Geometry of Carriers Controlling Phenotypic Expression in BMP-Induced Osteogenesis and Chondrogenesis by Yoshinori Kuboki, Qiming Jin, and Hiroko Takita.

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Presentation transcript:

Geometry of Carriers Controlling Phenotypic Expression in BMP-Induced Osteogenesis and Chondrogenesis by Yoshinori Kuboki, Qiming Jin, and Hiroko Takita J Bone Joint Surg Am Volume 83(1 suppl 2):S105-S115 April 1, 2001 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 Apparatus for the preparation of honeycomb hydroxyapatite (A) and its products (B and C). Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 Apparatus for the preparation of honeycomb hydroxyapatite (A) and its products (B and C). Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 Apparatus for the preparation of honeycomb hydroxyapatite (A) and its products (B and C). Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 2 Geometry-directed cartilage and bone formation in honeycomb hydroxyapatite (HCHAP) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) in the smaller diameter tunnel ( m). Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 3 Geometry-directed cartilage and bone formation in honeycomb hydroxyapatite (HCHAP) combined with recombinant human bone morphogenetic protein (rhBMP-2) in the larger diameter tunnel (350 m). Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 4 Schematic representation of geometry-directed chondrogenesis and osteogenesis in the honeycomb hydroxyapatite with larger (A) and smaller (B) tunnels, which are applied as bone morphogenetic protein (BMP) carriers. Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 4 Schematic representation of geometry-directed chondrogenesis and osteogenesis in the honeycomb hydroxyapatite with larger (A) and smaller (B) tunnels, which are applied as bone morphogenetic protein (BMP) carriers. Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 5 Alkaline phosphatase activity (A) and osteocalcin contents (B) of implants of bone morphogenetic protein combined with porous blocks of hydroxyapatite of different pore sizes. Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 5 Alkaline phosphatase activity (A) and osteocalcin contents (B) of implants of bone morphogenetic protein combined with porous blocks of hydroxyapatite of different pore sizes. Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 6 Microphotographs of cross sections of bone morphogenetic protein (BMP)-combined porous blocks of hydroxyapatite 4 weeks after implantation. Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.

Classification of geometry in extracellular matrices. Yoshinori Kuboki et al. J Bone Joint Surg Am 2001;83:S105-S115 ©2001 by The Journal of Bone and Joint Surgery, Inc.