria for considering studies for this review Types of studies Types of participants Types of intervention Types of outcome measures

Review of 10 years Search methods for identification of studies Searched databases Language Unpublished studies Handsearching

Review of 10 years Methods of the review Study selection Quality assessment Data extraction Data synthesis

Review of 10 years Potential conflict of interest

Review of 10 years

Presentation objectives Provide an overview of Cochrane Collaboration Demonstrate The Cochrane Library Invite participation

Review of 10 years Cochrane Collaboration An international organisation that aims to help people make well-informed decisions about healthcare by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of health care interventions.

Review of 10 years “It is surely a great criticism of our profession that we have not organised a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomised controlled trials.” Archie Cochrane

Review of 10 years THE COCHRANE COLLABORATION

Review of 10 years Principles Collaboration Building on the enthusiasm of individuals Avoiding duplication Minimising bias

Review of 10 years Principles Keeping up to date Striving for relevance Promoting access Ensuring quality Continuity

Review of 10 years Cochrane Collaboration goals To ensure high quality, up-to-date systematic reviews are available across a broad range of health care topics To promote access to Cochrane reviews

Review of 10 years Cochrane Collaboration goals To develop an efficient, transparent organisational structure and management system for the Cochrane Collaboration To achieve sustainability of the Cochrane Collaboration

Review of 10 years Systematic review Structured process involving several steps: –Well formulated question –Comprehensive data search –Unbiased selection and abstraction process –Critical appraisal of data –Synthesis of data

Review of 10 years Cochrane Collaboration Collaborative Review Groups Fields The Consumer Network Centres Steering Group Methods Groups

Review of 10 years Cochrane Collaboration Collaborative Review Groups Fields The Consumer Network Steering Group Methods Groups Centres

Review of 10 years Cochrane Centres South African Australasian Chinese Brazilian Nordic German San Antonio Italian Iberoamerican French Dutch UK Canadian New England San Francisco

Review of 10 years Cochrane Centres Help organise and register review groups Facilitate collaboration among reviewers Provide training and consultation Establish liaisons Promote the Cochrane Collaboration Provide unique contribution

Review of 10 years Cochrane Collaboration Fields The Consumer Network Centres Steering Group Methods Groups Collaborative Review Groups

Review of 10 years Review Groups 48 registered, 1 possible Focus –Treatment of disease or health problems Emphasis on clinical outcomes Emphasis on rigorous data

Review of 10 years Review Groups Acute respiratory infections Airways Anaesthesia Back Breast cancer Colorectal cancer Consumers and communication Cystic fibrosis and genetic disorders Dementia & cognitive improvement Depression, anxiety & neurosis Developmental, psychosocial and learning problems Drugs and alcohol Ear, nose and throat disorders Effective practice and organisation of care Epilepsy Eyes and vision Fertility regulation Gynaecological cancer Heart Hepato-biliary

Review of 10 years Review Groups HIV/AIDS Hypertension Incontinence Infectious diseases Inflammatory bowel disease Injuries Lung cancer Menstrual disorders and subfertility Metabolic and endocrine disorders Movement disorders Multiple sclerosis Muskuloskeletal Musculoskeletal injuries Neonatal Neuromuscular disease Oral health Pain, palliative and supportive care Peripheral vascular diseases Pregnancy and childbirth Prostatic diseases and urologic cancers Renal Schizophrenia

Review of 10 years Review Groups Sexually transmitted diseases Skin Stroke Tobacco addiction Upper gastrointestinal and pancreatic diseases Wounds Haematological malignancies (possible)

Review of 10 years Review Group products Reviews Specialised register

Review of 10 years Review Groups Reviewers –International group –Review relevant trials on specified health care problems –Long-term commitment

Review of 10 years Collaborative Review Group process Review Group Co-ordinator Cochrane Database of Systematic Reviews Editor s Systematic Reviewer Systematic Reviewer Systematic Reviewer Systematic Reviewer Systematic Reviewer

Review of 10 years Review Manager (RevMan) Cochrane Collaboration software for: –Preparing and maintaining protocols and reviews –Data analysis –Submitting completed reviews to CDSR

Review of 10 years RevMan statistical options Peto Method –Odds Ratio Mantel-Haenszel fixed effect and Dersimonian/Laird random effects –Odds Ratio, Relative Risk, Risk Difference –Weighted and Standardised Mean Differences

Review of 10 years The Cochrane Library The Cochrane Database of Systematic Reviews (CDSR) The Database of Abstracts of Reviews of Effectiveness (DARE) The Cochrane Controlled Trials Register (CCTR) The Cochrane Methodology Register

Review of 10 years Cochrane Collaboration Collaborative Review Groups Fields The Consumer Network Centres Steering Group Methods Groups

Review of 10 years Fields 9 registered, 1 possible Represent a population, group, or type of care that overlaps multiple Review Group areas Examples: Primary Health Care, Health Care of Older Adults, Complementary Medicine, Vaccines, Rehabilitation and Related Therapies

Review of 10 years Methods Groups 11 registered, 5 possible Develop methods and products integral to internal functioning of the Collaboration Develop state of the art methods for systematic reviews Examples: Statistical Methods, Economics, Placebo Effects, Informatics

Review of 10 years The Consumer Network Provides consumer input Helps set priorities Helps with dissemination

Review of 10 years Cochrane Collaboration Collaborative Review Groups Fields The Consumer Network Centres Methods Groups Steering Group

Review of 10 years Steering Group Function –Policy making body of the Cochrane Collaboration Who –Elected representatives of each of the Collaboration entities (Review Groups, Centres, Fields, Methods Groups, the Consumer Network)

Review of 10 years Summary of The Cochrane Collaboration International collaboration Prepares, maintains, and disseminates systematic reviews Diverse internal structure (Review Groups, Centres, Fields, Methods Groups, the Consumer Network)

Review of 10 years How to participate Join a Collaborative Review Group Join a Field, Methods Group, or the Consumer Network Handsearch a journal Identify or provide funding

Review of 10 years The future...

Review of 10 years Future challenges Recruitment of large numbers of reviewers in all areas of health care Clinically useful presentation of the Cochrane Database of Systematic Reviews Efficient and effective communication within the Collaboration Financial solvency of the organisation

Review of 10 years THE COCHRANE COLLABORATION

Review of 10 years