Calcium score as a predictor of coronary artery disease severity in patients with acute coronary syndromes Coordinator Author Prof.Dr.Benedek Theodora Charikleia Tsolakidou University of Medicine and Pharmacy Târgu-Mureş Clinic of Cardiology Head of the Clinic - Prof. Dr. Benedek Imre, FESC

CORE patients, with coronary stenosis > 50% Sensitivity - 85% Specificity - 90% ACC/AHA guidelines, JACC, june 2010 ACCURACY patients, with coronary stenosis > 50% –Sensitivity - 95% –Specificity - 82% ROTTERDAM pacients, with coronary stenosis > 50% –Specificity - 99% –Specificity - 64% Cardio CT - accuracy for calculation of coronary artery calcium score

CORE patients, with coronary stenosis > 50% Sensitivity - 85% Specificity - 90% ACC/AHA guidelines, JACC, june 2010 ACCURACY patients, with coronary stenosis > 50% –Sensitivity - 95% –Specificity - 82% ROTTERDAM pacients, with coronary stenosis > 50% –Specificity - 99% –Specificity - 64% However, all these studies focused on features describing mainly the global coronary tree, while the association between calcium score and the severity of coronary lesions in acute coronary syndrome (ACS) has not been described yet.

AIM OF THE STUDY Correlation between the accumulation of calcium within the vessel wall of a coronary artery and the severity of coronary artery stenoses in patients who developed an acute coronary event.

Material and methods 29 patients Group 1 Ca score < patients Group 2 Ca score patients Group 3 Ca score > patients  CT: 1.calculation of coronary calcium scoring 1.complex plaque analysis Group 1 Group 2 Group 3

Mean calcium score(p<0.0001) gr / gr / gr / Results

Mean age gr.1 60 years gr.2 65 years gr.3 64 years.

Ejection Fraction Ejection fraction ( p=0.03) Gr.1 54,33% Gr.2 53% Gr.3 48,09%

3 vessel disease Gr.1 16,7% Gr.2 3,3% Gr.3 27,3%

One single artery disease Gr.1 83,3% Gr.2 58,3% Gr.3 9,1% (p=0.02)

Location of the culprit artery Left anterior descending Gr.1 66,7% Gr.2 66,7% Gr.3 72,7%

C alcium score is significantly associated with the severity of coronary artery disease and can be used as a useful prediction tool to evaluate the prognostic significance of coronary lesions in a non-invasive way. Conclusions