DR.A.Tahamoli Rudsari.  Rheumatoid arthritis (RA) is a chronic multisystem disease of unknown cause.  Although there are a variety of systemic manifestations,

Slides:



Advertisements
Similar presentations
RHEUMATOID ARTHRITIS RA Inson lou. Epidemiology Symptoms signs Labs Diagnosis Treatment.
Advertisements

doc.MUDr. Želmíra Macejová, PhD III. Internal clinic LF UPJŠ
RHEUMATOID ARTHRITIS MUHAMMAD ADEEL (BIOT 412) Human Diseases Presentation.
Tests for Rheumatoid Arthritis Chua, Kathleen. Laboratory Findings Rheumatoid factors Antibodies to Cyclic Citrullinated Peptide (Anti-CCP) CBC with differential.
NSAIDs 1 st line of therapy in the medical management of RA.
FeaturesGouty ArthritisRheumatoid Arthritis Nature Metabolic DiseaseAutoimmune Disease Process Inflammatory reaction to microcrystal of sodium urate Chronic.
Presented by: Cheryl Ann Peters. * A chronic, systemic and inflammatory autoimmune disease in which immune cells attack and destroy exocrine glands that.
RHEUMATOID ARTHRITIS VS OSTEOARTHRITIS Anusha Reddy FY1 General Surgery (UHCW) 25 th Nov 2013.
Dr. Zhao TCM help Rheumatoid Arthritis. What is Rheumatoid Arthritis (RA)? RA is an autoimmune disorder inflammation of the lining of the joints. The body.
1 IN THE NAME OF GOD. 2 Rheumatoid Arthritis A chronic multisystem disease Characteristic feature: Persistent inflammatory synovitis Peripheral joints.
Arthritis and Podiatric Medicine: Walking Hand-in-Hand Dr. Dennis R. Frisch 30 SE 7 th Street Boca Raton, FL
Immunology Stack Slackers Facts by Mike Ori. Disclaimer The information represents my understanding only so errors and omissions are probably rampant.
Diagnosing inflammatory arthritis
Value of inflammatory markers Useful for diagnosis of inflammatory vs non inflammatory conditions Remember NON-SPECIFIC, increased in infection, inflammation,
Joint Replacement Stephanie Arrington. Joint Replacement  Research suggests that more than a million people a year are getting a total joint replacement.
Tena Trbojević Mentor: A. Žmegač Horvat
Rheumatology: OSTEOARTHRITIS RHEUMATOID ARTHRITIS Dr. Meg-angela Christi Amores.
Disorders of the salivary glands
Dr Shoaib Raza.   Immune reactions against self antigens  Affects 1% to 2% of US population  Requirements for an autoimmune disorder:  Presence of.
Lecture 22 Autoimmunity.
Sjögren’s Syndrome Austen Bowling Kiara Bell. What is Sjögren's Syndrome? a chronic disorder in which the white blood cells attack the saliva and tear.
Harjot Sihota MD4 #1034. Introduction An autoimmune disease characterized by destruction of the lacrimal and salivary glands, resulting in the inability.
The Integumentary System. Functions Covering Regulation Manufacturing Stimulation Storage Screening Absorbtion.
Rheumatoid Arthritis Anila Malik GPVTS. Aims To cover the following: What is RA? Diagnostic criteria and clinical features Rheumatoid Factor Investigations.
Rheumatoid Arthritis(RA)
WELCOME TO UNIT 2 SEMINAR!. Rheumatoid arthritis (ra)
Recomendations for the medicamentous treatment of chronic inflammatory rheumatic disease pain Dušan Logar Dpt.of Rheumatology, University Clinical Centre,
RHEUMATOID ARTHRITIS By: Julie Le and Mary Le 5/2/12 4 th pd.
Orthopaedics Wa’el N. Qa’dan, MSc. Rheumatoid arthritis (RA): It is the commonest cause of chronic inflammatory joint disease. Most typical.
Overview of Arthritis Brought to you in collaboration by: 1. Arthritis Foundation Tennessee Chapter 2. Tennessee Department of Health 3. University of.
Dr. Mahboob Ur Rahman BSPT,PPDPT,EMBA Chief Physiotherapist HMC Peshawar/ Founder &Chairman Mahboob School of Physiotherapy Hayatabad.
Kara Kliethermes Jim Shinaberry December 6, 2012.
NRU 5200 Advanced Practice Presentation Rheumatoid Arthritis Erin Whitley, BSN, RN.
Rheumatoid Arthritis (RA) By: Leon Richardson Period
Rheumatoid Arthritis(RA) Dr. Gehan Mohamed. Learning objectives: At the end of this lecture the student should be able to : understand definition,genetic.
Adult Medical-Surgical Nursing Musculo-skeletal Module: Rheumatoid Arthritis.
Rheumatoid Arthritis Sean Stives. What is it? Chronic disease affecting mainly synovial joints (usually in the hands and feet) Causes pain and stiffening.
Physiological Diseases of the human Skeleton. Inflammatory Disorders of joints Joint pain and discomfort can be caused by many factors Bursitis Arthritis.
Rheumatoid Arthritis.
Rheumatoid Arthritis Dr Chandini Rao Consultant Rheumatologist.
Major manifestations of rheumatologic diseases 1.
AUTOIMMUNITY-I,II, III PRACTICAL 4. l Case No 1 l A 25-year-old woman has had increasing malaise, a skin rash of her face exacerbated by sunlight exposure,
R HEUMATOID F ACTOR ( RF ). Rheumatoid arthritis is a chronic inflammatory disorder that affects all joints either in hands or feet and other areas of.
RHEUMATOID ARTHRITIS (RA)
Rheumatoid Arthritis Christine Aranyi and Rebecca Boon State university of new york institute of technology Pathophysiolog y Rheumatoid Arthritis (RA)
N124IN Spring  Pathophysiology Deterioration of articular cartilage and bone ends of joint  Smaller joint space  Bone spurs occur  Inflammation.
Pathology of thyroid 2 Dr: Salah Ahmed. Thyroiditis - inflammation of the thyroid gland, includes a group of disorders characterized by some form of thyroid.
RHEUMATOID ARTHRITIS (RA). Introduction RA is a chronic, systemic inflammatory disorder of unknown etiology characterized by the manner in which it involved.
1 IN THE NAME OF GOD. 2 Rheumatoid Arthritis A chronic inflammatory disease A systemic disease Characteristic feature: Persistent inflammatory synovitis.
AUTOIMMUNITY- III. Autoimmunity Part-III l At the end of the session the student should be able to: l a. Describe the pathogenesis of important autoimmune.
Rheumatology Normal Anatomy andPhysiology. Synovial joints: Normal Anatomy 1. Bone: 2. Cartilage: 3. Synovium:
Rheumatoid arthritis (RA).  Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally.
Introduction to collagen-vascular diseases. Definition: Rheumatologic (or Rheumatic) Disease: diseases characterized by pain and inflammation in joints.
Systemic Lupus Erythematosus. SLE or Lupus - is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts.
4. Rheumatologic conditions
Identifying Early Inflammatory Arthritis
Rheumatic Diseases “Arthritis”
Rheumatoid Arthritis Hayley Evans, CMCBI, King’s College London, UK
Tests for Rheumatoid Arthritis
Rheumatoid Arthritis and Your Organs
Sjogren’s Syndrome and Xerostomia – An Overview
Autoimmune diseases Ali Al Khader, M.D. Faculty of Medicine
Managing Rheumatoid arthritis
Enteropathic Arthropathy
Rheumatoid Arthritis Objectives:
AUTOIMMUNE DISEASES.
Arthritis Katie Gerou.
Rheumatoid Arthiritis
Overview of Arthritis Brought to you in collaboration by:
Presentation transcript:

DR.A.Tahamoli Rudsari

 Rheumatoid arthritis (RA) is a chronic multisystem disease of unknown cause.  Although there are a variety of systemic manifestations, the characteristic feature of established RA is chronic inflammatory symmetric polyarthritis.

 The prevalence of RA is 0.5 – 1% of the adult population.  Women are affected approximately three times more often than men.  25 – 50 y

 RA is found at approximately times the expected rate in first-degree relatives of RA patients.  10 – 25 %  The class II major histocompatibility complex allele are known to be major genetic risk factors for RA.  HLA-DRB1  PTPN22

 Smoking  EBV

 RA affects the synovial tissue and underlying cartilage and bone.  The pathologic hallmarks of RA are synovial inflammation and proliferation, focal bone erosions, and thinning of articular cartilage.

Pathogenesis

 Articular manifestation  Exteraarticular manifestation

Chronic inflammatory symmetric polyarthritis

extraarticular features

 RF  Anti CCP  CBC, ESR, CRP, BUN, Cr, AST, AIT, …  Synovial fluid analysis

 Early in the disease, radiographic evaluations of the affected joints are usually not helpful in establishing a diagnosis.  Plain radiography

 NSAIDs  Glucocorticoids  DMARDs HCQ MTX SSZ LEF

 Biological DMARDs Anti – TNF agents Rituximab Anakinra Abatacept Tocilizumab

 Sjögren's syndrome is a chronic, slowly progressive autoimmune disease characterized by lymphocytic infiltration of the exocrine glands resulting in xerostomia and dry eyes.

 Approximately one-third of patients present with systemic manifestations.  Primary Sjögren's syndrome  Secondary Sjögren's syndrome

 The prevalence of primary Sjögren's syndrome is approximately 0.5–1.0%, while 30% of patients with autoimmune rheumatic diseases suffer from secondary Sjögren's syndrome.

 RA  SLE  SSC  MCTD  PBC  Vasculitis  CAH

 Middle-aged women are primarily affected.  Female/Male : 9/1

 Exocrine gland features  Extraglandular disease features  8–10 years may elapse from the initial symptoms to full-blown development of the disease.

 The principal oral symptom of Sjögren's syndrome is dryness (xerostomia).  Physical examination shows a dry, erythematous, sticky oral mucosa.  Enlargement of the parotid or other major salivary glands occurs in two-thirds of patients with primary Sjögren's syndrome but is uncommon in those with the secondary syndrome.`

 Patients usually complain of a sandy or gritty feeling under the eyelids.  Other symptoms include burning, accumulation of thick strands at the inner canthi, decreased tearing, redness, itching, eye fatigue, and increased photosensitivity.  keratoconjunctivitis sicca

 Extraglandular (systemic) manifestations are seen in one-third of patients with Sjögren's syndrome, while they are very rare in patients with Sjögren's syndrome associated with rheumatoid arthritis.

 Anti Ro/SS-A  Anti La/SS-B