U05-23088. 19 yo African female student (here since 2001) Medical exam for Immigration notable for protein-uria and Hematuria. Serum Creatinine 81umol/L.

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Presentation transcript:

U

19 yo African female student (here since 2001) Medical exam for Immigration notable for protein-uria and Hematuria. Serum Creatinine 81umol/L (88 Aug 5) No h/o UTI's or Pyelo. Headaches....Advil over 5 months Intermittent swellings lower Extremity Nonsmoker social Etoh Induced Aborton. Single partner (Sero -ve) 24 hour urine 5.6gms Negative Sero( ANA,C3,C,Hepatitis). Normal U/s Left lower pole Bx

IF IgG- Negative IgA- Moderate to strong mesangial staining IgM- Mild mesangial staining C3- Mild to moderate mesangial staining C1q- Negative Kappa- Mild mesangial staining Lambda- Mild to moderate mesangial staining Fibrin- Mild mesangial staining Albumin- Negative

IgA

IgM

C3

Kappa

Lambda

Fibrin

Diagnosis: Renal Biopsy: IgA Nephropathy with proliferative and necrotizing lesions including crescent formation