CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms.

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Presentation transcript:

CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition by Michael S. von Bergwelt-Baildon, Alexey Popov, Tomo Saric, Jens Chemnitz, Sabine Classen, Marc S. Stoffel, Francesca Fiore, Udo Roth, Marc Beyer, Svenja Debey, Claudia Wickenhauser, Franz-Georg Hanisch, and Joachim L. Schultze Blood Volume 108(1): July 1, 2006 ©2006 by American Society of Hematology

Addition of PGE2 to maturing DCs changes their morphology and IL12 production. Michael S. von Bergwelt-Baildon et al. Blood 2006;108: ©2006 by American Society of Hematology

Induction of CD25 in monocyte-derived DCs. (A) Analysis of cell-surface expression of CD25 by the different DC populations using flow cytometry. Michael S. von Bergwelt-Baildon et al. Blood 2006;108: ©2006 by American Society of Hematology

Induction of CD25 in BDCA-1+ myeloid DCs. (A) Flow cytometry was performed after 18 hours of culture to assess cell-surface expression of CD1c, CD83, CD25 (x-axis), and HLA-DR (y-axis). Michael S. von Bergwelt-Baildon et al. Blood 2006;108: ©2006 by American Society of Hematology

Expression and function of IDO in monocyte-derived DCs and myeloid BDCA-1+ DCs. mRNA for RT-PCR and cell lysates for immunoblot analysis were obtained from monocytes, imDCs, or maDCs cultured in the presence or absence of PGE2. Michael S. von Bergwelt-Baildon et al. Blood 2006;108: ©2006 by American Society of Hematology

Monocyte-derived DCs retain the expression of functional IDO and CD25 after removal of PGE2 and maturation signals. Michael S. von Bergwelt-Baildon et al. Blood 2006;108: ©2006 by American Society of Hematology

Influence of DC supernatants on T-cell proliferation. Michael S. von Bergwelt-Baildon et al. Blood 2006;108: ©2006 by American Society of Hematology

Expression of CD25 and IDO in peritumoral dendritic cells. Michael S. von Bergwelt-Baildon et al. Blood 2006;108: ©2006 by American Society of Hematology