USAMRMC – Protect the Warrior, Sustain the Force Agenda What? Who? Why? How?

USAMRMC – Protect the Warrior, Sustain the Force Program Overview: Rapid Vector Diagnostics for Military Deployments. COL Russell Coleman, CPT Elizabeth Wanja and Professor Michael Faulde The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense.

USAMRMC – Protect the Warrior, Sustain the Force Why Vector Diagnostics? Medical mission is preserve the fighting force; Threat is not the arthropods but the diseases they carry; Knowing what diseases are present and where allows for targeted vector control;

USAMRMC – Protect the Warrior, Sustain the Force

CONOPS Part of integrated effort (collect, ID arthropod, pathogen detection, control) Two-tiered System –Hand-held assays used by BCT PM staff or PVNTMED Det; –Molecular assays used by laboratory (AML, FDPMU, AF BAT, CSH, CHPPM…) Negative results minimal value, positive results tremendous value –Allow for targeted control efforts; –Get action from non-medical types;

USAMRMC – Protect the Warrior, Sustain the Force DoD Procurement 6.3 OMA A 6.4 Operations & Support Engineering & Manufacturing Development Production & Deployment Technology Development Program Initiation BC Materiel Solution Analysis Research User Needs Technology Opportunities & Resources MDD 6.7 ICD CDDICDCPD Product Development Process CAPABILITY DEVELOPMENT DOCUMENT (CDD) ARTHROPOD VECTOR RAPID DIAGNOSTIC DEVICES (AV-RDD) Increment: I ACAT: III Validation & Approval Authority: HQDA Milestone Decision Authority: CG, USAMRMC Draft Version December 2009

USAMRMC – Protect the Warrior, Sustain the Force

Fielding Plan

USAMRMC – Protect the Warrior, Sustain the Force Phased in Fielding

USAMRMC – Protect the Warrior, Sustain the Force AV-RDD Attributes

USAMRMC – Protect the Warrior, Sustain the Force Current Status of AV-RDD Malaria (falciparum and vivax): Fielded North American Arboviruses (WN, WEE, SLE, EEE): Fielded Rift Valley fever virus (Ph II SBIR):Field studies Dengue (Ph II SBIR):Lab studies Leishmaniasis (Ph II SBIR):Lab studies Sand fly fever virus (Ph II SBIR): Lab studies Tick-borne pathogen multiplex (CCHF/TBE/Rickettsia, Ph 1 SBIR): Lab studies

USAMRMC – Protect the Warrior, Sustain the Force Current Status of AV-RDD All previous and current efforts are Immuno- chromatographic wicking assays developed by Dr. Kirti Dave, currently VecTOR Test Systems; Diagnostic technology rapidly changing and could be incorporated into this program.

USAMRMC – Protect the Warrior, Sustain the Force Use of AV-RDD during Deployments Malaria VecTEST Assay widely used in Iraq and Afghanistan. –Iraq: Few anophelines, few assays run, no positives. In 2003/2004 negative data assisted in decision to remove requirement for mandatory malaria chemoprophylaxis; –Afghanistan: More anophelines, more assays run, a number of positives. Data helped shaped control programs; Comments/Thoughts???

USAMRMC – Protect the Warrior, Sustain the Force