SCALABLE PRODUCTION OF POLYMERIC NANOPARTICLES YING LIU ASSISTANT PROFESSOR DEPARTMENT OF CHEMICAL ENGINEERING DEPARTMENT OF BIOPHARMACEUTICAL SCIENCES UNIVERSITY OF ILLINOIS AT CHICAGO

NANOPARTICLES FOR DRUG DELIVERY  Increase hydrophobic compound solubility and bioavailability Rate   A i (C sat - C bulk )  Targeting drug delivery Passive targeting tumors (EPR) Functional surfaces PEG: bio-inert, long circulating PAA: mucoadhesive PEG-ligand: active targeting  Protection from degradation  Sustained drug release Nanoparticle stabilized with block copolymers

Reproducible, large scale production of particles with controlled properties  Formation  Stability  Application Research in laboratories Clinical application HOW TO GET THERE?

FLASH PRECIPITATION AND DRY PROCESS  Scalable and continuous process  Long-term stability  Enhanced oral bio-availability (>1000 compared to the pure drug and >10 compared to the Labrasol®)  >50% drug loading  controlled size distribution and surface properties

INCREASED BIOAVAILABILITY AND FUNCTIONALITY SR13668 Bioavailability in dogs Curcumin for attenuating morphine tolerance and dependence using mouse model

ADVANTAGES OF THE MICROSCALE DAVID EDDINGTON ASSISTANT PROFESSOR DEPARTMENT OF BIOENGINEERING MICROFLUIDICS AND DIAGNOSTICS UNIVERSITY OF ILLINOIS AT CHICAGO

Rapid Diffusion Large surface to volume ratio Laminar flow Process integration ADVANTAGES OF THE MICROSCALE Mohammed et al, 2009, Lab on a Chip Brett et al, 2012, Lab on a Chip Sinkala et al, 2012, Lab on a Chip Launiere et al, 2012, Analytical Chemistry

Current Tools: Hypoxic Chambers Crude, inefficient, and problematic Cannot replicate gradients of oxygen found across all tissues in every animal Microfluidic devices can control oxygen over many levels Cells (multiwell plate and open-well) Tissues (islets and brain slices) Animals (wound healing) OXYGEN IS A KEY METABOLIC VARIABLE

FUNCTIONAL ASSAY FOR ISLETS

HIGH VS LOW POTENCY ISLETS 1000 human islets transplanted into nude mice Our device can evaluate islet tissue better than standard methods Standard evaluation shows no difference in function Gold standard = 30 day mouse transplantation model Quick, but poor predictor Predicts outcome, but only in retrospect

POWER CONVERTERS MAHSHID AMIRABADI ASSISTANT PROFESSOR DEPARTMENT OF ELECTRICAL & COMPUTER ENGINEERING POWER ELECTRONICS, RENEWABLE ENERGY SYSTEMS, ELECTRIC AND HYBRID ELECTRIC VEHICLES, AC DRIVES UNIVERSITY OF ILLINOIS AT CHICAGO

POWER CONVERTERS  Power converters control and process the flow of electrical energy.  These circuits are integral part of many systems including, but not limited to, renewable energy systems and electric and hybrid electric vehicles.  Power Electronics is an Enabling Technology.