Expanding Biomedical Research in Maine Mount Desert Island Biological Laboratory Patricia H. Hand, Ph.D. Administrative Director

Mount Desert Island Biological Laboratory 108 year old biomedical and marine research institution - oldest in state Historically a seasonal institution with scientists from 65 institutions Dramatic growth since 2000 Now have 7 full-time scientific groups employees employees Federal funding: M Operating budget: M MISSION To promote research and education in the biology of marine organisms; to foster understanding and preservation of the environment; and to advance human health.

Research 21 year history of NIH Toxicology Center funding in Environmental Health Established nation’s first Center for Marine DNA Sequencing (sequencing of the skate and sea urchin genomes) Established nation’s first Center for Marine Functional Genomic Studies Development of the Comparative Toxicogenomics Database Two companies from discoveries at MDIBL

Dramatic increase in educational programs Providing hands-on technical training to more than 300 students per year Well positioned to address Maine’s need for a technically skilled workforce Educational Programs

IDeA Network of Biomedical Research Excellence INBRE $26 M NIH grant to MDIBL to strengthen Maine’s research capacity and competitiveness Partnership between MDIBL and eight Maine institutions

IDeA: Institutional Development Award National Center for Research Resources (NCRR), National Institutes of Health (NIH) Broadens the geographic distribution of NIH funding Two main components: -Centers of Biomedical Research Excellence (COBRE) -IDeA Networks of Biomedical Research Excellence (INBRE) IDeA States

Maine IDeA Network of Biomedical Research Excellence Maine INBRE Supports… Undergraduate Student Research Training to more than 600 students over 5 years Junior Faculty Development Institutional Development Outreach

Maine IDeA Network of Biomedical Research Excellence Undergraduate Research Training Annual Short Courses Laboratory in Behavioral Neuroscience Functional Genomics of Membrane Transport Environmental Toxicogenomics Molecular Biology Research Techniques

Maine IDeA Network of Biomedical Research Excellence Undergraduate Research Training Summer Fellowships 8-10 weeks Available to students attending Maine undergraduate institutions Mentor is federally-funded established scientist

Maine IDeA Network of Biomedical Research Excellence Junior Faculty Research/Comparative Functional Genomics REPRESENTATIVE MAINE INBRE RESEARCH PROJECTS & LEADERS Clare Congdon, Ph.D., Colby College Machine Learning Methods for Phylogenetics and Genomics Joel Graber, Ph.D., The Jackson Laboratory Bioinformatics of Post-transcriptional Regulatory Elements Carolyn J. Mattingly, Ph.D., MDI Biological Laboratory Identification of Novel Regulatory Sequences in ABCB and ABCC Subfamily Genes by Comparative Genomic Analysis Antonio Planchart, Ph.D., College of the Atlantic, MDI Biological Laboratory Discovery and Characterization of Conserved Motifs that Regulate Gene Expression During Spermatogenesis Nicole J. Theodosiou, Ph.D., Bowdoin College Wnt Signaling in the Developing Gastrointestinal Tract Rebecca J. Sommer, Ph.D., Bates College Dioxin Exposure Impairs Embryonic Heart Development: Comparative Expression and Promoter Analysis of the Beta 1 - Adrenergic Receptor

Maine IDeA Network of Biomedical Research Excellence INSTITUTIONAL DEVELOPMENT According to the Needs of Each Institution Imaging Facility Technician for Core Facility or to Work with Faculty Group Student Research Fellowships: academic & summer Research Equipment Electronic Journals Meeting Travel Sponsored Program Office Development Collaborative Research Seminars/Visiting Scientists

Maine IDeA Network of Biomedical Research Excellence OUTREACH Conferences & Symposia Maine Biological and Medical Sciences Symposium Bioinformatics Workshop Seminars/Visiting Scientists Short Courses Undergraduate & Graduate Student Fellowships

Maine IDeA Network of Biomedical Research Excellence Maine INBRE Structure

Maine IDeA Network of Biomedical Research Excellence Communications Website Newsletter Quarterly Features each institution Download at the Maine INBRE website

Maine IDeA Network of Biomedical Research Excellence MEASURES OF SUCCESS Institutions good working relationship; collaborations other institutions seek to be included Junior Faculty collaborating with each other publications: 37 published, 13 in press, 4 submitted grants: 25 submitted, 13 funded, 7 pending one awarded R01 grant, independence Students increased number of science majors graduate, medical school, research jobs