Center for the Environmental Implications of Nanotechology Program Solicitation NSF Preliminary Proposal Due: December 10, 2007 National Science Foundation Directorate for Biological Sciences Directorate for Education and Human Resources Directorate for Engineering Directorate for Geosciences Directorate for Mathematical & Physical Sciences Directorate for Social, Behavioral & Economic Sciences Alan J. Tessier, Lead Program Officer BIO/Division of Environmental Biology Environmental Protection Agency Nora Savage, Lead Program Officer EPA/Office of Research & Development National Center for Environmental Research

Center for the Environmental Implications of Nanotechology Preliminary Proposal Due:December 10, page project description Anticipated Funding Amount:$5 M/year for 5 years ($4M/yr NSF, $1M/yr EPA) Possibility of one 5-year renewal No cost share required Full proposal deadline: March 17, 2008 (invitation only)

CEIN Goals and Structure: “A National Center that will conduct fundamental research and education on the short- and long-term impact of nanotechnology on the environment and living systems at all scales.” “A multidisciplinary research approach involving the biological, chemical, physical, computational, mathematical, social and behavioral sciences will be needed to understand the fundamental processes and related risks associated with the interaction of naturally derived and engineered nanomaterials in the environment and living systems.” “The CEIN will address the implications of nanotechnology on environmental health and safety through fundamental research on the interactions of nanomaterials with the living world at all scales.”

CEIN Research and Education Focus: 1.Understanding the bioaccumulation of nanomaterials and their effects on living systems including their routes of environmental exposure, deposition, transformation, bio-persistence, clearance, and translocation, as well as mechanisms for their adsorption, distribution, metabolism, and excretion by organisms. 2.Understand the interactions of nanomaterials with cellular constitutents, metabolic networks and living tissues including interactions at the molecular, cellular, organ, and systemic levels, and effects on organisms ontogeny and multi-generational life histories. 3.Determining the biological impacts of nanomaterials dispersed in the environment including the ecological and evolutionary effects of nanomaterials on aquatic and terrestrial ecosystems such as: species interactions, factors that contribute to bioaccumulation and biomagnification of nanomaterials in food webs, distribution of nanomaterials and their byproducts within ecosystems, biotic processes that influence the persistence and chemical transformations of nanomaterials in the environment, and the mode and duration of effects on ecosystems.

Transforming Nanotechnology into a Tool to Solve Real-World Problems CBEN’s mission is to discover and develop nanomaterials that enable new medical and environmental technologies. The mission is accomplished by the following: Fundamental examination of the ‘wet/dry’ interface between nanomaterials, complex aqueous systems, and ultimately our environment (Theme 1). Engineering research that focuses on multifunctional nanoparticles that solve problems in environmental and biological engineering (Themes 2, 3). Educational programs that develop teachers, students, and citizens who are well informed and enthusiastic about nanotechnology. Innovative knowledge transfer that recognize the importance of communicating nanotechnology research to the media, policymakers, and the general public. Center for Biological and Environmental Nanotechnology Rice University

Center for Biological and Environmental Nanotechnology Rice University Theme 1: Nanoscience at the Wet/Dry Interface Nanomanufacturing: Materials Design and Production Forming, Characterizing and Optimizing Bionanoconjugates Developing SWNTs as Biological Materials Theme 2: Nanoparticles that Detect and Treat Disease Immunotargeted NIR Contrast Agents for Cancer Imaging Functional Imaging of Gene Expression NIR-absorbing Particles for Cancer Therapy Protease-activated Imaging Agents for Therapeutics Engineering Self-Organized Nano-Biomechanical Resonators Nanoparticle-cell: Structure-function Relationships for Cytotoxicity Theme 3: Effective, High-Performance Water Purification Systems Arsenic Removal using Nanoscale Magnetite Metal Nanocatalysts for Reducing Organics in Water Disinfection and Biofouling Control The Environmental Chemistry of Nanoscale Carbons Fate and Transport of Engineered Nanoparticles Environmental Toxicology, Biological Interactions and Bioavailability of Fullerenes Health, Environmental, and other Societal Impacts Assessing Public Trust and Perceptions of Risk The Ethics and Politics of Nanotechnology Research Activities listed on website

Nano/Bio Interface Center The University of Pennsylvania Biomolecular Optoelectronic Function Molecular Motions Single Molecular Probes Ethics of Nanotechnology Research Areas listed on website

Meeting Objectives: Develop a preliminary OU vision and research foci Identify currently available resources at OU and in Oklahoma - faculty and staff - equipment and facilities - governmental and industrial partners Identify resources necessary to obtain in order to be competitive Organize a working committee - identify potential members not present List potential candidates for PI / Center Director