Algorithms Organization Ross Whitaker – Utah Polina Golland – MIT (Kayhan B.) Guido Gerig – Utah Martin Styner – UNC Allen Tannenbaum – Georgia Tech.

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Presentation transcript:

Algorithms Organization Ross Whitaker – Utah Polina Golland – MIT (Kayhan B.) Guido Gerig – Utah Martin Styner – UNC Allen Tannenbaum – Georgia Tech

Presentations Highlights from the 10-year project Recent advances Clinical/biomedical impact

Diffusion Tensor Imaging Structure, function, connectivity, and schizophrenia o Shenton/Harvard o Potkin/Irvine Technical challenges o Data preprocessing o Robust tools for analysis

DTI Technical Development Denoising o Basu, et al., MICCAI, 2006 Susceptibility artifacts o Tao, et al., IPMI 2009 Segmentation o Fletcher et al., IPMI, 2007

DTI Segmentation Volumetric tractography Volumetric paths between ROIs o A collection of shortest paths o User interaction, visualization, GPU implementations

NA-MIC DTI Analysis Ancillary grant: Lainhart/Fletcher – DTI analysis in autism o Scientific results –Arcuate fasciculus in autism, Fletcher et al, Neuroimage, –Longitudinal Heschl's gyrus in autism, Prigge et al., o Software pipeline Broader impact –Cardenas et al., J Neuroimaging, (UCSF)

Statistical Shape Modeling DBPs o Shenton/Schizophrenia o Piven/Autism o MacLeod/Marrouche Robust, general methods for shape analysis Software o ShapeWorks

Technology for Shape Analysis Correspondence/parameterization Hypothesis testing Regression Longitudinal analysis Scientific results o Harris et al., J. of Ortho. Res., 2013 o Jones et al., J. of Ortho. Res., 2013

NA-MIC Ancillary Grant Anderson: shape analysis in hip pathoanatomy (ongoing) o Shape analysis in hip biomechanics o Diagnosis and treatment planning o Database of parameterized hip models

Segmentation DBPs o Sharp/Chen, Head and Neck Cancer o MacLeod/Marrouche, Afib Robust tools for “difficult” segmentation problems o Low SNR o High shape variability

Bayesian Formulation of LA Segmentation (DCE-MRI)

LA Segmentation Results

Slicer Module