Introduction to Neuropsychology. Introduction Lecture Series: 1. (a) Introduction; (b) Memory 2. Visual Perception 3. Motor Behaviour 4. Emotion 5. Executive.

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Presentation transcript:

Introduction to Neuropsychology

Introduction Lecture Series: 1. (a) Introduction; (b) Memory 2. Visual Perception 3. Motor Behaviour 4. Emotion 5. Executive Function Lecture Series: 1. (a) Introduction; (b) Memory 2. Visual Perception 3. Motor Behaviour 4. Emotion 5. Executive Function

Introduction...lectures 6. Language 7. Lateralisation 8. Current Issues/Debates 9. Revision/Discussion 10. Exam...lectures 6. Language 7. Lateralisation 8. Current Issues/Debates 9. Revision/Discussion 10. Exam

Presentations (30%) 15min presentation (groups [3]) on a particular area of neuropsychology (e.g. memory) a) An understanding of the behavioural deficits that result from the circumscribed brain damage b) An appreciation for the inferences that can be drawn from the presented case(s) c) An awareness of the advantages and limitations of the “lesion” approach in advancing our understanding of brain-behaviour relationships, within the context of the presented case(s). Presentations (30%) 15min presentation (groups [3]) on a particular area of neuropsychology (e.g. memory) a) An understanding of the behavioural deficits that result from the circumscribed brain damage b) An appreciation for the inferences that can be drawn from the presented case(s) c) An awareness of the advantages and limitations of the “lesion” approach in advancing our understanding of brain-behaviour relationships, within the context of the presented case(s). Introduction

Exam (70%) 1hr written exam answering 2 questions (related to areas covered in the lectures) a) An understanding of the behavioural deficits that result from the circumscribed brain damage b) An appreciation for the inferences that can be drawn from the presented case(s) c) An awareness of the advantages and limitations of the “lesion” approach in advancing our understanding of brain-behaviour relationships, within the context of the presented case(s). Exam (70%) 1hr written exam answering 2 questions (related to areas covered in the lectures) a) An understanding of the behavioural deficits that result from the circumscribed brain damage b) An appreciation for the inferences that can be drawn from the presented case(s) c) An awareness of the advantages and limitations of the “lesion” approach in advancing our understanding of brain-behaviour relationships, within the context of the presented case(s). Introduction

Basic Anatomy

Memory Patient H.M. (The Hippocampus)

Hippocampus

Patient H.M. (Scoville & Milner, 1957)

Patient H.M. (Scoville & Milner, 1957) (Corkin et al., 1997)

Patient H.M. (Corkin et al., 1997)

Patient H.M. (Scoville & Milner, 1957; Milner, Corkin & Teuber, 1968)  Bilateral medial temporal-lobe excisions (5cm posterior) in 1953 (27yrs old)  At 19 months x Retrograde amnesia (3yrs) x Anterograde amnesia x Age*, date, address* x Verbal stimuli x Non-verbal stimuli IQ = Good vocabulary/articulation Visual perception Abstract thinking* Reasoning ability No change in personality Normal digit span

Patient H.M. IQ vs. Memory (Corkin, 1984)

Wechsler Memory Scale (WMS-IV)

Patient H.M. Perception (Milner, Corkin & Teuber, 1968)

Patient H.M. Executive function (Milner, Corkin & Teuber, 1968)

Patient H.M. Short-term Memory (STM) (Wickelgren, 1968)

Patient H.M. Long-term Memory (LTM) (Marlsen-Wilson & Teuber, 1975)

Patient H.M. Non-verbal LTM (Milner, 1965)

Patient K.F. Double Dissociation (STM) (Shallice & Warrington, 1969)

Hippocampus: Lateralisation (Milner, 1965)

Patient H.M. Non-verbal LTM

Patient H.M. (Milner, 1965)

Patient H.M. Procedural LTM (Milner, 1962; [Corkin, 1968])

Patient N.A. Perception (Tueber, Milner & Vaughan, 1968)

Patient N.A. Non-verbal LTM (Tueber, Milner & Vaughan, 1968)

Patient N.A. Non-verbal LTM (Tueber, Milner & Vaughan, 1968)

Patient N.A. Non-verbal LTM (Tueber, Milner & Vaughan, 1968)

Patient N.A. Verbal LTM (Tueber, Milner & Vaughan, 1968)

Patient N.A. Procedural LTM (Cohen & Squire, 1980)

Patient R.B. Hippocampus: CA1 (Zola-Morgan, Squire & Amaral, 1980)

Patient R.B. Hippocampus: CA1 (Zola-Morgan, Squire & Amaral, 1980)

Patient R.B. Hippocampus: CA1 (Zola-Morgan, Squire & Amaral, 1980)

Animal Models Neuroanatomy (Mishkin, 1978)

Animal Models Consolidation (Zola-Morgan & Squire, 1990)

Animal Models Consolidation (Kim & Fanselow, 1992)

Animal Models STM vs. LTM (Alvarez, Zola-Morgan & Squire, 1994)

Architecture of Memory (Squire & Knowlton, 1995; Vargha-Khadem, 1997)

The End

Example Exam Questions 1. How have neuropsychological investigations revealed multiple memory systems? 2. How has H.M. informed the neuropsychology of memory 1. How have neuropsychological investigations revealed multiple memory systems? 2. How has H.M. informed the neuropsychology of memory