Commercial tools for gene list analysis Boo Virk v1.0.

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Presentation transcript:

Commercial tools for gene list analysis Boo Virk v1.0

Why use commercial tools? Benefits: Each tool has their own large database Databases are updated regularly and curated All analysis can be done in one package Overlay different projects/experiments to see potential links Customer Support

Commercial tools for gene list analysis Many available – examples include:

Advaita - Only pay for reports you will publish Thomson Reuters – more focussed on human diseases and drug discovery Agilent Technologies – integrated with Ingenuity Pathway Analysis (IPA) and Metacore

Commercial tools for gene list analysis Many available – examples include:

Ingenuity Pathway Analyser (IPA®)

Top Pathways

Function Heatmap

Identify potential upstream regulators

Networks

Summary Report NOTE: IPA uses Fisher’s Exact test right tailed test – which is twice as likely to reach significance!

Analysis is no different from free tools Statistics and outputs are similar to those obtained from free web based resources £££££ Are larger databases necessarily better? Limitations of Commercial tools

Which tool to use? There are different types of software available, both free and commercial Try a few, and find the tool that’s best for your experiments and needs Using more than one tool to analyze your data may provide new insights or lend extra confidence to your results