What is the current status of AIDS World Wide? Meagan Munson

What is AIDS H.I.V. H.I.V. A. I. D. S. A. I. D. S. Cell-mediated immunity Cell-mediated immunity Opportunistic infection Opportunistic infection

Tests CD4 cell count CD4 cell count Viral Load Viral Load

A Model of HIV

Transmission

Symptoms and Signs Beginning symptoms Beginning symptoms Fevers Fevers Weight loss Weight loss Swollen glands Swollen glands Progression of symptoms as CD4 cells diminish Progression of symptoms as CD4 cells diminish Herpes Herpes Tuberculosis Tuberculosis

History Co-discoverer Co-discoverer

Global Statistics

Global Demographics

U.S. Statistics White less than 2,000 White less than 2,000 Yellow 2,000-5,999 Yellow 2,000-5,999 Orange 6,000-16,000 Orange 6,000-16,000 Red 16,000 + Red 16,000 +

State by State U.S. 902,223 U.S. 902,223 Top 5 New York 162,446 New York 162,446 California 133,292 California 133,292 Florida 94,725 Florida 94,725 Texas 62,983 Texas 62,983 New Jersey 46,703 New Jersey 46,703

Who? By Exposure Men who have sex with men 46% Men who have sex with men 46% Injection Drug use 25% Injection Drug use 25% Men who have sex with men and use injection drugs 25% Men who have sex with men and use injection drugs 25% Heterosexual contact 11% Heterosexual contact 11% Blood/ tissue transfusion Blood/ tissue transfusion Not reported 10% Not reported 10% By Sex Males 81.6 % Males 81.6 % Females 18.4% Females 18.4% By Race White 42.2% Black 40.6% Hispanic 15.9% Asian 0.8% American Indian 0.3% Unknown 0.2%

Treatment Nucleoside reverse transcriptase inhibitors Nucleoside reverse transcriptase inhibitors Nucleoside reverse transcriptase inhibitors Nucleoside reverse transcriptase inhibitors Zidovudine March 19, 1987 Zidovudine March 19, 1987 Didanosine October 9, 1991 Didanosine October 9, 1991 Emtricitabine August 2, 2004 Emtricitabine August 2, 2004 Non-Nucleoside reverse transcriptase inhibitors Non-Nucleoside reverse transcriptase inhibitors Non-Nucleoside reverse transcriptase inhibitors Non-Nucleoside reverse transcriptase inhibitors Nevirapine June 21, 1996 Nevirapine June 21, 1996 Efavirenz September 17, 1998 Efavirenz September 17, 1998 Protease inhibitors Protease inhibitors Protease inhibitors Protease inhibitors Tipranavir June 22, 2005 Tipranavir June 22, 2005 Atazanavir June 20, 2003 Atazanavir June 20, 2003

Treatment cont Entry inhibitors Entry inhibitors Entry inhibitors Entry inhibitors-Fuzeon Integrase inhibitors Integrase inhibitors Integrase inhibitors Integrase inhibitors Vaccine - Is it possible? Vaccine - Is it possible? Vaccine

NRTI’s and PI’s

AZT the first approved antiretroviral drug for treatment of HIV and AIDS the first approved antiretroviral drug for treatment of HIV and AIDS FDA approved March 1987 FDA approved March 1987

Credits “HIV Cell”. graphic. 26 June DrugDevelopment-technology.com. SPG Media. 28 October 2005 “HIV Cell”. graphic. 26 June DrugDevelopment-technology.com. SPG Media. 28 October “AIDS:Definition”, 11 October MedlinePlus 20 October Biel-Cummingham, Sarah “Understanding Your Labs”. October The Body. 13 October National Institutes of Health, “Replication cycleHIV”. Graphics. November National Institute of Allergy and Infectious Disease. 28 October 2005 National Institutes of Health, “Replication cycleHIV”. Graphics. November National Institute of Allergy and Infectious Disease. 28 October 2005 ADAM, “Transmission”. Graphics. 12 August MedlinePlus. 20 October “AIDS:Signs and Tests”, 11 October MedlinePlus, 20 October ADAM, “Kaposi's sarcoma- foot”. Photo. 17 January MedlinePlus. 20 October 2005 ADAM, “Kaposi's sarcoma- foot”. Photo. 17 January MedlinePlus. 20 October 2005 ADAM, “Canker sore (aphthous ulcer)” photo. 17 January MedlinePlus. 20 October 2005 ADAM, “Canker sore (aphthous ulcer)” photo. 17 January MedlinePlus. 20 October 2005 ADAM, “Molluscum on the chest” photo. 17 January MedlinePlus. 20 October Avert, “AZT”. Photo. 29 September Avert.Org. 20 October Avert, “Nucleoside Analogs”. Photo. 29 September Avert.Org. 20 October 2005 Avert, “Nucleoside Analogs”. Photo. 29 September Avert.Org. 20 October 2005 Avert, “Protease Inhibitors”. Photo. 29 September Avert.Org. 20 October 2005 Avert, “Protease Inhibitors”. Photo. 29 September Avert.Org. 20 October 2005

Credits con’t Institute of Human Virology, “Dr. Gallo”. Photo. Institute of Human Virology. University of Maryland. 30 October UNAIDS, “Regional HIV and AIDS statitics”. Graph. December TheBody.com. World Health Organization. 15 October UNAIDS, “Global Summary”. Graph. December TheBody.com. World Health Organization. 15 October UNAIDS, “About 14,000…”. Graph. December TheBody.com. World Health Organization. 15 October Kaiser Family, “Cumulative numbers of AIDS cases”. Graph. December StateHelathFacts.org. Thebody.com 15 October 2005 Kaiser Family, “Cumulative numbers of AIDS cases”. Graph. December StateHelathFacts.org. Thebody.com 15 October 2005 Kaiser Family, “Cumulative numbers of AIDS cases by exposure”. Graph. December StateHelathFacts.org. Thebody.com 15 October 2005 Kaiser Family, “Cumulative numbers of AIDS cases by exposure”. Graph. December StateHelathFacts.org. Thebody.com 15 October 2005 U.S. Department of Health and Human Services, “Approved Mediacation to Treat HIV Infection”. September AIDSInfo. 13 October 2005 U.S. Department of Health and Human Services, “Approved Mediacation to Treat HIV Infection”. September AIDSInfo. 13 October 2005 Lonny Shavelson, “at rest”. Photo. Photowords.com. 30 October 2005 <