Uncomplicated – Major regimen Uncomplicated – Major regimen Complicated (Spondylitis, neurobrucellosis, or endocarditis) Complicated (Spondylitis, neurobrucellosis,

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Presentation transcript:

Uncomplicated – Major regimen Uncomplicated – Major regimen Complicated (Spondylitis, neurobrucellosis, or endocarditis) Complicated (Spondylitis, neurobrucellosis, or endocarditis) Pregnant women Children Uncomplicated – Alternative Uncomplicated – Alternative منوی اصلی | رژیم اصلی | رژیم آلترناتیو | عارضه دار | حاملگی | کودکان | فرم های دارویی

Uncomplicated Doxycycline 100 mg twice daily = for 6 weeks, Streptomycin 1 gr IM Daily = for 2-3 weeks Doxycycline 100 mg twice daily = for 6 weeks, Rifampin mg PO once Daily = for 6 weeks Rx: Doxycycline Cap. 100 mg # 84 Bid Streptomycin Vial 1 gr # IM, qd Rx: Doxycycline Cap. 100 mg # 84 Bid Rifampin Cap. 300 mg # 126 Tid or 3 Cap once daily Rifampin Cap. 150 mg # Cap. Tid or 6 Cap once daily منوی اصلی | رژیم اصلی | رژیم آلترناتیو | عارضه دار | حاملگی | کودکان | فرم های دارویی

Alternative Resistance, toxicity or relapse Alternative Resistance, toxicity or relapse Fluoroquinolones : Ciprofloxacin 500 mg PO q12h or Ofloxacin 200 mg PO q12h Plus Doxycycline 100 mg twice daily = for 6 weeks or Rifampin mg PO once Daily = for 6 weeks منوی اصلی | رژیم اصلی | رژیم آلترناتیو | عارضه دار | حاملگی | کودکان | فرم های دارویی

Pregnant women Rifampin ( 900 mg QD ) ± Cotrimoxazole ( AdultTab q12h ) For 6 weeks بجز در ماه آخر که کوتریموکسازول ممنوعیت دارد. در ماه آخر بارداری، مصرف کوتریموکسازول، خطر کرنیکتروس را زیاد می کند. منوی اصلی | رژیم اصلی | رژیم آلترناتیو | عارضه دار | حاملگی | کودکان | فرم های دارویی

Children Age < 8 yr : For 4-6 weeks Cotrimoxazole + Rifampin Age ≥ 8 yr : For 6 weeks Doxycycline + Rifampin IF osteoarticular, neurobrucellosis, or endocarditis : At least 6 weeks ( up to 6 months for life-threatening ) < 8 years : Cotrimoxazole 6 wks + Parentral AG for first 2 wks + Rifampin ≥ 8 years : Doxycycline for 6 wks + Parentral AG for first 2 wks + Rifampin منوی اصلی | رژیم اصلی | رژیم آلترناتیو | عارضه دار | حاملگی | کودکان | فرم های دارویی

Spondilitis: At least 12 weeks ( 3 months) Doxycyclin plus Streptomycin is better Endocarditis: Triple therapy + Cardiosurgery Consult Duration : 3-6 months Doxycycline + Rifampin + Cotrimoxazole or AG Neurobrucellosis: Triple therapy Doxycycline + Rifampin + Ceftriaxone ( Shorter duration )or Doxycycline + Rifampin + Cotrimoxazole Duration : Until CSF clearance منوی اصلی | رژیم اصلی | رژیم آلترناتیو | عارضه دار | حاملگی | کودکان | فرم های دارویی

ریفامپین : کپسول 150 کپسول 300 کوتریموکسازول : قرص بزرگسال SMX 400/TMP 80 قرص کودک SMX 100/TMP 200 شربت SMX 200/TMP 40 / 5 ml ویال SMX 400/ TMP 80 استرپتومایسین : ویال 1 گرم داکسی سیکلین : قرص 100 کپسول 100 جنتامایسین : ویال 20 ویال 40 ویال 80 منوی اصلی | رژیم اصلی | رژیم آلترناتیو | عارضه دار | حاملگی | کودکان | فرم های دارویی