DF – Deep-frozen FD – Freeze-dried Tissue/Bone Bank Types of Tissue/Bone AllograftNational Tissue Bank, USM No. (pieces) DF Knee slices0 DF Femur5 DF Femoral head75 DF Humerus0 DF Tibia4 DF Radius1 DF Ulna0 FD Cancellous37 FD Cortical0 FD Cortico-cancellous0 Patella4 Other tendon / fascia / cartilage1 Amniotic membranes379 TOTAL506 Table 7.1.1: Types Of Tissue/Bone Allografts Supplied by National Tissue Bank, USM in 2006

Tissue/Bone Bank National Tissue Bank, USM No. (pieces) MOH Hospital Selayang3 Hospital Seremban1 Hospital Sultanah Aminah, Johor Bahru11 Hospital Pantai Air Keroh, Melaka4 Hospital Pulau Pinang7 Hospital Ipoh9 Hospital Alor Setar6 Hospital Umum Sarawak10 Hospital Kuala Terengganu2 Hospital Kemaman10 Hospital Tengku Ampuan Afzan, Kuantan2 Hospital Raja Perempuan Zainab II, Kota Bharu1 Queen Elizabeth Hospital, Sabah12 TOTAL78 University HUKM3 HUSM29 TOTAL32 Private and other sectors Antal Rastu Sdn Bhd2 Kota Bharu Medical Centre2 Kota Medical Centre, Melaka1 Lam Wah Ee Penang3 Pantai Medical Centre, Air Keroh1 Stryker6 Sunway Medical Centre1 TOTAL16 Table 7.1.2: Hospitals/Other Sectors Using Bone Allografts in 2006

Tissue/Bone Bank National Tissue Bank, USM No. (pieces) MOH Hospital Kuala Lumpur13 Hospital Selayang1 Hospital Sultanah Aminah, Johor Bahru200 Hospital Melaka10 Hospital Alor Setar2 Hospital Teluk Intan1 Hospital Tengku Ampuan Afzan, Kuantan7 Hospital Queen Elizabeth4 TOTAL238 University HUSM8 UMMC4 HUKM2 TOTAL14 Private and other sectors Gleneagles Medical Centre, Penang8 Hospital Pakar Johor100 Sri Kota Medical Centre, Klang4 Pusat Rawatan Islam Al-Zahirah, Bangi Selangor10 Hospital Tawakal, Kuala Lumpur4 Putra Medical Centre1 TOTAL127 Table 7.1.3: Hospitals/Other Sectors Using Amniotic Membranes in 2006

Centre TOTAL No. Orthopaedics Department Orthopaedics Department, HUSM17210 Department of Orthopaedics Surgery, UMMC1001 Institute of Orthopaedic & Traumatology, HKL2002 Department of Orthopaedics, Hospital Ipoh0101 Department of Orthopaedics, Hospital Kota Bharu93012 Orthopaedic Department, Hospital Umum Sarawak1012 Orthopaedics Department, Hospital Sultanah Aminah, Johor Bahru0101 Wan Orthopaedic, Trauma & Sports Injury Centre (WOTSIC), Seremban Specialist Hospital0022 Orthopaedics Department, Hospital Island, Penang0101 Orthopaedics Department, Hospital Fatimah, Ipoh0303 Orthopaedics Department, Kota Bharu Medical Centre0022 Normah Medical Specialist Centre, Kuching0101 Spine Unit, HUSM0011 Ophthalmology Department Ophthalmology Dept, Hospital Tengku Ampuan Rahimah, Klang1102 Ophthalmology Dept, Hospital Tengku Ampuan Afzan, Kuantan1102 Ophthalmology Department, Hospital Teluk Intan0011 Ophthalmology Department, HKL0023 Ophthalmology Department, Hospital Alor Setar0011 Ophthalmology Department, Sri Kota Medical Centre, Klang0101 Ophthalmology Department, HUSM0011 Others Department Maxillofacial Surgery, HUSM1102 Timberland Medical Centre0101 Sri Kota Medical Centre, Klang0011 TOTAL Table 7.2.1: Distribution of Reporting Centre by Year

Gender TOTAL No.% % % % Male Female TOTAL Ethnic Group TOTAL No.% % % % Malay Chinese Indian Bumiputra Sabah Bumiputra Sarawak Others TOTAL Table 7.3.1: Distribution of Patients by Gender Table 7.3.2: Distribution of Patients by Ethnic Group

Age Group TOTAL No.% % % % ≥ Missing TOTAL Mean SD Median Min15700 Max6075 Table 7.3.3: Distribution of Patients by Age Group

Diagnosis TOTAL No.% % % % Congenital deformity Infection Trauma Degenerative disease Tumour-benign Tumour-malignant Burn Scald Sports injury Failed primary surgery Ophthalmological Others TOTAL Table 7.3.4: Distribution of Patients by Diagnosis Warranting Tissue Graft Transplantation

Name Tissue Bank TOTAL No.% % % % Tissue Bank, USM Bone Bank, UMMC Bone Bank, HKL Eucara Pharmaceutical Osteo Tech Inc Missing TOTAL Origin of Tissue Graft TOTAL No.% % % % Local Imported Missing TOTAL Table 7.4.1: Distribution of Patients According to Tissue Provider Table 7.4.2: Distribution of Patients by Origin of Tissue Graft

Tissue Graft TypeTissue Graft Types TOTAL No.% % % % Deep frozen tissues Femur Femoral Head Humerus Tibia Radius Freeze dried (Lyophilised) Amniotic membranes Not Available Missing TOTAL Table 7.4.3: Distribution of Patients by Tissue Graft Type

Type Graft Sterilisation TOTAL No.% % % % Gamma Irradiation Glycerol Sterile Freeze Dried Bone Missing TOTAL Mode of Transport Storage to recipient hospital TOTAL No.% % % % By Flight By Courier By Hand Dry Ice Box Sterile package Missing TOTAL Table 7.4.4: Distribution of Type of Sterilisation of the Graft Table 7.4.5: Distribution of Mode of Transport Storage to Recipient Hospital during Transportation

Temperature of storage during transportation ( o C) TOTAL No.% % % % Missing TOTAL Table 7.4.6: Distribution of Temperature of Storage during Transportation

Mode of storage in recipient hospital TOTAL No.% % % % Refrigerator Deep freezer-20 degree Celsius Deep freezer-40 degree Celsius Deep freezer-80 degree Celsius Glycerol Room temperature Others Not available Missing TOTAL Table 7.5.1: Distribution of Mode of Storage in Recipient Hospitals

Additional tissue usage (composite graft) TOTAL No.% % % % No Yes Not available Missing TOTAL Type of additional tissue used (composite graft) TOTAL No.% % % % Autografts Allografts Others Missing TOTAL Table 7.5.2: Distribution of Additional Tissue Usage (Composite Graft) Table 7.5.3: Distribution of Type of Additional Tissue Used (Composite Graft)

Presence of pre operative infection at implant site TOTAL No.% % % % No Yes Not Available Missing TOTAL Pre implant graft culture swab TOTAL No.% % % % No Yes Not Available Missing TOTAL Table 7.5.4: Distribution of Presence of Pre Operative Infection at Implant Site Table 7.5.5: Distribution of Pre Implant Graft Culture Swab

Type of infection of pre implant graft TOTAL No.% % % % Cytomegalovirus Proteus TOTAL Grafts soaked in antibiotics prior to transplantation TOTAL No.% % % % No Yes Not Available Missing TOTAL Table 7.5.6: Distribution of Type of Infection of Pre Implant Graft Table 7.5.7: Distribution of Grafts Soaked in Antibiotics Prior to Transplantation

Antibiotics used to soak the grafts in prior to transplantation TOTAL No.% % % % Ceftriazone Gentamycin Ceftriazone and Gentamycin Vancomycin, Postome iodine Povidone iodine, Ceftriazone Missing TOTAL Systemic antibiotics prior to transplantation TOTAL No.% % % % No Yes Not Available Missing TOTAL Table 7.5.8: Distribution of Antibiotics Used to Soak the Grafts in Prior to Transplantation Table 7.5.9: Distribution of Patients by Systemic Antibiotics Given Prior to Transplantation

Type of systemic antibiotics given to patient prior to transplantation TOTAL No.% % % % Cefeperazone Ceftriazone Cefuroxine Ciproflaxacin Chloramphenicol Metronidazole Ceftazidine Ceftriazone/Imipenam Ampicillin/Sulbactam Missing TOTAL Table : Distribution of Patients by Type of Systemic Antibiotics Given Prior to Transplantation