Material Control & Accountability Introduction Physical Security Personnel Material Control & Accountability Transport Information Controlling Laboratory Biorisks Training Course International Biological Threat Reduction Program Global Security Programs Sandia National Laboratories Albuquerque, NM USA SAND No. 2008-0480P Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000.

Sandia National Laboratories Provides innovative, science-based, systems-engineering solutions to the most challenging national and international security problems Over 8,500 employees Over 1,500 PhDs Over 2,500 MS/MA Over 1,000 on-site contractors Annual operating budget ~$2 billion Physics 8% Other Fields 11% Engineering 14% Mechanical 15% Electrical 25% Biology 6% Computing 11% Chemistry 7% Math 3% 1,527 PhD, 2,562 MA or MS, 1,475 BA or BS, 3,034 other Total : 8,598 employees Employees’ degrees are concentrated in engineering. We currently employ ~3000 people with MS and PhD degrees in science and engineering. Our employees live and pay income taxes in ~12 states. We also have a number of employees in foreign countries—including Germany and Japan. We currently have over 1,000 contractors on site at Sandia.

Sandia’s Global Security Center Reduces current and emerging proliferation and terrorism threats by creating sustainable system solutions through international cooperation US/Russia Nuclear Security Reducing the risk of theft or diversion of Russian nuclear weapons, materials, and related expertise Border Security Detecting, deterring, and interdicting nuclear smuggling across international borders Nuclear Nonproliferation/ International Physical Security Preventing the proliferation of weapons of mass destruction by enhancing International Safeguards, and promoting the peaceful uses of nuclear technology Biological/Chemical Threat Reduction Reducing biological and chemical threats globally by focusing on safety and security of legitimate materials Regional Security Developing technical solutions to regional security problems

Sandia’s International Biological Threat Reduction IBTR’s mission: To enhance United States and international security by reducing biological threats worldwide IBTR’s highest goals Enhance safety, security, and containment of dangerous biological agents in bioscience facilities Strengthen capacities to detect and control dangerous biological agents Improve understanding and mitigation of biological threats Reduce the risk that bioscience and biotechnology could be used maliciously Illegitimate acquisition of dangerous pathogens Reckless legitimate use of dangerous pathogens

IBTR Technical Program Areas Extensive collaboration with US Government agencies Laboratory Biosafety, Biosecurity, and Biocontainment Infectious Disease Diagnostics and Control Training and Workshops Policy, Regulatory, and Guidelines Support Extensive collaboration with international organizations Assessments and Analysis

Course Overview Assessment Mitigation Performance Biorisk Management Lectures Case studies Guided class discussions Lab activities Group presentation Course assessments Pre-course assessment Daily quizzes Post-course assessment Explain the scope of the course, what it will and will not prepare you to do.

Case Studies Case studies will be done in the same small groups for the week You will complete all case studies as a member of the “Facility Biorisk Committee” Biorisk officer Laboratory manager Principal investigator Facilities, operations & maintenance representative Through the series of case studies, the “Facility Biorisk Committee” is tasked with doing a risk assessment and developing a risk mitigation plan On Day 5, your “Facility Biorisk Committee” will present your risk assessment and risk mitigation plan

Pre-Course Test

Report your answers to the class. Group Exercise #1 In your group take 10 minutes to discuss and answer the following question: What are the risks of working in a laboratory with biological materials? Report your answers to the class.

Group Exercise #2 In your group, take 10 minutes to discuss and answer the following three questions: How did you identify these risks? Which steps do you take to minimize these risks? How do you know these steps are working? Use post-it notes to write down your answers and post them on the empty board.

Group Exercise #3 Let’s get organized… Take the post-it notes and place them under one of the following columns: Assessment Mitigation Performance

Biorisk The risk associated with biological materials in the laboratory has a safety and a security component. The concept of Biorisks encompasses both Biosafety and Biosecurity.

What are Laboratory Biosafety and Biosecurity? Biosafety Risk The risk of accidental exposure to or release of a biological hazard Biosecurity Risk The risk of intentional removal (theft) of a valuable biological material How do we best manage these Biorisks? Francisella tularensis Yersinia pestis

Key Components of Biorisk Management Biorisk Management has three key components: Risk Assessment Risk Mitigation Performance / Quality Control

Biorisk Management: The AMP Model Assessment Mitigation Performance Hazard ID Risk Assessment Biorisk Control Measures Risk Management Processes QA/QC Objectives

Next Steps… During the next sessions we will refer back to the AMP model and individually address the three components