SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated High Grade Unresectable Malignant Peripheral Nerve Sheath Tumors Brigitte Widemann, NCI, POB

Trial Schema Eight chemotherapy courses total MPNST NF1 Sporadic IE x2IA x2 Response Evaluation Local Control Chemotherapy IE x2 PET 3D MRI Surgery XRT MRI PET 3D MRI

Patient Characteristics Two patients enrolled: –Pt. 1: 24 y/o male with NF1 and metastatic MPNST Toxicity: Tolerated chemotherapy well Response evaluation post cy 4: Stable (WHO), 37%  3D Complicated post surgery course, removed from protocol –Pt. 2: 21 y/o male with sporadic metastatic MPNST Pt. presented with leukemoid reaction, and widespread metastases Toxicity: Tolerated cy 1 of IA chemotherapy well (stable WHO) Removed from protocol after cy. 1 for palliative radiation for pain control and due to delayed platelet recovery as a result of bone marrow involvement.

SARC006 Protocol Status –Protocol (amendment #3) open for enrollment: National Cancer Institute, Pennsylvania Oncology –NF1 Sites: Close to approval: Children’s Memorial Chicago, Children’s Hospital and Clinics of Minnesota, Children’s Hospital of Philadelphia In review/consideration: Cincinnati Children’s Hospital, Children’s Hospital of Pittsburgh, St. Louis Children’s Hospital, University of Alabama at Birmingham, Children’s National Medical Center

SARC006 Protocol Status –SARC Sites: Close to approval: University of Michigan, Texas Children’s Hospital, Dana Farber Cancer Institute In review/consideration: University of Minnesota, MD Anderson, Mayo Clinic, Arkansas Children’s, Vanderbilt University, Emory University, Cleveland Clinic, Carolinas, Cedars Sinai, Lee Moffitt Cancer Center, Fox Chase Cancer Center, City of Hope, University of Utah, Stanford Comprehensive Cancer Center, Huntsman Cancer Center Not participating: Washington Cancer Institute, MSKCC, Johns Hopkins, Seattle Cancer Care, UCLA, University of Florida, Sarcoma Oncology Center, Oregon Health and Science University

SARC006 Approval Process Contract with SARC Institutional protocol review US Army IRB review: –I nformed consent form, assent (ages years) form, and information page (ages 7-12 years old), site specific protocol appendices –CV for all investigators –Facility safety plan –PI assurance plan –GCP training for PI US Army will perform pre-review of documents prior to local IRB submission All communication with US Army IRB through SARC