Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy.

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Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

CSB Fig 02:01 Cell signalling pathways CSB Fig 02:01 Cell signalling pathways Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge

Transducers Second Messengers II 1.Cyclic ADPribose ADP Ribosyl cyclase ADP Ribosyl cyclase 2.Inositol phosphate & other lipid signaling PLC – PIP2, DAG PLC – PIP2, DAG PI3K – PIP3 PI3K – PIP3 PLD – PA PLD – PA

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:22 cADPR metabolism CSB Fig 2:22 cADPR metabolism

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:26 NAADP structure CSB Fig 2:26 NAADP structure

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:23 cADPR/NAADP function CSB Fig 2:23 cADPR/NAADP function

Transducers Second Messengers II 1.Calcium signaling 1.Cyclic ADPribose 2.Inositol phosphate & other lipid signaling PLC – PIP2, DAG PLC – PIP2, DAG PI3K – PIP3 PI3K – PIP3 PLD – PA PLD – PA

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:30 Phosphoinositide signalling systems CSB Fig 2:30 Phosphoinositide signalling systems

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:27 Phosphoinositide metabolism CSB Fig 2:27 Phosphoinositide metabolism

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:28 PtdIns structure CSB Fig 2:28 PtdIns structure

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:29 PI 3-K family CSB Fig 2:29 PI 3-K family

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:31 Inositol phosphate metabolism CSB Fig 2:31 Inositol phosphate metabolism

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:32 InsP3 and DAG formation CSB Fig 2:32 InsP3 and DAG formation

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:33 InsP3 and DAG formation CSB Fig 2:33 InsP3 and DAG formation

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:34 InsP3/Ca2+ signalling functions CSB Fig 2:34 InsP3/Ca2+ signalling functions

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:35 InsP3/DAG recycling CSB Fig 2:35 InsP3/DAG recycling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:36 PLC structure and function CSB Fig 2:36 PLC structure and function

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:37 PKC structure and activation CSB Fig 2:37 PKC structure and activation

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:38 Localized inositol lipid signalling CSB Fig 2:38 Localized inositol lipid signalling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:39 PtdIns4,5P2 signalling CSB Fig 2:39 PtdIns4,5P2 signalling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:40 PtdIns4,5P2 regulation of K+ channels CSB Fig 2:40 PtdIns4,5P2 regulation of K+ channels

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:41 PtdIns4,5P2 regulation of TRP channels CSB Fig 2:41 PtdIns4,5P2 regulation of TRP channels

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:42 PtdIns 3-kinase signalling CSB Fig 2:42 PtdIns 3-kinase signalling

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:43 Insulin receptor CSB Fig 2:43 Insulin receptor

Cell Signalling Biology - Michael J. Berridge Cell Signalling Biology - Michael J. Berridge CSB Fig 2:44 PIKfyve activation CSB Fig 2:44 PIKfyve activation

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