Rh Lecture 7 Slides. Great new Krebs cycle (Citric Acid cycle) movie… fig 16-13

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Presentation transcript:

rh Lecture 7 Slides

Great new Krebs cycle (Citric Acid cycle) movie… fig

Krebs cycle features and functions… fig 16-13

CH 3 -C O O-O- O acetate acetyl group S-CoA AcCoA acetyl coenzyme A or acetyl-CoA CH 3 -C O it’s all about acetate… rh

fig16-1 all roads lead to acetyl-CoA…

fig16-1 electrons from acetyl groups

fig16-1 energy from electrons

fig16-3 This is HS-CoA, or CoA-SH, CoA, or coenzyme A

fig16-3 This is HS-CoA, or CoA-SH, CoA, or coenzyme A CoA-SH, or HS-CoA, or CoA

fig16-2 where the acetyl groups come from pyruvate dehydrogenase: PDH

fig Thiamine pyrophosphate (TPP): an activated carbon

fig TPP as a carbanion nucleophile in pyruvate metabolism

fig16-4 The “business end” of PDH Lipoic acid cofactor of PDH E 2

fig16-5 The PDH complex approx. 4.5 x 10 6 MW

fig16-5 The PDH complex

fig16-6 (old) The PDH catalytic cycle oxidation of pyruvate

Several reactions, one basic location fig16-6

Please read and LEARN “The Name Game”

fig16-7 The: Krebs cycle citric acid cycle TCA cycle

fig 16-8 Citrate synthase and its substrates…

pg 622 Getting fresh carbons into the act why it’s called the citric acid cycle

pg 622 making citrate asymmetric remember this for later…

fig16-10 an iron-sulfer cluster in aconitase

pg 624 (less fancy picture) electrons! NADH is the main carrier of Krebs cycle-derived electrons

pg 625 more electrons! note CoA-SH has re-entered the picture

pg 626 direct production of a high energy phosphate but not ATP… instead it’s GTP

pg 626 direct production of a high energy phosphate but not ATP… instead it’s GTP

pg 628 electrons to FAD instead of NAD +

rh The business end of FAD or FMN isoalloxazine ring

pg 628 electrons to FAD instead of NAD +

pg 628 a sensible inhibitor of succinate dehydrogenase INHIBITOR

old pg 612 Hydration of fumarate

pg 628 Hydration of fumarate

pg 628 high specificity exemplified by substrates and products of fumarase substrate product not a substrate

pg 628 high specificity exemplified by substrates and products of fumarase not a product substrate product

pg 628 the final electron removal

Krebs cycle features and functions… fig 16-13