European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership 19 July 2011 IAS 2011 Rome, Italy Charles S Mgone EDCTP Executive Director.

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Presentation transcript:

European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership 19 July 2011 IAS 2011 Rome, Italy Charles S Mgone EDCTP Executive Director

About EDCTP Partnership between European member states, European Commission and Africa in collaboration with like minded organisations in fighting diseases of poverty – HIV/AIDS, malaria and tuberculosis This is realised by funding clinical trials and research capacity to accelerate development of intervention tools including drugs, vaccines, microbicides and diagnostics against these diseases

The partnership Benin Botswana Burkina Faso Cameroon Congo Cote d’Ivoire Democratic Republic of Congo Ethiopia Gabon Ghana Guinea Guinea-Bissau Guinea-Conakry Kenya Liberia Madagascar Malawi Mali Mozambique Namibia Nigeria Rwanda Senegal South Africa Sudan Tanzania The Gambia Togo Uganda Zambia Zimbabwe Austria Belgium Denmark France Germany Greece Ireland Italy Luxembourg Netherlands Norway Portugal Spain Sweden Switzerland United Kingdom EDCTP-EEIG member states Sub-Saharan African countries

Strengthening of clinical trials capacity and the enabling environment

EDCTP Regional Networks for Clinical Trials Western Africa: WANETAM Website: Project Coordinator: Prof. Soleymane Mboup Burkina Faso The Gambia Ghana Guinea-Bissau Mali Nigeria Senegal United States Southern Africa: TESA Website: Project Coordinator: Dr Alexander Pym Botswana Malawi Mozambique South Africa Zambia Zimbabwe France Germany Netherlands United Kingdom Eastern Africa: EACCR Website: Project Coordinator: Dr Pontiano Kaleebu Kenya Sudan Ethiopia Tanzania Uganda Germany Sweden United Kingdom United States Central Africa: CANTAM Website: Project Coordinator: Prof. Francine Ntoumi Cameroon Congo, Republic of the Gabon France Germany

Funded projects including clinical trials Treatments 13 Vaccines9 Microbicides4 HIV/AIDS 26 clinical trials M € Treatments7 Vaccines7 Diagnostics4 Tuberculosis 18 clinical trials M € Treatments 10 Vaccines 2 Malaria 12 clinical trials M € EDCTP has funded 174 projects in 29 African countries including 56 clinical trials on HIV/AIDS, malaria and TB

HIV/AIDS treatment and prevention trials Evaluation of paediatric formulations: fixed drug combinations/scored dispersible tablets Evaluation of second-line treatment HIV/TB co-infections Prevention of Mother to Child Transmission of HIV (PMTCT)

HIV preventive vaccine trials Capacity building in preparation for HIV vaccine trials- Joint EDCTP/BMGF grant DNA+MVA-CMDR (rgp 140/GLA-AF) phase I/II clinical trial (TaMoVac + AfrEVacc) in healthy young adults DNA + MVA-HIVA phase I/II in healthy infants born to HIV1 and HIV2 uninfected and infected mothers

Microbicide trials Site preparation/capacity strengthening Establishment of cohorts Characterisation of novel safety markers PRO 2000 vaginal gel phase III clinical trial

EDCTP-II Consolidation of the current focus on clinical trials Phase II and III clinical trials Expansion to phase I and IV clinical trials Health services/optimisation studies Neglected Tropical Diseases including co-morbidities Open collaborative projects with other developing countries beyond sub-Saharan Africa

Thank you