H2OH2O

CaCO 3

C 2 H 5 OH

(C 650,000 H 4,400,000 O 1,800,000 N 100,000 Na 3 Cl 3 S 2 K 1 Ca 0.3 Mg 0.3 P 0.3 Fe 0.1 Zn 0.1 Cu 0.01 Si Co Se ….) n

Medical Use Trace Element

Human Carbonic Anhydrase II

Håkansson, K.; Carlsson, M.; Svensson, L. A.; Liljas, A. J. Mol. Biol. 1992, 227(4), CO 2 + H 2 O HCO 3 – + H + 3 × 10 8 dm 3 mol –1 s –1

The Main Challenges Understanding Biomimetic Chemistry New drugs

Selenium Intake UK / microg d -1 MAFF Food Surveillance Information Sheets 126 and 191

Biomimetic Chemistry 2H + + 2e - H 2 Hydrogenases CO 2 + H 2 O HCO H + Hydrases 6CO 2 + 6H 2 OC 6 H 12 O 6 + 6O 2 Photosystems

Liljas, A.; Xue, Y.; Vidgren, J.; Anders Svensson, L.; Jonsson, B. H.; Lindskog, S.; Proteins, 1993, 15, 80 Active Site Structure of HCA II Thr-200 His Complex with HCO 3 –

Complex and Active Site Zn(1) N(5) = 5.641(2) cf. Zn N(Thr199) = 5.851(4) Å

New Medicines O 2 + e - O 2 - superoxide 2O H + H 2 O 2 + O 2 Superoxide dismutase

IC 50 value = 3 x mol dm -3

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