EXERCISES POP QUIZ POOLING LOGISTIC REGRESSION. POP QUIZ.

Slides:



Advertisements
Similar presentations
1 Matching EPIET introductory course Mahón, 2011.
Advertisements

More than two groups: ANOVA and Chi-square. First, recent news… RESEARCHERS FOUND A NINE- FOLD INCREASE IN THE RISK OF DEVELOPING PARKINSON'S IN INDIVIDUALS.
Matching in Case-Control Designs EPID 712 Lecture 13 02/23/00 Megan O’Brien.
Two-sample tests. Binary or categorical outcomes (proportions) Outcome Variable Are the observations correlated?Alternative to the chi- square test if.
M2 Medical Epidemiology
1 Arlene Ash QMC - Third Tuesday September 21, 2010 (as amended, Sept 23) Analyzing Observational Data: Focus on Propensity Scores.
Comparing Exponential and Linear Functions Lesson 3.2.
Matched designs Need Matched analysis. Incorrect unmatched analysis. cc cc exp,exact Proportion | Exposed Unexposed | Total Exposed
Random error, Confidence intervals and p-values Simon Thornley Simon Thornley.
Multiple Logistic Regression RSQUARE, LACKFIT, SELECTION, and interactions.
Measures of Disease Association Measuring occurrence of new outcome events can be an aim by itself, but usually we want to look at the relationship between.
Measures of association
Risk and Relative Risk. Suppose a news article claimed that drinking coffee doubled your risk of developing a certain disease. Assume the statistic was.
Introduction to Logistic Regression. Simple linear regression Table 1 Age and systolic blood pressure (SBP) among 33 adult women.
Notes on Logistic Regression STAT 4330/8330. Introduction Previously, you learned about odds ratios (OR’s). We now transition and begin discussion of.
Basic Statistics for Research: Choosing Appropriate Analyses and Using SPSS Dr. Beth A. Bailey Dr. Tiejian Wu Department of Family Medicine.
Case-Control Studies. Feature of Case-control Studies 1. Directionality Outcome to exposure 2. Timing Retrospective for exposure, but case- ascertainment.
Calculating sample size for a case-control study
Logistic Regression In logistic regression the outcome variable is binary, and the purpose of the analysis is to assess the effects of multiple explanatory.
Marshall University School of Medicine Department of Biochemistry and Microbiology BMS 617 Lecture 12: Multiple and Logistic Regression Marshall University.
Conditional Logistic Regression for Matched Data HRP /25/04 reading: Agresti chapter 9.2.
Analytic Epidemiology
Chapter 12 Correlation and Regression Part III: Additional Hypothesis Tests Renee R. Ha, Ph.D. James C. Ha, Ph.D Integrative Statistics for the Social.
ANALYSIS OF VARIANCE. Analysis of variance ◦ A One-way Analysis Of Variance Is A Way To Test The Equality Of Three Or More Means At One Time By Using.
Logistic Regression. Outline Review of simple and multiple regressionReview of simple and multiple regression Simple Logistic RegressionSimple Logistic.
Analysis of Categorical Data
Logistic Regression III: Advanced topics Conditional Logistic Regression for Matched Data Conditional Logistic Regression for Matched Data.
Biostatistics Case Studies 2005 Peter D. Christenson Biostatistician Session 4: Taking Risks and Playing the Odds: OR vs.
Hypothesis Testing Field Epidemiology. Hypothesis Hypothesis testing is conducted in etiologic study designs such as the case-control or cohort as well.
Copyright © 2010, 2007, 2004 Pearson Education, Inc. All Rights Reserved Section 10-5 Multiple Regression.
Analysis of matched data HRP /02/04 Chapter 9 Agresti – read sections 9.1 and 9.2.
Aim: How do we compute the coefficients of determination and the standard error of estimate?
AN INTRODUCTION TO LOGISTIC REGRESSION ENI SUMARMININGSIH, SSI, MM PROGRAM STUDI STATISTIKA JURUSAN MATEMATIKA UNIVERSITAS BRAWIJAYA.
Linear vs. Logistic Regression Log has a slightly better ability to represent the data Dichotomous Prefer Don’t Prefer Linear vs. Logistic Regression.
April 4 Logistic Regression –Lee Chapter 9 –Cody and Smith 9:F.
Assessing Binary Outcomes: Logistic Regression Peter T. Donnan Professor of Epidemiology and Biostatistics Statistics for Health Research.
1 Chapter 1: Stratified Data Analysis 1.1 Introduction 1.2 Examining Associations among Variables 1.3 Recursive Partitioning 1.4 Introduction to Logistic.
Analysis of Qualitative Data Dr Azmi Mohd Tamil Dept of Community Health Universiti Kebangsaan Malaysia FK6163.
Logistic Regression Applications Hu Lunchao. 2 Contents 1 1 What Is Logistic Regression? 2 2 Modeling Categorical Responses 3 3 Modeling Ordinal Variables.
1 EPI 5240: Introduction to Epidemiology Measures used to compare groups October 5, 2009 Dr. N. Birkett, Department of Epidemiology & Community Medicine,
1 Chapter 2: Logistic Regression and Correspondence Analysis 2.1 Fitting Ordinal Logistic Regression Models 2.2 Fitting Nominal Logistic Regression Models.
Matching (in case control studies) James Stuart, Fernando Simón EPIET Dublin, 2006.
Analysis of Case Control Studies E – exposure to asbestos D – disease: bladder cancer S – strata: smoking status.
Case Control Study : Analysis. Odds and Probability.
11/20091 EPI 5240: Introduction to Epidemiology Confounding: concepts and general approaches November 9, 2009 Dr. N. Birkett, Department of Epidemiology.
Logistic Regression. Linear Regression Purchases vs. Income.
1 Chapter 16 logistic Regression Analysis. 2 Content Logistic regression Conditional logistic regression Application.
1 G Lect 7a G Lecture 7a Comparing proportions from independent samples Analysis of matched samples Small samples and 2  2 Tables Strength.
More Contingency Tables & Paired Categorical Data Lecture 8.
7.1: Simplifying Rational Expressions March 31, 2009.
Logistic Regression. Linear regression – numerical response Logistic regression – binary categorical response eg. has the disease, or unaffected by the.
A first order model with one binary and one quantitative predictor variable.
1 Say good things, think good thoughts, and do good deeds.
Probability and odds Suppose we a frequency distribution for the variable “TB status” The probability of an individual having TB is frequencyRelative.
THE CHI-SQUARE TEST BACKGROUND AND NEED OF THE TEST Data collected in the field of medicine is often qualitative. --- For example, the presence or absence.
Analysis of matched data Analysis of matched data.
Additional Regression techniques Scott Harris October 2009.
Logistic Regression Logistic Regression - Binary Response variable and numeric and/or categorical explanatory variable(s) –Goal: Model the probability.
Chapter 4 Selected Nonparemetric Techniques: PARAMETRIC VS. NONPARAMETRIC.
Marshall University School of Medicine Department of Biochemistry and Microbiology BMS 617 Lecture 13: Multiple, Logistic and Proportional Hazards Regression.
Chapter 13 LOGISTIC REGRESSION. Set of independent variables Categorical outcome measure, generally dichotomous.
BINARY LOGISTIC REGRESSION
Notes on Logistic Regression
Comparing Exponential and Linear Functions
Epidemiology 503 Confounding.
Logistic regression One of the most common types of modeling in the biomedical literature Especially case-control studies Used when the outcome is binary.
Lecture 13: Case-control studies: introduction to matching
Comparing Fractions Name: ______________________________
Case-control studies: statistics
Effect Modifiers.
Presentation transcript:

EXERCISES POP QUIZ POOLING LOGISTIC REGRESSION

POP QUIZ

Exercises on Pooling Exchangeable Matched Strata

Exercises on Logistic Regression For Matched Data

Answers to Exercises on Pooling Exchangeable Matched Sets 1. How many concordant pairs are there where both pair members are exposed? «1» 2. How many concordant pairs are there where both members are unexposed? «1» 3. How many discordant pairs are there where the case is exposed and the control is unexposed? «2» 4. How many discordant pairs are there where case is unexposed and the control is exposed? «1» 5. This table is called «McNemar's» table. 6. What is the estimated mOR for these data? «2» 7. What type of matched analysis is being used with this table? «unpooled» 8. What is the estimated mOR from these data (use the formula for the mOR in the box below)? «2.5» 9. What type of matched analysis is being used here? «pooled» 10. Which type of analysis should be preferred for these matched data (where smoking status is the only matched variable), pooled or unpooled? «pooled» 11. W= «2»? 12. X = «1»? 13. Y =«0»? 14. Z= «2»? 15. mOR (unpooled) = «undefined». 16. mOR (pooled) = «2.5». 17. Which of the following helps explain why the pooled mOR estimate should be preferred to the unpooled mOR? a. The pooled mOR's are equal whereas the unpooled mOR's are different. b.The unpooled mOR's assume that exchangeable matched pairs are not unique. c.The pooled mOR's assume that exchangeable matched pairs are unique. «a»

Answers to Exercises on Logistic Regression for Matched Data 1. Which of the logistic models shown below is appropriate for analyzing these data? «b» 2. What method of estimation should be used to fit the appropriate model for these data? «Conditional MLE» 3. What is the adjusted odds ratio for the effect of SMK on cervical cancer outcome? «exp(1.4361)» 4. Is number of lifetime sexual partners a significant predictor of cervical cancer outcome, controlling for the matching variables and the other non-matching variables? «yes» 5. Are the matching variables being controlled? «yes» 6. A 95% CI for the (adjusted) effect of SMK is given by the expression «exp[ (.3167)]»