S The European Up-Front Risk Assessment Tool (EUFRAT) The European Up-Front Risk Assessment Tool (EUFRAT) (EUFRAT)

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Presentation transcript:

s The European Up-Front Risk Assessment Tool (EUFRAT) The European Up-Front Risk Assessment Tool (EUFRAT) (EUFRAT)

Presentation overview 1.Dynamics in blood transfusion chain 2.Risk model scheme 3.Outputs of the risk model 4.Modules in the risk assessment tool: –Tool functionality: Specification questions Risk calculator Options panel –User manual

Blood transfusion chain General population Donors Infected Plasma / components Processing products Final blood products Recipient Probability of infection Contamination probability & amount of infectious material Risk reduction Risk of infection Donor selection / screening Product risk

Risk Model Scheme Entities Modulating factors (input) Infected

Outputs of the risk model

Module: Tool functionality Specification questions Risk calculator Options panel: Additional settings/functions/documentation

Specification questions Specify the risk to be estimated and the data the users have available. 1.Do you want to estimate the risk of transfusion transmission from a donor who has visited an outbreak-affected region? 2.Is the number of infected donors available? 2.1. Are the infected donors identified by testing the donation? 2.2. Is the test performance (sensitivity & specificity) available? 3. Is information on various donation types and frequencies available? 4.Are there questions in the donor health questionnaire that potentially screen out the infected donors before donation? 5.Is the donated blood screened for the infection using a diagnostic test? 6.Is pathogen removal/inactivation or blood processing implemented to minimize the risk of contamination? 6.1. Is detail of infectivity level available?

Specification questions (continued) Entities Questions

Risk calculator Interface options: Disease selection Expand/collapse of five entities Constant/random variables Variable info and chart Editable fields

Risk calculator (continued) Disease selection: Select one from the eighteen emerging infections provided in dropdown menu OR select “Not specified” for calculating other diseases.

Risk calculator (continued) Expand/collapse: To show/hide the details of five entities Collapsed Expanded

Risk calculator (continued) Input/output variables: Constant: point estimate Random: estimate distributed in a range Validation text: inputs are valid for calculation Constant Random Validation text

Risk calculator (continued) Variable info and chart Info: help text of the variable. Chart: provided when the input/output is in range InfoChart

Risk calculator (continued) Adjustable inputs Add or delete Re-name Add/ delete

Options panel: Additional settings/functions/documentation Simulation: Generate number of samples With or without replacement (Automatic) calculation Generate samples (Automatic) calculation

Options panel (continued) Tool additional functions: Save inputs and outputs Load them for reuse, and Print results Additional functions

Options panel (continued) Documentation: Worked examples of emerging infections outbreaks with their risk estimates calculated using EUFRAT Presentation slides: summary of all tool functionalities.

User manual Contents: Introduction Step-by-step guidance List of definitions Infection data Risk model flowchart Modelling assumptions Formulas for calculation List of symbols Reference list