Muhammad Adeel Faiza Asghar Amina Shakarullah

What is Regenerative Medicine? Adeel What is the Current Perspectives and Therapeutic Potential of Regenerative Medicine? Amina A case study of Regenerative Medicine. Faiza

A personalized form of medicine. It is the process of replacing or regenerating human cells, tissues or organs to restore or establish normal function.

How do cells know into what tissue they are to mature? How do tissues maintain their structural and functional identity? How do tissues coordinate their activities within the body? Why can some tissues regenerate and not others? Why can human fetuses regenerate limbs? Why do newborn babies rarely scar?

Genes Growth Factors

Autologous Therapies (Patient’s own cells) Eg. Stem cells for liver cirrohsis Heart tissue repair (London, on-going clinical trial-initial testing positive) Allogenic Therapies (cells from other sources) Eg. London Project to cure blindness Tissue Engineering (modifying cells) Eg. Claudia’s trachea Biomedical Engineering (biomedical device mimicing tissue/organ) Eg. Artificial Pancreas

Heparan sulfate analogues are polymers engineered to mimic several properties of heparan sulfates. Heparan sulfates can sequester growth factors (GFs) and cytokines in the extracellular matrix(ECM) thereby protecting them from degradation. However, at any site of inflammation, so also in wound areas, heparan sulfates are degraded, mainly by heparanases giving free access to protease to degrade the ECM and a subsequent loss of GFs and cytokines that disrupts the normal tissue homeostasis.

Heparan sulfate analogues are resistant to enzymatic reaction. This way they strengthen the healing potential of the wound bed by repositioning GFs and cytokines back into the ECM.

A biomaterial is any material, natural or man-made, that comprises whole or part of a living structure or biomedical device which performs, auguments, or replaces a natural function.