Development of Harvard Catalyst Imaging Consultation Service Simon K. Warfield, Ph.D. Valerie Humblet, Ph.D. on behalf of the CTSC Imaging Committee

Outline 1 Harvard Catalyst Imaging Consortium Technology effort: Inter-site data exchange Why be a consultant ? Contact

Harvard Catalyst: The Basics 2 We are a cross-Harvard enterprise dedicated to improving human health by: –Creating Connections –Enabling research At the Cutting Edge of discovery –Nurturing clinical and translational researchers

National Effort in C/T Research 3 Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium Source:

Institutions participating in Harvard CTSC 4 Hospitals and Institutes Beth Israel-Deaconess Medical Center Brigham and Women’s Hospital Massachusetts General Hospital Children’s Hospital Boston Dana-Farber Cancer Institute Forsyth Dental Institute Joslin Diabetes Center Massachusetts Eye and Ear Infirmary McLean Hospital Schepens Eye Research Institute Massachusetts Institute of Technology Harvard University Faculty of Arts and Sciences Harvard Business School Harvard School of Dental Medicine Harvard Divinity School Graduate School of Design Graduate School of Education Kennedy School of Government Harvard Law School Harvard Medical School Harvard School of Public Health Harvard School of Engineering Community Healthcare Institutions Cambridge Health Alliance HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare

Mission of the Imaging Consortium 5 Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment.

Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Imaging Consortium Team 6

XNAT Enterprise Data Repository (CRC) File Repository Identity Management Ontology Management Correlation Analysis De - Identification Of data Natural Language Processing Annotating Genomic Data #1 Project Management Workflow Framework Annotating Genomic Data #2 PACS i2b2 HIVE Dr X Desktop Pediatric rare disease Dr Y Desktop Alzheimer Dr Z Desktop Chronic pain management Dr W Desktop Quantitative cancer biomarkers Inter-site data exchange 7

Becoming an Imaging Consultant 8 Potential benefits of volunteering to be a consultant: –Networking leading to collaborations and funding (eg: pilot grants) –Increase user base of service –Mentoring new investigators

Radiology at Children’s Hospital Expertise in Pediatric Imaging Image analysis algorithms especially suited to pediatrics Software implementation supported by NIH to create a platform for scientific discovery: –Computational Radiology Kit (CRKit) –Open source software 9

Radiology at Children’s Hospital Computational Radiology Kit (CRKit) –Pediatric MRI image segmentation –Intra-subject multi-modality image fusion –Inter-subject alignment Neuroimage atlasing Diffusion tensor image group analysis for RCT –Tractography –Visualization –Validation for quantitative image analysis 10

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