Cartilage and Bone VIBS 443/602

OBJECTIVES GENERAL ORGANIZATION MECHANISM OF GROWTH CHARACTERISTICS OF CELLS

CELLS OF CT FIBROBLASTS MESENCHYMAL CELLS and RBC ADIPOSE CELLS MACROPHAGE PLASMA CELLS MAST CELLS and WBC CHONDROBLASTS CHONDROCYTES OSTEOBLASTS OSTEOCYTES OSTEOCLASTS

TYPES OF CARTILAGE FIBROCARTILAGE HYALINE CARTILAGE ELASTIC CARTILAGE

primary spongiosa of the Fetal finger 220

Fetal elbow 194

Fetal elbow 194

Tibia, fetal

Trachea, monkey 133

EM 11: cartilage 1.Chondrocyte 2.Fibroblast 3.Appositional growth region 4.Type I collagen 5.Type II collagen Appositional growth of cartilage

EM 13: cartilage interstitial growth of chondrocytes 1.2 daughter chondrocytes resulting from interstitial growth 2.Rough endoplasmic reticulum interstitial growth of cartilage

HYALINE CARTILAGE EPIPHYSEAL PLATE, RESPONSIBLE FOR LONGITUDINAL GROWTH OF LONG BONES

cartilage growth in endochondral bone formation of the Fetal finger 220

OSTEOCLAST OSTEOBLAST

OSTEOCLAST OSTEOBLAST

Elastic cartilage in pina of ear #19762 Elastic cartilage Connective tissue epithelium Connective tissue epithelium Elastic cartilage

FIBROCARTILAGE INTERMEDIATE BETWEEN DENSE REGULAR CONNECTIVE TISSUE AND HYALINE CARTILAGE NO PERICHONDRIUM

Fibrocartilage of Fetal elbow 194 Fibrocartilage

Fibrocartilage of Fetal elbow 194 Fibrocartilage

Fibrocartilage of Fetal elbow 194 Fibrocartilage

Fetal finger – fibroblasts in tendon 220 Fibrocartilage Tendon

endochondral bone formation

CELLS OF BONE OSTEOBLASTS - SECRETE OSTEOID - BONE –EXPAND BONE BY APPOSITIONAL GROWTH OSTEOCYTE = OSTEOBLAST TRAPPED IN MATRIX OF BONE

EM 12: osteoblast adjacent to osteoid; bone; RER and Golgi 1.Rough endoplasmic reticulum 2.Golgi 3.Osteoid 4.Nucleus of osteoblast APPOSITIONAL GROWTH

CELLS OF BONE

FUNCTIONS OF BONE CALCIUM REGULATION Parathroid hormone (BONE RESORPTION) Calcitonin (PREVENTS RESORPTION) These HORMONES are INVOLVED IN TIGHT REGULATION as 1/4 OF FREE CA ++ IN BLOOD IS EXCHANGED EACH MINUTE. HEMOPOIESIS

COMPACT BONE HAVERSIAN SYSTEMS - LAMELLAE OF BONE AROUND HAVERSIAN CANAL LINKED BY VOLKMANN’S CANAL

COMPACT BONE REMODELING Over time

COMPACT BONE REMODELING

Slide 121: compact bone (unstained ground bone) 1.Blood vessel 2.Haversian canal 3.Interstitial system 4.Lacuna

Bone (unstained) 425

Bone (unstained) 425

Bone, rabbit femur 121

Bone, rabbit femur 121

Bone, rabbit femur 121

Tibia, fetal

Osteoblasts in the Fetal jaw 195

Osteoclasts, osteoblasts, and osteocytes in Fetal jaw 195 osteocytes osteoclasts osteoblasts

Rib

How many Osteoclastsof Fetal finger can you spot? Osteoclasts

ENDOCHONDRAL (SPONGY/ CANCELLOUS) BONE FORMATION CARTILAGE MODEL CENTERS OF OSSIFICATION PRIMARY CENTER OF OSSIFICATION DIAPHYSIS SECOND CENTER OF OSSIFICATION CENTER OF EACH EPIPHYSIS

cartilage growth in endochondral bone formation of the Fetal finger

Articular surfaces of hyaline cartilage of the Fetal elbow 194

HISTOGENESIS OF BONE INTRAMEMBRANOUS OSSIFICATION FLAT BONES OF SKULL

SKELETAL CONNECTIVE TISSUE

32583

Polychromatic normoblast