Moein Farshchian Ph.D Candidate of Cell and Molecular Biology.

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Presentation transcript:

Moein Farshchian Ph.D Candidate of Cell and Molecular Biology

* GENOMICS: A “Discipline” Less than 25 Years Old Victor A. McKusick

2. Comparative Genomics: Study of Conservation and Divergence of Genomes of Different Organisms 3. Functional Genomics: Development and Application of Global Approaches to Assess Gene Function

* Comparative Genomics Olson et al., (2002)

* Naive Way of Extracting Genes

Same genome  Different tissues Different physiology Different proteome Different expression pattern Anise swallowtail, Papilio zelicaon

Figure 7-44 Molecular Biology of the Cell (© Garland Science 2008)

* Cancer

Figure 7-77b Molecular Biology of the Cell (© Garland Science 2008)

* Clonal Hetrogeny in Tumor

Metastasis

- very low The incidence of cancer in non-human primates is very low. -All examined human cancer genes (n=333) are present in chimpanzee, contain intact open reading frames and show a high degree of conservation between both species (99.38%) -. Puente et al., (2006)

* Induced pluripotent Stem Cell (iPS Cells)

* Nature Review Cancer, April 2007

* Thanks