TRANSPLANTATION CHAPTER 8 ANZDATA Registry Annual Report 2013

Figure 8.1 Number of Kidney Transplant Operations Total (Living Donors) Year Australia New Zealand 1st2nd3rd4th5thTotal 1st2nd3rd4thTotal (0) (0) (3) (1) (5) (0) (2) (1) (0) (2) (0) (0) (1) (0) (1) (1) (2) (1) (7) (0) (6) (3) (7) (2) (10) (1) (16) (4) (17) (11) (34) (16) (36) (18) (35) (10) (53) (8) (48) (11) (48) (16) (36) (6) (32) (13) (40) (20) (46) (8) (48) (12) (59) (23) (78) (13) (70) (17) (66) (20) (103) (20) (94) (24) (115) (26) (147) (31) (161) (31) (169) (42) (181) (31) (213) (43) (230) (48) (218) (44) (244) (48) (246) (46) (273) (49) (271) (58) (354) (69) (327) (67) (296) (60) (255) (57) (238) (54)

ANZDATA Registry Annual Report 2013 Figure 8.2

ANZDATA Registry Annual Report 2013 Figure 8.3

ANZDATA Registry Annual Report 2013 Figure 8.4a

ANZDATA Registry Annual Report 2013 Figure 8.4b

ANZDATA Registry Annual Report 2013 Figure 8.5

ANZDATA Registry Annual Report 2013 Figure 8.6

ANZDATA Registry Annual Report 2013 Figure 8.7 * Pre-emptive transplant patients included

ANZDATA Registry Annual Report 2013 Figure 8.8 * Pre-emptive transplant patients included

ANZDATA Registry Annual Report 2013 Figure 8.9 Graft Number and Age of Patients Transplanted 2012 Donor Source Graft No. Age Groups Total Australia Deceased Living Donor Total New Zealand Deceased Living Donor Total

ANZDATA Registry Annual Report 2013 Figure 8.10

ANZDATA Registry Annual Report 2013 Figure 8.11

ANZDATA Registry Annual Report 2013 Figure 8.12 Australia Transplantation Rate - Age Group years Year Caucasian Aboriginal and Torres St. Islanders All Patients TxDialysedRate TxDialysedRate TxDialysedRate % % % % % % % % % % % % % % % % % % % % % % % % % % % % % %

ANZDATA Registry Annual Report 2013 Figure 8.13 New Zealand Transplantation Rate - Age Group years Year CaucasianMaoriPacific PeopleAll Patients TxDialysedRateTx Dialyse d RateTx Dialyse d RateTx Dialyse d Rate % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % % %

ANZDATA Registry Annual Report 2013 Figure 8.14 New Transplanted Patients Related to Ethnicity Race Australia 813 (100.0%)773 (100.0%)846 (100.0%)825 (100.0%)845 (100.0%) Caucasian 675 (83.0%)651 (84.2%)706 (83.5%)657 (79.6%)669 (79.2%) Aboriginal/Torres St. Islanders 31 (3.8%)24 (3.1%)28 (3.3%)28 (3.4%)20 (2.4%) Asian 83 (10.2%)75 (9.7%)83 (9.8%)97 (11.8%)88 (10.4%) Other 24 (3.0%)23 (3.0%)29 (3.4%)43 (5.2%)68 (8.0%) New Zealand 122 (100.0%)121 (100.0%)110 (100.0%)118 (100.0%)108 (100.0%) Caucasian93 (76.2%)91 (75.2%)71 (64.5%)77 (65.3%)74 (68.5%) Asian7 (5.7%)5 (4.1%)8 (7.3%)11 (9.3%)11 (10.2%) Maori12 (9.8%)19 (15.7%)20 (18.2%)20 (16.9%)15 (13.9%) Pacific10 (8.2%)6 (5.0%)9 (8.2%)9 (7.6%)7 (6.5%) Other--2 (1.8%)1 (0.8%)1 (0.9%)

ANZDATA Registry Annual Report 2013 Figure 8.15 Transplants in each Region Number of Operations (per Million Population per year) State Queensland 136 (32)140 (32)137 (31)155 (35)159 (35) New South Wales / ACT * 243 (33)238 (32)265 (35)232 (31)247 (32) Victoria / Tasmania * 246 (42)233 (39)285 (48)278 (46)268 (44) South Australia / NT * 110 (60)83 (45)82 (44)74 (40)88 (47) Western Australia 78 (36)79 (35)77 (34)86 (37)83 (34) Australia 813 (38)773 (35)846 (38)825 (37)845 (37) * For calculation of population related totals, the populations of these States were summed

ANZDATA Registry Annual Report 2013 Figure 8.16

ANZDATA Registry Annual Report 2013 Figure 8.17 NSW population excludes residents of the Southern Area Health Service ACT population includes residents of the Southern Area Health Service Medical services in the ACT service the Southern Area Region

ANZDATA Registry Annual Report 2013 Figure 8.18 Summary of Kidney Transplantation Australia PerformedFunctioning* Deceased Donor First Second Third Fourth 4814 Fifth 62 Total Living Donor First Second Third 5944 Fourth 107 Fifth 10 Total Total * Lost to follow up not included

ANZDATA Registry Annual Report 2013 Figure 8.18 Summary of Kidney Transplantation Australia Graft No.PerformedFunctioning* Deceased Donor First Second Third Fourth 4814 Fifth 62 Total Living Donor First Second Third 5944 Fourth 108 Fifth 10 Total Unknown First 015 Second 02 Total * Lost to follow up not included

ANZDATA Registry Annual Report 2013 Figure 8.19 Summary of Kidney Transplantation New Zealand PerformedFunctioning* Deceased Donor First Second Third 7618 Fourth 70 Total Living Donor First Second 8248 Third 64 Total UnknownFirst 02 Total * Lost to follow up not included

ANZDATA Registry Annual Report 2013 Figure 8.20 Functioning Transplants Transplanting Region, Australia and New Zealand (Number Per Million Population) YearQLD NSW/ACT * VIC/Tas *SA/NT *WA AustraliaNZ (326)1976 (282)1593 (295)726 (419)551 (282)6089 (306)1164 (289) (330)2077 (295)1671 (306)773 (444)585 (295)6395 (318)1218 (298) (333)2148 (303)1756 (317)783 (445)640 (317)6656 (326)1243 (301) (336)2232 (312)1870 (333)825 (464)684 (332)6987 (338)1256 (300) (341)2286 (316)1961 (344)870 (484)709 (335)7251 (345)1300 (307) (352)2394 (327)2095 (362)912 (502)748 (343)7654 (358)1350 (316) (361)2497 (336)2252 (382)935 (508)787 (350)8047 (370)1404 (325) (373)2648 (353)2416 (404)975 (524)818 (356)8506 (386)1440 (330) (384)2740 (362)2573 (426)988 (528)860 (366)8878 (398)1483 (337) (400)2866 (374)2718 (444)1029 (547)897 (372)9320 (413)1524 (344) * For calculation of population related totals, the population of these States were combined Patients lost to follow up are not included

ANZDATA Registry Annual Report 2013 Figure 8.21

ANZDATA Registry Annual Report 2013 Figure 8.22

ANZDATA Registry Annual Report 2013 Figure 8.23

ANZDATA Registry Annual Report 2013 Figure 8.24

ANZDATA Registry Annual Report 2013 Figure 8.25 Age of All Functioning Transplant Patients Resident Country at Transplant 31-Dec-2012 Donor Source Graft No. Age Groups Total Australia Deceased Donor Total Living Donor Total New Zealand Deceased Donor Total Living Donor Total

ANZDATA Registry Annual Report 2013 Figure 8.26a

ANZDATA Registry Annual Report 2013 Figure 8.16b

ANZDATA Registry Annual Report 2013 Figure 8.27a

ANZDATA Registry Annual Report 2013 Figure 8.27b

ANZDATA Registry Annual Report 2013 Figure 8.28 Functioning Transplant Patients - Resident Country at Transplant Related to Ethnicity and Age Group 31-Dec-2012 GenderRacial Origin Prevalent Age Groups Total Australia Female Caucasian Aboriginal/TSI Asian Other Total Male Caucasian Aboriginal/TSI Asian Other Total New Zealand Female Caucasian Asian Maori Pacific Other Total Male Caucasian Asian Maori Pacific Other Total

ANZDATA Registry Annual Report 2013 Figure 8.29

ANZDATA Registry Annual Report 2013 Figure 8.30

ANZDATA Registry Annual Report 2013 Figure 8.31 Graft Loss Rate Australia Death with Function 2.2%2.1%2.3%2.0%2.1% 1.7%2.0%2.3%1.6% Loss of Graft Function 2.6%3.1%2.7%2.4%2.5%2.9%2.7%2.3% 2.4% All Losses 4.9%5.2%5.0%4.4%4.6%5.0%4.4%4.3%4.7%4.1% New Zealand Death with Function 2.2% 2.3%2.6%3.2%1.8%2.3%2.2%2.7%1.7% Loss of Graft Function 2.5%1.8%3.4%3.5%2.9%2.0%2.4%2.1%2.0%2.4% All Losses 4.7%4.0%5.6%6.0%6.1%3.9%4.7%4.4%4.7%4.1%

ANZDATA Registry Annual Report 2013 Figure 8.32 Year of Graft Loss Due to Death or Failure LossCause of Failure Total Australia Failed Death with Function Rejection - Acute Chronic Allograft (CAN) Rejection - Hyperacute Vascular Technical Problems Glomerulonephritis Non Compliance Other Total New Zealand Failed Death with Function Rejection - Acute Chronic Allograft (CAN) Rejection - Hyperacute Vascular Technical Problems Glomerulonephritis Non Compliance Other Total

ANZDATA Registry Annual Report 2013 Figure 8.33 Graft Losses Cause of Loss AustraliaNew Zealand Graft Function <1 year>= 1 yearAny Time<1 year>= 1 yearAny Time Death with functioning Graft Cardiac 19 (27%)178 (22%)197 (22%)5 (50%)44 (29%)49 (30%) Vascular 7 (10%)69 (8%)76 (9%)1 (10%)8 (5%)9 (6%) Infection 29 (41%)133 (16%)162 (18%)-23 (15%)23 (14%) Social 2 (3%)66 (8%)68 (8%)1 (10%)8 (5%)9 (6%) Malignancy 5 (7%)276 (34%)281 (32%)2 (20%)53 (35%)55 (34%) Miscellaneous 8 (11%)93 (11%)101 (11%)1 (10%)15 (10%)16 (10%) Total 70 (100%)815 (100%)885 (100%)10 (100%)151 (100%)161 (100%) Graft Failure Rejection - Acute 30 (21%)25 (2%)55 (5%)-6 (4%) Rejection - Chronic Allograft (CAN) 10 (7%)795 (79%)805 (70%)1 (7%)105 (71%)106 (65%) Rejection - Hyperacute 3 (2%)-3 (<1%)--- Vascular 44 (31%)14 (1%)58 (5%)5 (33%)4 (3%)9 (6%) Technical Problems 12 (9%)5 (<1%)17 (1%)--- Glomerulonephritis 8 (6%)63 (6%)71 (6%)--- Non Compliance 1 (1%)38 (4%)39 (3%)1 (7%)9 (6%)10 (6%) Other 33 (23%)67 (7%)100 (9%)5 (33%)9 (6%)14 (9%) Total 141 (100%)1007 (100%)1148 (100%)15 (100%)148 (100%)163 (100%)

ANZDATA Registry Annual Report 2013 Figure 8.34 Australia Immunosuppressive Therapy - Primary Deceased Donor Graft YearAzaCyATacrolMMFMPASirol Everolimu s Pred Number of Deceased Donor Grafts Initial treatment (3%)131 (41%)172 (54%)299 (94%)4 (1%)17 (5%)-308 (97%) (51%)139 (45%)260 (85%)24 (8%)3 (1%)19 (6%)296 (97%) (1%)138 (48%)140 (49%)244 (85%)36 (13%)-5 (2%)285 (99%) (1%)137 (35%)240 (61%)364 (93%)22 (6%)--389 (99%) (1%)62 (16%)310 (82%)356 (95%)13 (3%)-3 (1%)375 (100%) (14%)409 (86%)426 (89%)37 (8%)1 (<1%)3 (1%)477 (100%) (<1%)54 (11%)446 (87%)300 (59%) 204 (40%) (99%) (<1%)22 (4%)409 (77%)343 (64%)93 (17%)6 (1%)-440 (83%)533 Treatment at 12 months (8%)83 (29%)172 (59%)229 (79%)21 (7%)29 (10%)3 (1%)262 (90%) (4%)94 (34%)145 (52%)216 (78%)27 (10%)21 (8%)20 (7%)259 (93%) (5%)86 (32%)149 (56%)189 (71%)51 (19%)12 (5%)14 (5%)252 (95%) (5%)84 (23%)251 (70%)288 (80%)37 (10%)12 (3%)9 (2%)345 (96%) (5%)40 (11%)283 (80%)282 (80%)39 (11%)18 (5%)9 (3%)341 (96%) (5%)52 (11%)370 (81%)323 (71%)82 (18%)16 (4%)11 (2%)440 (97%) (5%)26 (5%)391 (81%)223 (46%) 179 (37%) 8 (2%)13 (3%)432 (89%)485 Treatment at 24 months (8%)76 (27%)156 (55%)220 (78%)23 (8%)45 (16%)5 (2%)238 (84%) (6%)81 (30%)144 (53%)207 (76%)31 (11%)23 (8%)25 (9%)248 (92%) (5%)79 (31%)152 (59%)181 (70%)54 (21%)14 (5%)13 (5%)243 (94%) (6%)80 (23%)238 (68%)275 (79%)39 (11%)12 (3%)9 (3%)324 (93%) (7%)39 (11%)273 (79%)254 (74%)53 (15%)20 (6%)11 (3%)328 (95%) (6%)45 (10%)328 (76%)293 (68%)71 (16%)20 (5%)14 (3%)391 (91%)432 Aza = Azathioprine CyA = Cyclosporine Tacrol = Tacrolimus MMF = Mycophenolate Mofetil MPA = Mycophenolic Acid (Enteric Coated) Sirol = Sirolimus Pred = Prednisolone

ANZDATA Registry Annual Report 2013 Aza = Azathioprine CyA = Cyclosporine Tacrol = Tacrolimus MMF = Mycophenolate Mofetil MPA = Mycophenolic Acid (Enteric Coated) Sirol = Sirolimus Pred = Prednisolone Figure 8.35 New Zealand Immunosuppressive Therapy - Primary Deceased Donor Graft YearAzaCyATacrolMMFMPASirol Everolimu s Pred Number of Deceased Donor Grafts Initial treatment (76%)8 (19%)41 (98%) (68%)11 (30%)34 (92%)--3 (8%)37 (100%) (74%)15 (26%)57 (98%)--1 (2%)58 (100%) (67%)15 (33%)42 (93%)3 (7%)--45 (100%) (78%)10 (20%)49 (98%) (71%)13 (29%)45 (100%) (71%)17 (29%)58 (100%) (66%)13 (26%)46 (92%) Treatment at 12 months (5%)21 (55%)16 (42%)33 (87%)1 (3%)2 (5%)1 (3%)35 (92%) (53%)15 (45%)29 (88%)--3 (9%)32 (97%) (6%)31 (60%)20 (38%)43 (83%)-2 (4%)1 (2%)48 (92%) (5%)21 (48%)23 (52%)39 (89%)1 (2%)--41 (93%) (50%)23 (48%)48 (100%)-1 (2%)-45 (94%) (5%)16 (37%)27 (63%)41 (95%)---42 (98%) (4%)22 (41%)27 (50%)45 (83%)---47 (87%)54 Treatment at 24 months (6%)18 (50%)17 (47%)30 (83%)1 (3%)2 (6%)1 (3%)29 (81%) (50%) 28 (88%)--2 (6%)30 (94%) (6%)29 (58%)20 (40%)41 (82%)-2 (4%)1 (2%)45 (90%) (5%)20 (48%)22 (52%)37 (88%)-1 (2%)-40 (95%) (46%)24 (52%)45 (98%)-1 (2%)-42 (91%) (5%)15 (36%)25 (60%)37 (88%)--- 42

ANZDATA Registry Annual Report 2013 Figure 8.36 Antibody Use for Induction Immunosuppression Australia and New Zealand Number of Kidney Transplant Recipients Receiving Each Agent by Year (% Total New Transplants) Australia Muromonab-CD3-1 (0.1%)--13 (1.5%) Intravenous immunoglobulin25 (3.1%)28 (3.6%)39 (4.6%)42 (5.1%)26 (3.1%) Anti-CD25740 (91.0%)715 (92.5%)800 (94.6%)765 (92.7%)569 (67.3%) Rituximab21 (2.6%)17 (2.2%)9 (1.1%)10 (1.2%)7 (0.8%) T cell depleting polyclonal Ab22 (2.7%)40 (5.2%)52 (6.1%)33 (4.0%)20 (2.4%) Total new transplants (0.6%) New Zealand Intravenous immunoglobulin----1 (0.9%) Anti-CD2574 (60.7%)63 (52.1%)65 (59.1%)114 (96.6%)99 (91.7%) Rituximab1 (0.8%)2 (1.7%)1 (0.9%)3 (2.5%)4 (3.7%) T cell depleting polyclonal Ab--1 (0.9%)1 (0.8%)- Total new transplants

ANZDATA Registry Annual Report 2013 Figure 8.37 Antibody Use as Treatment for Acute Rejection Australia and New Zealand Number of Kidney Transplant Recipients Receiving Each Agent by Year (% Total New Transplants) Australia Muromonab-CD310 (1.2%)12 (1.6%)2 (0.2%)-- Intravenous immunoglobulin89 (10.9%)105 (13.6%)92 (10.9%)105 (12.7%)41 (4.9%) Anti-CD251 (0.1%) --- Rituximab24 (3.0%)26 (3.4%)15 (1.8%)11 (1.3%)6 (0.7%) T cell depleting polyclonal Ab19 (2.3%)27 (3.5%)41 (4.8%)42 (5.1%)20 (2.4%) Total new transplants Total transplants at risk New Zealand Muromonab-CD310 (8.2%)8 (6.6%)4 (3.6%)-- Intravenous immunoglobulin2 (1.6%)7 (5.8%)4 (3.6%)3 (2.5%)3 (2.8%) Anti-CD251 (0.8%)-- - Rituximab-3 (2.5%)--1 (0.9%) T cell depleting polyclonal Ab3 (2.5%)2 (1.7%)12 (10.9%)11 (9.3%)4 (3.7%) Total new transplants Total transplants at risk

ANZDATA Registry Annual Report 2013 Figure 8.38 Australia and New Zealand Rejection Rates at Six Months Post Transplant Donor Source Living Donor First graft 27.7%21.6%19.6% 21.1%17.0%16.8%17.8%17.5%11.0% Second and subsequent grafts 33.3%34.8%18.5%33.3%34.3%30.0%24.3%12.9%18.5%10.3% Deceased Donor First graft 26.8%22.8%18.6%16.3%17.7%22.0%21.1%18.7%20.0%13.7% Second and subsequent grafts 25.0%27.5%31.7%36.4%32.8%32.9%36.5%27.3%17.7%19.2%

ANZDATA Registry Annual Report 2013 Figure 8.39 Primary Deceased Donor - Australia Recipient and Graft Survival % [95% Confidence Interval] Year of Transplant Survival 1 month6 months1 year5 years Recipient Survival (n=609)99 (97, 99)96 (94, 97)95 (93, 97)85 (82, 88) (n=601)99 (98, 100)96 (94, 97)95 (93, 97)88 (85, 90) (n=606)99 (97, 99)97 (95, 98)96 (94, 97)87 (84, 89) (n=559)99 (98, 100)97 (96, 98)96 (94, 97)87 (84, 90) (n=615)99 (98, 100)97 (96, 98)96 (94, 97)90 (88, 92) (n=636)99 (98, 100)97 (95, 98)96 (94, 97)88 (85, 90) (n=625)99 (98, 100)97 (96, 98)96 (94, 97)89 (86, 91) (n=678)99 (98, 100)98 (97, 99)97 (96, 98)91 (89, 93) (n=854)99 (98, 100)98 (97, 99)98 (96, 98) (n=1044)100 (99, 100)98 (97, 99)97 (96, 98)- Graft Survival (n=609)93 (91, 95)89 (86, 91)88 (85, 90)73 (69, 76) (n=601)95 (92, 96)90 (88, 92)89 (86, 91)78 (74, 81) (n=606)95 (93, 97)92 (90, 94)90 (88, 92)77 (74, 80) (n=559)96 (95, 98)93 (91, 95)92 (89, 94)80 (76, 83) (n=615)96 (94, 97)94 (92, 96)92 (90, 94)82 (79, 85) (n=636)94 (92, 96)92 (90, 94)91 (88, 93)80 (76, 83) (n=625)95 (93, 97)93 (91, 95)91 (89, 93)79 (76, 82) (n=678)96 (94, 97)94 (92, 95)92 (90, 94)81 (78, 84) (n=854)98 (97, 99)96 (95, 97)95 (93, 96) (n=1044)98 (97, 99)96 (94, 97)95 (93, 96)-

ANZDATA Registry Annual Report 2013 Figure 8.40a

ANZDATA Registry Annual Report 2013 Figure 8.40b

ANZDATA Registry Annual Report 2013 Figure 8.43 Recipient and Graft Survival of Primary Grafts Deceased Donors - Australia and New Zealand Recipient Survival Graft Survival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs (n=1149)77.0%57.4%44.4%34.2%25.1% 58.2%41.9%30.3%22.8%14.6% (n=1463)81.0%63.6%49.4%35.5%26.2% 51.7%36.0%25.6%17.7%12.6% (n=1595)91.4%75.1%59.4%45.9%34.7% 63.3%45.4%32.1%23.0%16.2% (n=1916)92.1%80.3%64.5%51.2%39.6% 80.8%65.8%47.2%32.9%21.4% (n=1906)93.4%83.9%67.7%53.2%40.9% 85.0%70.9%50.7%34.7%23.7% (n=1779)94.7%86.1%72.4%57.1%- 88.6%76.2%58.6%41.7% (n=1850)96.0%89.1%77.0% %80.8%64.0% (n=1911)96.7%89.5% %80.5% (n=1675)97.5% %----

ANZDATA Registry Annual Report 2013 Figure 8.44

ANZDATA Registry Annual Report 2013 Figure 8.45 Second and Subsequent Deceased Donor - Australia Recipient and Graft Survival % [95% Confidence Interval] Year of Transplant Survival 1 month6 months1 year5 years Recipient Survival (n=121)98 (94, 100)98 (93, 99)94 (88, 97)86 (78, 91) (n=107)99 (94, 100)97 (92, 99) 86 (78, 91) (n=109)10097 (92, 99)95 (89, 98)86 (78, 91) (n=77)99 (91, 100)96 (88, 99)95 (87, 98)86 (76, 92) (n=87)99 (92, 100)94 (87, 98)92 (84, 96)87 (78, 93) (n=95)99 (93, 100)98 (92, 99)95 (88, 98)85 (76, 91) (n=120)10099 (94, 100)97 (91, 99)88 (81, 93) (n=125)99 (94, 100)98 (93, 99)96 (91, 98)85 (76, 90) (n=142)99 (95, 100)97 (93, 99)95 (90, 98) (n=133)10099 (94, 100) - Graft Survival (n=121)87 (79, 92)85 (77, 90)83 (76, 89)70 (61, 78) (n=107)83 (75, 89)78 (68, 84)77 (67, 84)61 (51, 69) (n=109)93 (86, 96)89 (81, 94)84 (76, 90)73 (64, 81) (n=77)92 (83, 96)88 (79, 94)87 (77, 93)68 (56, 77) (n=87)92 (84, 96)85 (76, 91)82 (72, 88)67 (56, 75) (n=95)94 (86, 97) 89 (81, 94)72 (61, 80) (n=120)97 (91, 99)93 (87, 97)89 (82, 94)71 (62, 78) (n=125)96 (91, 98)93 (87, 96)90 (84, 94)70 (61, 78) (n=142)94 (89, 97)93 (87, 96)91 (85, 95) (n=133)98 (94, 100)98 (93, 99)95 (89, 98)-

ANZDATA Registry Annual Report 2013 Figure 8.46a

ANZDATA Registry Annual Report 2013 Figure 8.46b

ANZDATA Registry Annual Report 2013 Figure 8.47 Recipient and Graft Survival of Second and Subsequent Grafts Deceased Donors Australia and New Zealand Recipient Survival Graft Survival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs (n=158)79.1%55.7%42.4%33.5%26.6% 58.9%37.3%27.2%21.5%14.6% (n=284)78.2%57.4%44.7%31.3%20.0% 44.0%28.2%20.4%15.0%8.1% (n=417)90.6%74.8%59.0%46.8%37.1% 48.9%36.0%25.6%20.3%14.2% (n=458)93.7%79.2%62.8%47.3%35.1% 70.1%51.7%34.4%23.2%13.9% (n=374)93.0%82.6%67.9%54.0%40.8% 78.3%64.2%44.1%31.2%21.0% (n=296)95.9%86.1%73.3%60.0%- 81.8%66.6%44.3%31.1% (n=268)93.7%86.2%74.8% %70.1%51.5% (n=343)96.2%87.9% %73.1% (n=217)96.3% %----

ANZDATA Registry Annual Report 2013 Figure 8.48

ANZDATA Registry Annual Report 2013 Figure 8.49 Australia Year of Transplant Primary Living Donor Grafts Recipient and Graft Survival % [95% Confidence Interval] 1 month6 months1 year5 years Recipient Survival (n=160)10099 (95, 100)98 (94, 99)94 (89, 97) (n=186)10098 (95, 99)97 (94, 99)95 (90, 97) (n=284)10099 (96, 99)98 (96, 99)96 (93, 98) (n=320)99 (98, 100)98 (96, 99) 94 (91, 96) (n=410)100 (98, 100)99 (97, 100)99 (97, 99)95 (92, 97) (n=419)100 (98, 100)99 (97, 100) 94 (92, 96) (n=463)100 (98, 100) 99 (98, 100)97 (95, 98) (n=557)100 (99, 100)99 (97, 99) 94 (92, 96) (n=564)100 (99, 100)99 (98, 100)98 (97, 99) (n=447) (98, 100) - Graft Survival (n=160)97 (93, 99)96 (91, 98)95 (90, 97)85 (78, 90) (n=186)93 (88, 96)91 (86, 94)90 (84, 93)84 (78, 89) (n=284)98 (96, 99)97 (94, 98)96 (94, 98)87 (82, 90) (n=320)97 (94, 98)95 (92, 97)94 (91, 96)86 (82, 90) (n=410)98 (96, 99)96 (94, 98)96 (93, 97)88 (85, 91) (n=419)99 (97, 100)98 (96, 99)97 (95, 98)88 (84, 91) (n=463)98 (97, 99)98 (96, 99)97 (95, 98)90 (87, 93) (n=557)98 (96, 99)97 (95, 98) 88 (85, 91) (n=564)99 (98, 100)98 (97, 99)97 (95, 98) (n=447)99 (97, 99)98 (96, 99) -

ANZDATA Registry Annual Report 2013 Figure 8.50 New Zealand Year of Transplant Primary Living Donor Grafts Recipient and Graft Survival % [95% Confidence Interval] 1 month6 months1 year5 years Recipient Survival (n=160)10099 (95, 100)98 (94, 99)94 (89, 97) (n=186)10098 (95, 99)97 (94, 99)95 (90, 97) (n=284)10099 (96, 99)98 (96, 99)96 (93, 98) (n=320)99 (98, 100)98 (96, 99) 94 (91, 96) (n=410)100 (98, 100)99 (97, 100)99 (97, 99)95 (92, 97) (n=419)100 (98, 100)99 (97, 100) 94 (92, 96) (n=463)100 (98, 100) 99 (98, 100)97 (95, 98) (n=557)100 (99, 100)99 (97, 99) 94 (92, 96) (n=564)100 (99, 100)99 (98, 100)98 (97, 99) (n=447) (98, 100) - Graft Survival (n=35)91 (76, 97)89 (72, 96) 74 (56, 86) (n=46)98 (86, 100) 76 (61, 86) (n=57)96 (87, 99) 95 (85, 98)72 (58, 82) (n=66)95 (87, 99)94 (85, 98) 82 (70, 89) (n=83)10099 (92, 100) 88 (79, 93) (n=88)97 (90, 99)95 (88, 98) 86 (77, 92) (n=88)99 (92, 100)97 (90, 99)95 (88, 98)91 (83, 95) (n=120)98 (94, 100)98 (92, 99)97 (91, 99)84 (76, 90) (n=118)99 (94, 100)97 (92, 99)97 (91, 99) (n=101)97 (91, 99) 95 (87, 98)-

ANZDATA Registry Annual Report 2013 Figure 8.51

ANZDATA Registry Annual Report 2013 Figure 8.52

ANZDATA Registry Annual Report 2013 Figure 8.53

ANZDATA Registry Annual Report 2013 Figure 8.54

ANZDATA Registry Annual Report 2013 Figure 8.55 Recipient and Graft Survival of Primary Grafts Living Donors - Australia and New Zealand Recipient Survival Graft Survival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs (n=21)90.5%81.0%61.9%52.4%42.9% 85.7%76.2%61.5%46.2%20.5% (n=107)90.7%78.5%71.0%61.7%52.2% 81.2%63.3%49.9%41.2%31.1% (n=241)96.3%85.4%74.9%64.8%55.4% 82.8%71.2%59.3%46.5%35.9% (n=230)95.2%87.8%79.9%71.1%62.9% 90.8%74.8%60.5%45.1%35.0% (n=431)97.2%89.2%84.0%74.5%68.5% 91.8%79.6%65.3%48.8%32.0% (n=766)98.6%94.7%86.6%76.8%- 94.5%84.0%68.8%52.1% (n=1193)98.5%94.3%86.6% %87.7%72.4% (n=1585)98.5%95.2% %89.1% (n=873)99.0% %----

ANZDATA Registry Annual Report 2013 Figure 8.56

ANZDATA Registry Annual Report 2013 Figure 8.57 Recipient and Graft Survival of Second and Subsequent Grafts Living Donors - Australia and New Zealand Recipient Survival GraftSurvival Time Period1 year5 yrs10 yrs15 yrs20 yrs 1 year5 yrs10 yrs15 yrs20 yrs (n=1)100.0% (n=11)100.0% 81.8%72.7%63.6% 72.7%45.5%36.4% 27.3% (n=42)97.6%81.0%78.6%71.4%51.9% 78.6%64.3%59.5%50.0%40.5% (n=31)96.8%83.9%71.0%64.5%47.5% 87.1%74.2%58.1%45.2%29.0% (n=38)100.0%94.7%73.3%67.9%51.3% 100.0%86.8%41.2%35.7%24.7% (n=74)98.6% 89.2%81.1%- 93.2%82.4%68.9%57.9% (n=107)98.1%95.3%85.7% %85.0%67.2% (n=175)98.3%93.2% %82.1% (n=87)98.7% %----

ANZDATA Registry Annual Report 2013 Figure 8.58