Pachymetric changes during corneal collagen cross-linking and effect of hydroxipropylmethylcellulose on corneal thickness Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul
Purpose To evaluate central corneal pachymetric changes during corneal collagen cross-linking (CXL) and effect of hydroxipropylmethylcellulose (HPMC) drops.
Hydroxipropylmethylcellulose Hypromellose Hydrophylic pH: 7,2-7,9 Osmolarity mOsm
Spoerl E,.Safety of UVA-riboflavin cross-linking of the cornea. Cornea 2007;26:385–9 Ophthalmology 2009; 116(12) (12
Methods Grup 1. (N=18). Epithelial abrasion (9mm) 0.1 % Riboflavin drops in dextrane every 3 minutes for 30 minutes. UVA 3mw/cm2 at 365nm for 30 min Grup 2. (N=21). Epithelial abrasion (9mm) 0.1 % Riboflavin drops in dextrane every 3 minutes and hydroxipropylmethylcellulose (HPMC) every 5 minutes for 30 minutes. UVA 3mw/cm2 at 365nm for 30 min Two groups were formed in patients with keratoconus undergoing cross- linking ;
Central corneal thicknesses were measured by ultrasound pachimetry – before epithelial abrasion, – after epithelial abrasion and – 30 minutes after beginning riboflavin installation
Before epithelial abrasionAfter epithelial abrasionP Grup ±54,9<0,001 Grup ,4±44,2 0,009 After epithelial abrasion30 minutes after riboflavin installation P Grup 1395±54,9360±44,4<0,001 Grup 2389,4±44,2374,4±38,10, Group 1 Group 2 After epithelial abrasion 30 minutes after riboflavin
Conclusion Decrease of corneal thickness continues with epithelial peeling. This decrease in corneal thickness is significantly reduced by continuing the procedure with the addition of HPMC. Rb+Dextran H2O Rb+Dextran H2O HPMC
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